Protein Alignment Nlg4 and nlgn4xa

DIOPT Version :9

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_021330915.1
• Gene: nlgn4xa / 561122
• ZFINID: ZDB-GENE-100309-2
• Length: 844
• Species: Danio rerio
• Alignment Length: 1112
• Identity: 315/1112 - (28%)
• Similarity: 459/1112 - (41%)
• Gaps: 339/1112 - (30%)

  Fly     7 LLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFL 71
            |..|||.....:..:|:....|..          |.||.|.||:|.||..||.: ..|..||.:|
Zfish    18 LATLRLFTWIVLAAAWLAITWAQQ----------HPIVTTNYGKLRGLKTPLPN-EILGPVEQYL 71

  Fly    72 GVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLL 136
            |:|||.|||.:.||.|...|..|.|||.:.:::|||||.|   ::.....:.:|......|..::
Zfish    72 GIPYALPPTGERRFQPPEPPMSWPGIRNATQFAPVCPQFL---EDRFLLNDMLPVWFTANLDTVV 133

  Fly   137 PFLENQSEDCLYLNVFSPV-------------NAGANEKKL-------PVIVFIHGESFEWSSGN 181
            .::::|||||||||::.|.             |.|...|.:       ||:|:|||.|:...:||
Zfish   134 TYVQDQSEDCLYLNIYVPTEDVGANKGDDFTNNEGGENKDIHDENGLRPVMVYIHGGSYMEGTGN 198

  Fly   182 PYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGD 246
            ..|||:|||||.|:|||||||||:||||:...    .|...||||:||:.||.||::|||.|.||
Zfish   199 MIDGSILASYGNVIVVTLNYRLGVLGFLSTGD----QAAKGNYGLLDQIQALRWIKENIQAFKGD 259

  Fly   247 PNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTI 311
            |..||:.|.|.||:|:: |:|.......||.:||:.||:|.||||:...|..:...||::|.|.:
Zfish   260 PKRVTIFGSGAGASCVS-LLTLSHYSEDLFQKAIIQSGTALSSWAVNYQPAKYTRILAEKVGCNM 323

  Fly   312 PDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDD---LMARN 373
            .|.|:     :|:||::...::|....|....:..:|||.:||.||.        ||   ||.:
Zfish   324 LDSID-----LVECLQNKNYKELIEQYITQAKYHIAFGPVIDGDVIP--------DDPQILMEQ- 374

  Fly   374 SRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGE 438
                                                  |.|       :|    ||::.||..||
Zfish   375 --------------------------------------GEF-------LN----YDIMLGVNQGE 390

  Fly   439 SIWRF--SAHDIQNGFEGERRDKIIRTYVRNAYNY-----HLNEIFYTIVNEYTDWDRTSQHPIN 496
            . ::|  ...|.::|......|..:..:|.:.|.|     .|.|   ||...|||| ...::|..
Zfish   391 G-FKFVDGIVDSEDGVSANDFDFAVSDFVDHLYGYPEGKDTLRE---TIKFMYTDW-ADKENPET 450

  Fly   497 TRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYV 561
            .|.|.||..:|.|:|||.|...|:.|           ..|||                  .|||.
Zfish   451 RRKTLVALFTDHQWVAPAVATADLHA-----------QYGSP------------------TYFYA 486

  Fly   562 FDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNP 626
            |.:..:....|....:.||:::||:||.|::.....|..|::|::..||..||.:|||||:||:|
Zfish   487 FYHHCQSEMKPSWSDSAHGDEVPYVFGIPMLGPTDLFNCNFSKNDVMLSAVVMTYWTNFAKTGDP 551

  Fly   627 NEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRA 691
            |:...||:.. :..:.|||..:.|..|:|..|.||.||:|||:::|:||.:::.||.|:|.||
Zfish   552 NQPVPQDTKF-IHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLH-- 613

  Fly   692 GMEDVIARHNLFRNHDDMDLYEG------PVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLM 750
                         |.:::..|..      |....||..:...|.:..|
Zfish   614 -------------NINELFQYVSTTTKIPPQDTTPFPYTKRLGKTWPS----------------- 648

  Fly   751 MKKGRGLNGSAYLNGILGVTTVEP-----NNMYTTCIPIGGNYSSSGGVFAPTTLANASSDTLAS 810
                               ||..|     |...||....|.:.|....|...|.
Zfish   649 -------------------TTRHPGVPPANTKQTTDQRKGNDLSDDSAVVIETK----------- 683

  Fly   811 GFEAAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQRSLHQQVPYP 875
                   ..|||.||||||:|.|||.||:|.||.:||::||.|               |:.....
Zfish   684 -------RDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRR---------------HESNRRG 726

  Fly   876 PEPIKHAHYHMGHSQSSANVIVDVESHQDQAGQAAMLLQAAAAAAAAAANDVKPPPPHICSNTGM 940
            |.|.:::        :.|||:                         |.|||:    .|:.|:..|
Zfish   727 PSPQRNS--------APANVV-------------------------ANANDI----AHLQSDELM 754

  Fly   941 QQQQQVGGGSGGALNNGGIEGSKVTTDNLGNVTYSTSSKQQQQHQQQQQQQQREHMQIKGMT--- 1002
            ..|.:                                 :||.:|:...:....:......:|
Zfish   755 SLQMK---------------------------------QQQMEHEHHHECDSLQAHDTLRLTCPA 786

  Fly  1003 -GTQTFGRSGSGSGGGAGGGAGSASGGASVVVSGSSVSYNP----GMMTLPK---SGGLHHAATL 1059
             .|.|..||...                ..:::.|:::..|    ||.||..   .||..::..|
Zfish   787 DYTLTLRRSPDD----------------IPLMTPSTITMIPNTLAGMQTLHNFNTFGGSQNSTNL 835

  Fly  1060 NYARNTT 1066
            .:..:||
Zfish   836 PHGHSTT 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	229/667 (34%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:306613	229/668 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1641
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.830