DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nlg4 and Ces3a

DIOPT Version :9

Sequence 1:NP_001369025.1 Gene:Nlg4 / 42402 FlyBaseID:FBgn0083975 Length:1437 Species:Drosophila melanogaster
Sequence 2:NP_941074.1 Gene:Ces3a / 382053 MGIID:102773 Length:571 Species:Mus musculus


Alignment Length:702 Identity:195/702 - (27%)
Similarity:279/702 - (39%) Gaps:186/702 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 LLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGL---ILPLDSFRFLRSVEVFLGV 73
            ||:.||.:|               |.::....|.|..||:.|.   :...|     |.|.||||:
Mouse    22 LLIFPTTVI---------------GPKVTQPEVDTPLGRVRGRQVGVKDTD-----RMVNVFLGI 66

  Fly    74 PYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAAL-EKMPKGRLEYLKRLLP 137
            |:|..|....|||....|.||:|:|.:....|:|.|.:..:.|....| |||         ::.|
Mouse    67 PFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQDVERMSNSRFTLNEKM---------KIFP 122

  Fly   138 FLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYR 202
            .    |||||.||::||....|.:|: ||:|:|||.|....|...:|||.||:||:|||||:.||
Mouse   123 I----SEDCLTLNIYSPTEITAGDKR-PVMVWIHGGSLLVGSSTSHDGSALAAYGDVVVVTVQYR 182

  Fly   203 LGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMT 267
            |||.|||:.. :.|   ...|.|.:|.:|||.|:|.||..||||||.||:.|:..|...::.|:.
Mouse   183 LGIFGFLSTG-DKH---MPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLL 243

  Fly   268 SPTMVRGLFHRAILMSGSAYSSWALVEDPVLF--AIKLAKEVNCTIPDDINRHHEQIVDCLRDVP 330
            || |..|||||||..||...|.  ::||...:  |...|..|.|.     :....::|.||....
Mouse   244 SP-MSAGLFHRAISQSGVVISK--ILEDLNAWSEAQNFANSVACG-----SASPAELVQCLLQKE 300

  Fly   331 LEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGG 395
            .:||    |...|...|:..:               |....:..::..|:..|.:          
Mouse   301 GKDL----ITKKNVNISYTVN---------------DSFFPQRPQKLLANKQFPT---------- 336

  Fly   396 GAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIW---RFSAHDIQNGFEGERR 457
                                            ...|.||...|..|   :|  .:|.:..|...:
Mouse   337 --------------------------------VPYLLGVTNHEFGWLLLKF--WNILDKMEHLSQ 367

  Fly   458 DKIIRTYVRNAYNYHLN---EIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGD 519
            :.::..  ......|:.   ||..|:::||.|   .......||......|.|...|.|.:....
Mouse   368 EDLLEN--SRPLLAHMQLPPEIMPTVIDEYLD---NGSDESATRYALQELLGDITLVIPTLIFSK 427

  Fly   520 ILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDY----PQRMGTVHG 580
            .|                              |.:| |..:::::|.....:    |..:...|.
Mouse   428 YL------------------------------QDAG-CPVFLYEFQHTPSSFAKFKPAWVKADHS 461

  Fly   581 EDLPYIFGAPLVDGFSH---FPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKER 642
            .:..::||.|.:...|.   ||: .|:.|..||..:|..|:.||||||||     ...||     
Mouse   462 SENAFVFGGPFLTDESSLLAFPE-ATEEEKQLSLTMMAQWSQFARTGNPN-----GKGLP----- 515

  Fly   643 NRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIP----ELHR 690
                  .|...:.|.| |||||::||.....:..:|..|...:|    |.||
Mouse   516 ------PWPQLNQLEQ-YLEIGLEPRTGVKLKKGRLQFWTETLPRKIQEWHR 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nlg4NP_001369025.1 COesterase 43..681 CDD:395084 184/656 (28%)
Ces3aNP_941074.1 COesterase 36..547 CDD:278561 184/658 (28%)
Aes 75..>245 CDD:223730 78/187 (42%)
Prevents secretion from ER. /evidence=ECO:0000255 568..571
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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