DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nlg4 and Ces3a

DIOPT Version :10

Sequence 1:NP_001369025.1 Gene:Nlg4 / 42402 FlyBaseID:FBgn0083975 Length:1437 Species:Drosophila melanogaster
Sequence 2:NP_941074.1 Gene:Ces3a / 382053 MGIID:102773 Length:571 Species:Mus musculus


Alignment Length:702 Identity:195/702 - (27%)
Similarity:279/702 - (39%) Gaps:186/702 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGL---ILPLDSFRFLRSVEVFLGV 73
            ||:.||.:|               |.::....|.|..||:.|.   :...|     |.|.||||:
Mouse    22 LLIFPTTVI---------------GPKVTQPEVDTPLGRVRGRQVGVKDTD-----RMVNVFLGI 66

  Fly    74 PYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAAL-EKMPKGRLEYLKRLLP 137
            |:|..|....|||....|.||:|:|.:....|:|.|.:..:.|....| |||         ::.|
Mouse    67 PFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQDVERMSNSRFTLNEKM---------KIFP 122

  Fly   138 FLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYR 202
            .    |||||.||::||....|.:|: ||:|:|||.|....|...:|||.||:||:|||||:.||
Mouse   123 I----SEDCLTLNIYSPTEITAGDKR-PVMVWIHGGSLLVGSSTSHDGSALAAYGDVVVVTVQYR 182

  Fly   203 LGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMT 267
            |||.|||:.. :.|   ...|.|.:|.:|||.|:|.||..||||||.||:.|:..|...::.|:.
Mouse   183 LGIFGFLSTG-DKH---MPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLL 243

  Fly   268 SPTMVRGLFHRAILMSGSAYSSWALVEDPVLF--AIKLAKEVNCTIPDDINRHHEQIVDCLRDVP 330
            || |..|||||||..||...|.  ::||...:  |...|..|.|.     :....::|.||....
Mouse   244 SP-MSAGLFHRAISQSGVVISK--ILEDLNAWSEAQNFANSVACG-----SASPAELVQCLLQKE 300

  Fly   331 LEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGG 395
            .:||    |...|...|:..:               |....:..::..|:..|.:          
Mouse   301 GKDL----ITKKNVNISYTVN---------------DSFFPQRPQKLLANKQFPT---------- 336

  Fly   396 GAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIW---RFSAHDIQNGFEGERR 457
                                            ...|.||...|..|   :|  .:|.:..|...:
Mouse   337 --------------------------------VPYLLGVTNHEFGWLLLKF--WNILDKMEHLSQ 367

  Fly   458 DKIIRTYVRNAYNYHLN---EIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGD 519
            :.::..  ......|:.   ||..|:::||.|   .......||......|.|...|.|.:....
Mouse   368 EDLLEN--SRPLLAHMQLPPEIMPTVIDEYLD---NGSDESATRYALQELLGDITLVIPTLIFSK 427

  Fly   520 ILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDY----PQRMGTVHG 580
            .|                              |.:| |..:::::|.....:    |..:...|.
Mouse   428 YL------------------------------QDAG-CPVFLYEFQHTPSSFAKFKPAWVKADHS 461

  Fly   581 EDLPYIFGAPLVDGFSH---FPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKER 642
            .:..::||.|.:...|.   ||: .|:.|..||..:|..|:.||||||||     ...||     
Mouse   462 SENAFVFGGPFLTDESSLLAFPE-ATEEEKQLSLTMMAQWSQFARTGNPN-----GKGLP----- 515

  Fly   643 NRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIP----ELHR 690
                  .|...:.|.| |||||::||.....:..:|..|...:|    |.||
Mouse   516 ------PWPQLNQLEQ-YLEIGLEPRTGVKLKKGRLQFWTETLPRKIQEWHR 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nlg4NP_001369025.1 COesterase 43..681 CDD:395084 184/656 (28%)
Ces3aNP_941074.1 COesterase 36..547 CDD:395084 184/658 (28%)
Prevents secretion from ER. /evidence=ECO:0000255 568..571
Blue background indicates that the domain is not in the aligned region.

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