DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and NLGN3

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_851820.1	Gene:	NLGN3 / 54413	HGNCID:	14289	Length:	848	Species:	Homo sapiens

Alignment Length:	952	Identity:	297/952 - (31%)
Similarity:	412/952 - (43%)	Gaps:	276/952 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCP 108
            |.|.:|:|.|..:||.| ..|..|:.:||||||.||..:.||.|...|..|.|||.:..:.||||
Human    44 VNTHFGKLRGARVPLPS-EILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCP 107

  Fly   109 QRLPNIQNETAALEKM-PKGRLEYLKRLLPFLENQSEDCLYLNVFSPV----------------- 155
            |.:     .||..|.| |......|..:..:::..:||||||||:.|.
Human   108 QNI-----HTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKK 167

  Fly   156 ---NAGANEKK---------------------LPVIVFIHGESFEWSSGNPYDGSVLASYGEVVV 196
               ..|:..||                     .||:|:|||.|:...:||..|||:|||||.|:|
Human   168 ICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIV 232

  Fly   197 VTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAAC 261
            :|||||:|:||||:...    .|...||||:||:.||.|:.:||..|||||..:|:.|.|.||:|
Human   233 ITLNYRVGVLGFLSTGD----QAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASC 293

  Fly   262 INYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCL 326
            :: |:|......|||.|||:.||||.||||:...||.:...||.:|.|.:.|.::     :||||
Human   294 VS-LLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVD-----MVDCL 352

  Fly   327 RDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGG 391
            |....::|...|||...:..:|||.:||.||..     |.:.||.:
Human   353 RQKSAKELVEQDIQPARYHVAFGPVIDGDVIPD-----DPEILMEQ------------------- 393

  Fly   392 GQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRF--SAHDIQNGFEG 454
                                |.|       :|    ||::.||..||.: :|  ...|.::|..|
Human   394 --------------------GEF-------LN----YDIMLGVNQGEGL-KFVEGVVDPEDGVSG 426

  Fly   455 ERRDKIIRTYVRNAYNY-----HLNEIFYTIVNEYTDW-DRTSQHPINTRDTAVAALSDAQFVAP 513
            ...|..:..:|.|.|.|     .|.|   ||...|||| ||  .:|...|.|.||..:|.|:|.|
Human   427 TDFDYSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDWADR--DNPETRRKTLVALFTDHQWVEP 486

  Fly   514 IVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTV 578
            .|...|:.|           ..|||                  .|||.|.:..:....|......
Human   487 SVVTADLHA-----------RYGSP------------------TYFYAFYHHCQSLMKPAWSDAA 522

  Fly   579 HGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERN 643
            ||:::||:||.|:|.....||.|::|::..||..||.:|||||:||:||:...||:.. :..:.|
Human   523 HGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKF-IHTKAN 586

  Fly   644 RFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDD 708
            ||..:.|..|:|..|.||.||:|||:::|:||.:::.|..|:|.|:..        |::|  |..
Human   587 RFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNL--------HDMF--HYT 641

  Fly   709 MDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVE 773
            ....:.| .||                ::.||.:                            |..
Human   642 STTTKVP-PPD----------------TTHSSHI----------------------------TRR 661

  Fly   774 PNNMYTTCIPIGGNYSSSGGVFAPTTLANASSDTLASGFEAAGYAA------YSTALSVTIAIGC 832
            ||         |..:|:.....:| ..:|.::....:|.:.||...      |||.||||||:|.
Human   662 PN---------GKTWSTKRPAISP-AYSNENAQGSWNGDQDAGPLLVENPRDYSTELSVTIAVGA 716

  Fly   833 SLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQRSLHQQVPYPPEPIKHAHYHMGHSQSSANVIV 897
            |||.||||.||.:||::||.|           |..|.|     |.|
Human   717 SLLFLNVLAFAALYYRKDKRR-----------QEPLRQ-----PSP------------------- 746

  Fly   898 DVESHQDQAGQAAMLLQAAAAAAAAAA------NDVKPPPPH 933
                   |.|..|..|.||.....||.      ::.:..|||
Human   747 -------QRGAGAPELGAAPEEELAALQLGPTHHECEAGPPH 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	235/686 (34%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	235/686 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..195		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..694		13/103 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23133
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1598
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.830