Protein Alignment Nlg4 and CG12869

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_001369085.1
• Gene: CG12869 / 36616
• FlyBaseID: FBgn0033943
• Length: 839
• Species: Drosophila melanogaster
• Alignment Length: 1221
• Identity: 257/1221 - (21%)
• Similarity: 398/1221 - (32%)
• Gaps: 471/1221 - (38%)

  Fly     5 QLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEV 69
            |:|.||.:|:         |.:.      |..|:..|  ::...|.|.||.:..|..|  .:|..
  Fly     9 QILRLLPILI---------HLSP------YISAQQTH--IKLEQGDLIGLKVFPDGTR--GAVYA 54

  Fly    70 FLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKR 134
            |||:|||..|..:.||:|.:..:.::....:....|:|||....|.:|::. ..||:.
  Fly    55 FLGIPYAQAPINELRFAPAKPSSSFNRTLQATTMQPLCPQLANTIYDESSD-GSMPRS------- 111

  Fly   135 LLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESF--EWSSGNPYDGSVLASYGEVVVV 197
                 .:..|||||||:::| .:|....|||::|.:.||.|  :|.. |..:|..||..| :|||
  Fly   112 -----VSTDEDCLYLNIWTP-ESGMRYGKLPIVVIVTGEEFAYDWPR-NRINGLDLAGEG-IVVV 168

  Fly   198 TLNYRLGILGFLNANPNPHAHARV-ANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAAC 261
            ::.||..|.|:|:..   ..|..| .||||.|...||.||::|...|||:|:.:||.|||:|.|.
  Fly   169 SVQYRNNIYGWLSLG---EQHRNVPGNYGLSDVQMALRWIRRNADAFGGNPDHITLLGHGSGGAP 230

  Fly   262 INYLMT--SPTMVRGLFHRAILMS--------GSAYSSWALVEDPVLFAIKLAKEVNCTIPDDIN 316
            :..:.|  ..:.|:.|    :|||        |..:..|.:....|     |.:::.|...:...
  Fly   231 LALVATLEDSSQVKQL----VLMSPGPIMRALGQNHQKWIVETGQV-----LVQKLGCQFEEAQR 286

  Fly   317 RHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADS 381
            |   |::.|||....|||..|.....|.  ..|.|..||::..|   |.::..: ||........
  Fly   287 R---QLMGCLRRKSREDLLRAYESVYNH--GNGSSQLGVILPEG---LPLEQRL-RNKTLPPVLL 342

  Fly   382 GFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYF---GGSGAGTMNMGGHYDVLFGVVTG-ESI-- 440
            |..|:.|                   :|...|:   ...|...::...::.:|..|:.. ||:
  Fly   343 GITSNEG-------------------AFLQDYWLDVAREGQVALHKYINHTLLPNVMRALESVGE 388

  Fly   441 ----------WRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPI 495
                      ||:.     || :||....::....|
  Fly   389 ESSTQLAAIRWRYF-----NG-KGEGVSHLLAGMQR----------------------------- 418

  Fly   496 NTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFY 560
                    .||::.:..|..|..::|                          .|:|.     |.|
  Fly   419 --------LLSESLYELPYSRILELL--------------------------NGTTS-----YAY 444

  Fly   561 VFDYQTKDGDYPQRM----GTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFA 621
            |||: :...|...|.    |..|..|||.:.|..|....:.  :.::..|..|...:...:.||.
  Fly   445 VFDH-SHSMDMRGRRNLFGGASHSSDLPLLLGPSLFQQIAR--RRFSGEEEQLCRKIRGAFANFI 506

  Fly   622 RTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIP 686
            :.|||......|..||.:||
  Fly   507 KNGNPTPGRIYDGWLPYNKE--------------------------------------------- 526

  Fly   687 ELHRAGMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMM 751
                                            :||..|....|....:.|        |||..:.
  Fly   527 --------------------------------NPFVYSLGEQAKTPQTGS--------VDEAEVD 551

  Fly   752 KKGRGLNGSAYLNGILGVTT------VEPNNMYTTCIPIGGNYSS-------------------- 790
            |..||..|:..|:..|..:.      ..|:|.||....:...||:
  Fly   552 KLLRGETGAPGLDRSLSRSNRHDTYRAAPSNSYTASNQLDSGYSNHLQMVYGFWQVLMPLEREED 616

  Fly   791 --SGGVFAP-TTLANASSDTLASGFEAAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKT 852
              .||.... ..|..||:|  |:.:....||          .:|...|:|..|.......:||..
  Fly   617 LRGGGALGQRVRLLEASAD--AARYRQGFYA----------MLGLVCLLLACLCLCVYLLKRDPN 669

  Fly   853 RLEVKTLQKQYQQRSL-HQ-------------QVPYPPEPIKHAHYHMGHSQSSANVIVDVESHQ 903
            .:..::........|| |:             :||                  |.:.|.:|||.:
  Fly   670 AMRRRSASSASDCYSLXHKWFRWTTIFGGRKDEVP------------------STSGIANVESWR 716

  Fly   904 DQAGQAAMLLQAAAAAAAAAANDVKPPPPHICSNTGMQQQQQVGGG---SGGALNNGGIEGSKVT 965
             :.|:|.                               :::|.|.|   |||  .:|.:||
  Fly   717 -KGGRAT-------------------------------KREQDGSGAVESGG--GDGNLEG---- 743

  Fly   966 TDNLGNVTYSTSSKQQQQHQQQQQQQQREHMQIKGMTGTQTFGRSGSGSGGGAGGGAGSASGGAS 1030
                         ::::|...:|:.::...:|......|...|    |:|.|||.|.|:|.|
  Fly   744 -------------ERREQVLNKQRTRRPRQLQPYDFKITHPIG----GAGVGAGFGTGTAGG--- 788

  Fly  1031 VVVSGSSVSYNPGMMTLPKSGGLHHAATLNYARNTTALNMSGGGTALVDSRGNVLLTSTAVGPGM 1095
                                           .||       ||||                   .
  Fly   789 -------------------------------VRN-------GGGT-------------------R 796

  Fly  1096 AGTGAG-GGSSGGGGGGDCMTLPRNLGLAAAGRHNPTTELQQYQQQQQSSK 1145
            |||.:| ||:.|        |:...|. ..||:..|:..::.:|.|....|
  Fly   797 AGTVSGFGGTLG--------TVEELLD-PVAGQFEPSVAVRNWQYQLTCDK 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	157/670 (23%)
CG12869	NP_001369085.1	COesterase	27..541	CDD:395084	162/727 (22%)