DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg4 and nlgn2a

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	XP_009301340.1	Gene:	nlgn2a / 556158	ZFINID:	ZDB-GENE-090918-2	Length:	828	Species:	Danio rerio

Alignment Length:	925	Identity:	288/925 - (31%)
Similarity:	415/925 - (44%)	Gaps:	249/925 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TVLISW--MHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPP 79
            |:.:.|  :....||...|..|.:  :..|.|.||:|.|:...|:: ..|..||.:|||||||.|
Zfish    22 TIALFWLALWITLASCQRIDPGTK--YPTVTTNYGKLRGIKKELNN-EILGPVEQYLGVPYATAP 83

  Fly    80 TKQNRFSPTRAPAPWDGIRISDKYSPVCPQR----LPNIQNETAALEKMPKGRLEYLKRLLPFLE 140
            ....||.|..||..|..:|.:.:::|||||.    ||.|.        :|....:.|.....:::
Zfish    84 IGDRRFQPPEAPGSWQEVRNATQFAPVCPQNVHGVLPEIM--------LPVWFTDSLDVAATYIQ 140

  Fly   141 NQSEDCLYLNVFSPVNAG-------------------ANEKKLPVIVFIHGESFEWSSGNPYDGS 186
            |||||||||||:.|...|                   .:.:|.||::||||.|:...:||.:|.|
Zfish   141 NQSEDCLYLNVYVPTEDGPLTKKHDESTLNRPRDEDIRDRRKKPVMLFIHGGSYMEGTGNMFDAS 205

  Fly   187 VLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVT 251
            |||:||.|:|||:|||||:||||:...    .:...||||:||:.||.|:.:||..|||||..:|
Zfish   206 VLAAYGNVIVVTMNYRLGVLGFLSTGD----QSAKGNYGLLDQIQALRWLNENIGHFGGDPERIT 266

  Fly   252 LAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDIN 316
            :.|.|.||:|:|.|:.|... .|||.|||..||||.|||::...|:.:...||::|.||..:..:
Zfish   267 IFGSGAGASCVNLLILSHHS-EGLFQRAIAQSGSAISSWSISYQPLKYTKILARKVGCTYGETAD 330

  Fly   317 RHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADS 381
                 :|||||.....:|...|||...:..:|||.:||.|:..     |.:.||.:
Zfish   331 -----LVDCLRRKNFRELVDQDIQPARYHIAFGPVMDGDVVPD-----DPEILMQQ--------- 376

  Fly   382 GFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRF--- 443
                                          |.|       :|    ||:|.||..||.: :|
Zfish   377 ------------------------------GEF-------LN----YDLLIGVNQGEGL-KFVDD 399

  Fly   444 SAHDIQNGFEGERRDKIIRTYVRNAYNYH-----LNEIFYTIVNEYTDW-DRTSQHPINTRDTAV 502
            ...:.:.|......|..|..:|.|.|.|.     |.|   ||...|||| ||.:..  ..|.|.:
Zfish   400 GGTESEEGISAAAFDYTISNFVDNLYGYPKGKDILRE---TIKFMYTDWADRDNGE--MRRKTLL 459

  Fly   503 AALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTK 567
            |..:|.|:|||.:                          |.|...|....|   .|||.|.:..:
Zfish   460 ALFTDHQWVAPAI--------------------------ATAKLHADYQSP---VYFYTFYHHCQ 495

  Fly   568 DGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQ 632
            ....|:.....||:::||:||.|::.....||.|::|::..||..||.:|||||:||:||....|
Zfish   496 TETRPEWADAAHGDEIPYVFGVPMIGATDLFPCNFSKNDIMLSAVVMTYWTNFAKTGDPNLPVPQ 560

  Fly   633 DSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVI 697
            |:.. :..:.|||..:.|..::...::||.||:||||::::||::::.||.|:|.|
Zfish   561 DTKF-IHTKPNRFEEVIWTKFNSKDKQYLHIGLKPRIRDNYRANKVAFWLELVPHL--------- 615

  Fly   698 ARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAY 762
              |||   |:::           |..:|.....|::.:..              .||:|..
Zfish   616 --HNL---HEEV-----------FSTATTRLPPGTARTPH--------------WKGQGPR---- 646

  Fly   763 LNGILGVTTVEPNNMYTTCIPIGGNY----SSSGGVFAPTTLANASSDTLASGFEAAGYAAYSTA 823
                   ||..|       ||...:.    ||....|.|     ..|||          ..|||.
Zfish   647 -------TTRHP-------IPTFPSELDPDSSEQPRFPP-----FPSDT----------RDYSTE 682

  Fly   824 LSVTIAIGCSLLILNVLIFAGVYYQRDKT------RL-----------------EVKTLQKQYQQ 865
            ||||:|:|.|||.||:|.||.:||:|||.      ||                 |:.:||.::.:
Zfish   683 LSVTVAVGASLLFLNILAFAALYYKRDKRHEMRRHRLSPQRGVAANDLAHSQEEEIMSLQMKHSE 747

  Fly   866 RSLHQQVPYPPEPIK 880
            ...|..:    ||::
Zfish   748 HDAHHDM----EPLR 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	225/669 (34%)
nlgn2a	XP_009301340.1	COesterase	47..608	CDD:306613	225/670 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1641
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.830