DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and alpha-Est6

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	723	Identity:	176/723 - (24%)
Similarity:	257/723 - (35%)	Gaps:	246/723 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CAGASTADIYKGARLGHRIVQTRYG-----RLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNR 84
            |..|..||        .::|:...|     ||.|:.  .|.|      ..|.|:|:|.||..:.|
  Fly    32 CQSAGDAD--------SKVVKLSVGSVKGRRLSGIY--GDEF------YSFEGIPFAKPPLGKAR 80

  Fly    85 FSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQ------- 142
            |..::...||:                    :|..|.::.|          :|...::
  Fly    81 FVASQLADPWN--------------------SELDARQERP----------IPLQMDRRSGKVVG 115

  Fly   143 SEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYG-------EVVVVTLN 200
            |||||||||::. :...:|..|||:|:|:|.:|...      |:|.:.||       :||.|..|
  Fly   116 SEDCLYLNVYTK-HFNESEPPLPVMVYIYGGAFRTG------GAVKSKYGPDYLMSRDVVYVLFN 173

  Fly   201 YRLGILGFLNANPNPHAHARV-ANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINY 264
            |||..||||:.   |.....| .|.||.||:.||.|:.|:|:.|.|||.::||.|...|||.:::
  Fly   174 YRLCSLGFLSM---PSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAGAASVHF 235

  Fly   265 LMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDV 329
            :|..| ..:||||:||:||||..|.|....|......:||.......|.:    ...|::.||:|
  Fly   236 MMCLP-QAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYEGPAE----EVPILEFLRNV 295

  Fly   330 PLEDLYLADIQAP-----NFLTSFGPSVDGVVIRPGHS------NLDIDDLMARNSRRSSADSGF 383
            ..|.|...|..:|     .||..|.|.|.|:|..|...      :.::..|:
  Fly   296 NAEKLIGHDFISPRDRCFGFLNPFAPVVGGLVAAPFQQLMKEAWSCEVPLLL------------- 347

  Fly   384 QSSAGGGGGQGGGAGGGGGGGSGSSFGG-----------GYFGGSGAGTMNMGGHYDVLFGVVTG 437
                                 .|:||.|           ||.       :.:..|...:
  Fly   348 ---------------------GGTSFEGLVYYPFCQLDNGYM-------LELLKHEPAM------ 378

  Fly   438 ESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTD-------WDRTSQHPI 495
                 ...|::......|.|:......|:  |:|....|..:.:.:..|       |     |.|
  Fly   379 -----VLPHELYQSMSVEERNTAADVLVK--YHYGPRGITKSNITQILDLFSYKLFW-----HGI 431

  Fly   496 NTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFY 560
            :.  ..::.||.||  ||                                           .|.|
  Fly   432 HR--VVLSRLSHAQ--AP-------------------------------------------TYLY 449

  Fly   561 VFDYQTKD---------GDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIF 616
            .||:.:..         ||..:| |..|.:||.|||...     :...|.....|....:.::..
  Fly   450 RFDFDSPKLNLMRNQLCGDDIKR-GVCHADDLGYIFHKQ-----AQAKQPLDSPEFLTIQRMVGI 508

  Fly   617 WTNFARTGNPN-EHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSI 680
            .|.|||||:|| .....|..:|||.:            .|.  |.|.||.:...........|.:
  Fly   509 LTTFARTGDPNCPETGPDPWMPVSTK------------SPF--KALNIGQQVECVTQVEKDGLKV 559

  Fly   681 WLRLIPEL 688
            |.||..:|
  Fly   560 WNRLYSDL 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	168/696 (24%)
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	165/671 (25%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	76/205 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810