DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg4 and nlgn3a

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	XP_005157256.1	Gene:	nlgn3a / 562702	ZFINID:	ZDB-GENE-071219-1	Length:	878	Species:	Danio rerio

Alignment Length:	1000	Identity:	310/1000 - (31%)
Similarity:	440/1000 - (44%)	Gaps:	271/1000 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCP 108
            |.|:||:|.|..:||.| ..|..|:.:|||||||||..:.||.|...|:.|.||:.:..::||||
Zfish    71 VNTQYGKLRGARVPLHS-EILGPVDQYLGVPYATPPVGEKRFLPPEPPSSWSGIKNATHFAPVCP 134

  Fly   109 QRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPV------------------ 155
            |   ||.|....: .||......|..:...:::|:|||||||::.|.
Zfish   135 Q---NIHNAVPEI-MMPIWFTFNLDIVATSIQDQNEDCLYLNIYVPTEDVKRISKECTRKPNKKI 195

  Fly   156 --NAGANEKK---------------------LPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVV 197
              ..|.:.||                     .||:|:|||.|:...:||..|||||||||.|:|:
Zfish   196 CRKGGTHSKKQGEDLSDNDGDEDEDIRDTGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVI 260

  Fly   198 TLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACI 262
            |||:|:|:||||:...    .|...||||:||:.||.||.:||..||||.|.:|:.|.|.||:|:
Zfish   261 TLNFRVGVLGFLSTGD----QAAKGNYGLLDQIQALRWISENIGYFGGDSNRITVFGSGIGASCV 321

  Fly   263 NYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLR 327
            : |:|......|||||||:.||||.||||:...||.:...||::|.|.:.|.::     :|||||
Zfish   322 S-LLTLSHHSEGLFHRAIIQSGSALSSWAVNYQPVKYTRLLAEKVGCNVLDTLD-----MVDCLR 380

  Fly   328 DVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGG 392
            .....:|...|||...:..:|||.:||.||..     |.:.||.:
Zfish   381 KKSARELVEQDIQPARYHVAFGPVIDGDVIPD-----DPEILMEQ-------------------- 420

  Fly   393 QGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRF--SAHDIQNGFEGE 455
                               |.|       :|    ||::.||..||.: ||  :..|.::|..|.
Zfish   421 -------------------GEF-------LN----YDIMLGVNQGEGL-RFVENVVDSEDGVSGN 454

  Fly   456 RRDKIIRTYVRNAYNY-----HLNEIFYTIVNEYTDW-DRTSQHPINTRDTAVAALSDAQFVAPI 514
            ..|..:..:|.:.|.|     .|.|   ||...|||| ||  .:|...|.|.||..:|.|:|.|.
Zfish   455 DFDFSVSDFVDSLYGYPEGKDTLRE---TIKFMYTDWADR--DNPETRRKTLVALFTDHQWVEPS 514

  Fly   515 VRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVH 579
            |...|:.|           ..|||                  .|||.|.:..:....|......|
Zfish   515 VVTADLHA-----------RYGSP------------------TYFYAFYHHCQSLMKPAWSDAAH 550

  Fly   580 GEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNR 644
            |:::||:||.|::.....||.|::|::..||..||.:|||||:||:||:...||:.. :..:.||
Zfish   551 GDEVPYVFGIPMIGPTDLFPCNFSKNDIMLSAVVMTYWTNFAKTGDPNKPVPQDTKF-IHTKANR 614

  Fly   645 FRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDM 709
            |..:.|..|:|..|.||.||:|||:::|:||.:::.|..|:|.|:..        |::|.
Zfish   615 FEEVAWSKYNPQDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNL--------HDMFH----- 666

  Fly   710 DLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEP 774
                                  .:|:::....|......|..|:.   ||.|:           |
Zfish   667 ----------------------YTSTTTKVPPLETTQNSLSTKRP---NGKAW-----------P 695

  Fly   775 NNMYTTCIPIGGNYSSSGGVF--------APTTLANASSDTLASGFEAAGYAAYSTALSVTIAIG 831
            .|  |...|:...|:|..|..        .|..:.|...              |||.||||||:|
Zfish   696 FN--TKRPPMSPAYNSESGKEQWNGEEEPGPLVVENPRD--------------YSTELSVTIAVG 744

  Fly   832 CSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQRSLHQQVPYPPEPI------KHAHYHMGHSQ 890
            .|||.||||.||.:||::||.|      |:|:.|       |.||...      :||     ..:
Zfish   745 ASLLFLNVLAFAALYYRKDKRR------QEQHPQ-------PSPPRATTTNDVNRHA-----PEE 791

  Fly   891 SSANVIVDVESHQDQAGQAAMLLQAA-----AAAAAAAANDVKPPPPHICSNT---------GMQ 941
            ...::.|:...|:..||.....|:.|     |.....:.:|:    |.:..||         ||.
Zfish   792 EIMSLQVNQTHHECDAGPTGDPLRLASLPDYALTLRRSPDDI----PLMTPNTITMIPNSLVGMP 852

  Fly   942 QQQQVGGGSGGALNNGGIEGSKVTT 966
            ........:.| .|:.|:..|..||
Zfish   853 NLHPYNTFTAG-FNSTGLPHSHSTT 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	237/685 (35%)
nlgn3a	XP_005157256.1	COesterase	69..651	CDD:306613	237/685 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23133
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1641
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.970