DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and Ace

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_001163600.1	Gene:	Ace / 41625	FlyBaseID:	FBgn0000024	Length:	649	Species:	Drosophila melanogaster

Alignment Length:	795	Identity:	181/795 - (22%)
Similarity:	283/795 - (35%)	Gaps:	250/795 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPP 79
            ||.||:..:|.:|....       :...:|||..|.:.|..:.:..    |.|.|:.|:|||.||
  Fly    23 LPLVLVLSLHLSGVCGV-------IDRLVVQTSSGPVRGRSVTVQG----REVHVYTGIPYAKPP 76

  Fly    80 TKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYL-----KRLLPFL 139
            .:..||.......||.|:..:.:.|..|.|.                 |.||.     :.:....
  Fly    77 VEDLRFRKPVPAEPWHGVLDATRLSATCVQE-----------------RYEYFPGFSGEEIWNPN 124

  Fly   140 ENQSEDCLYLNVFSPVNA------GAN------------------------EKKLPVIVFIHGES 174
            .|.||||||:||::|..|      |||                        ...||::::|:|..
  Fly   125 TNVSEDCLYINVWAPAKARLRHGRGANGGEHPNGKQADTDHLIHNGNPQNTTNGLPILIWIYGGG 189

  Fly   175 FEWSSG--NPYDGSVLASYGEVVVVTLNYRLGILGFLNANPN-PHAHARVA--NYGLMDQMAALH 234
            |...|.  :.|:..::|:.|.|:|.:..||:|..|||:..|. |...|..|  |.||.||..|:.
  Fly   190 FMTGSATLDIYNADIMAAVGNVIVASFQYRVGAFGFLHLAPEMPSEFAEEAPGNVGLWDQALAIR 254

  Fly   235 WIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALV--EDPV 297
            |::.|...|||:|..:||.|...|::.:|..:.|| :.|||..|.::.||:..:.|:.:  |..|
  Fly   255 WLKDNAHAFGGNPEWMTLFGESAGSSSVNAQLMSP-VTRGLVKRGMMQSGTMNAPWSHMTSEKAV 318

  Fly   298 LFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSF--GPSVDGVVIRPG 360
            .....|..:.||. ...:..:...::.|:|.|..:.:.:....:.:.:.||  .|::||..:...
  Fly   319 EIGKALINDCNCN-ASMLKTNPAHVMSCMRSVDAKTISVQQWNSYSGILSFPSAPTIDGAFLPAD 382

  Fly   361 HSNL----DIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGT 421
            ...|    |:.|
  Fly   383 PMTLMKTADLKD----------------------------------------------------- 394

  Fly   422 MNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYV-RNAYNYHLNEIF-------- 477
                  ||:|.|.|..|..: |..:|..:.|     ||...|.: |:.|...:|.||
  Fly   395 ------YDILMGNVRDEGTY-FLLYDFIDYF-----DKDDATALPRDKYLEIMNNIFGKATQAER 447

  Fly   478 YTIVNEYTDWDRT----SQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSP 538
            ..|:.:||.|:..    :|..|.      .|:.|..|..|.......||..
  Fly   448 EAIIFQYTSWEGNPGYQNQQQIG------RAVGDHFFTCPTNEYAQALAER-------------- 492

  Fly   539 GANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYT 603
            ||:.               ::|.|.::|....:.:.||.:||:::.|.||.||.:...:.|....
  Fly   493 GASV---------------HYYYFTHRTSTSLWGEWMGVLHGDEIEYFFGQPLNNSLQYRPVERE 542

  Fly   604 KSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPR 668
            ..:..||..:     .||:||||    .||..             .|.|:......|.......:
  Fly   543 LGKRMLSAVI-----EFAKTGNP----AQDGE-------------EWPNFSKEDPVYYIFSTDDK 585

  Fly   669 IKNHFR---AHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGAS 730
            |:...|   |.:.|.|...:|::.                                  |.|....
  Fly   586 IEKLARGPLAARCSFWNDYLPKVR----------------------------------SWAGTCD 616

  Fly   731 GSSSSSSSSSRLLLV 745
            |.|.|:|.|.||.|:
  Fly   617 GDSGSASISPRLQLL 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	163/701 (23%)
Ace	NP_001163600.1	COesterase	41..601	CDD:278561	163/704 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910