DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and ACHE

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_001354847.1	Gene:	ACHE / 43	HGNCID:	108	Length:	681	Species:	Homo sapiens

Alignment Length:	709	Identity:	201/709 - (28%)
Similarity:	278/709 - (39%)	Gaps:	177/709 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SQLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVE 68
            |.|||||..||           .|...|:..:.|.|   :|..|.|||.|:.|....    ..|.
Human    82 SPLLLLLLWLL-----------GGGVGAEGREDAEL---LVTVRGGRLRGIRLKTPG----GPVS 128

  Fly    69 VFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLK 133
            .|||:|:|.||....||.|.....||.|:..:..:..||.|                     |:.
Human   129 AFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTFQSVCYQ---------------------YVD 172

  Fly   134 RLLPFLENQ---------SEDCLYLNVFSPVNAGANEKKLPVIVFIHGESF--EWSSGNPYDGSV 187
            .|.|..|..         |||||||||::|.....:  ..||:|:|:|..|  ..||.:.|||..
Human   173 TLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTS--PTPVLVWIYGGGFYSGASSLDVYDGRF 235

  Fly   188 LASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTL 252
            |......|:|::|||:|..|||..   |.:.....|.||:||..||.|:|:|:..|||||.||||
Human   236 LVQAERTVLVSMNYRVGAFGFLAL---PGSREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTL 297

  Fly   253 AGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALV--EDPVLFAIKLAKEVNCTIPDDI 315
            .|...|||.:...:.||.. |||||||:|.||:....||.|  .:....|.:||..|.|. |...
Human   298 FGESAGAASVGMHLLSPPS-RGLFHRAVLQSGAPNGPWATVGMGEARRRATQLAHLVGCP-PGGT 360

  Fly   316 NRHHEQIVDCLRDVPLEDLYLAD----IQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRR 376
            ..:..::|.|||..|.:.|...:    .|...|..||.|.||
Human   361 GGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRFSFVPVVD----------------------- 402

  Fly   377 SSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHY--DVLFGVVTGES 439
                                              |.:...:....:|.|..:  .||.|||..|.
Human   403 ----------------------------------GDFLSDTPEALINAGDFHGLQVLVGVVKDEG 433

  Fly   440 IWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEI----FYTIVNEYTDWDRTSQHPINTRDT 500
            .: |..:... ||..:....|.|..........:.::    ...:|..|||| ...:.|...|:.
Human   434 SY-FLVYGAP-GFSKDNESLISRAEFLAGVRVGVPQVSDLAAEAVVLHYTDW-LHPEDPARLREA 495

  Fly   501 AVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQ 565
            ....:.|...|.|:.:....|||.              ||               |.|.|||:::
Human   496 LSDVVGDHNVVCPVAQLAGRLAAQ--------------GA---------------RVYAYVFEHR 531

  Fly   566 TKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHH 630
            .....:|..||..||.::.:|||.||...     :|||..|...::.:|.:|.||||||:|||
Human   532 ASTLSWPLWMGVPHGYEIEFIFGIPLDPS-----RNYTAEEKIFAQRLMRYWANFARTGDPNE-- 589

  Fly   631 RQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKP-RIKNHFRAHQLSIWLRLIPEL 688
            .:|...|           .|..|....|:|:.:.::| .::...||...:.|.|.:|:|
Human   590 PRDPKAP-----------QWPPYTAGAQQYVSLDLRPLEVRRGLRAQACAFWNRFLPKL 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	185/661 (28%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	187/667 (28%)
ACHE	NP_001354847.1	AChE_tetra	645..678	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910