DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and CG9289

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_609245.1	Gene:	CG9289 / 34195	FlyBaseID:	FBgn0032058	Length:	674	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	182/727 - (25%)
Similarity:	261/727 - (35%)	Gaps:	250/727 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 GRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAP-WDGIRISDKYSPVCPQRLP 112
            |||.|..|..|...  :.:..||.:||.    |..||.|.. ||| |.|:..:.:....|    |
  Fly    84 GRLRGRTLTTDWTG--QKIMQFLDIPYG----KAERFRPAE-PAPSWKGVLPAHRPHAGC----P 137

  Fly   113 NIQNETAALEKMPKGRLEYLKRLLPF--LENQS---EDCLYLNVFSPVNAGANE-KKLPVIVFIH 171
            :||:                  |:.|  ||...   ||||.|:    ||..|.| |.|||:|:||
  Fly   138 SIQD------------------LIVFAKLEEDGFDVEDCLRLS----VNTKAMEGKSLPVMVYIH 180

  Fly   172 GESFEWSSGNPYDG-SVLASYG-----EVVVVTLNYRLGILGFLN--ANPNPHAHARVANYGLMD 228
            |:.|       ||| ||.|:.|     :||:|::.||||..|||:  .:..|      .|..:.|
  Fly   181 GDFF-------YDGDSVEAAPGYLLEHDVVLVSVRYRLGPFGFLSTLTDEMP------GNAAVTD 232

  Fly   229 QMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALV 293
            .:.||.|:||:|..|||||..|||.|...|||.:|.|..||.:..|||||.|..||:|.|. |.:
  Fly   233 IILALKWVQQHIASFGGDPQRVTLFGQVGGAALVNVLTLSPAVPAGLFHRVIYQSGTALSP-AFI 296

  Fly   294 EDPVLFAIK-LAKEVNC---TIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDG 354
            .|..|.|.| :.:...|   |..|.:|:       ||.          .:.|...|.:|  ||.
  Fly   297 TDAPLGATKAIGRIAGCKQSTKVDQLNK-------CLN----------RLNATMLLAAF--SVH- 341

  Fly   355 VVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGA 419
                                                            |.:..|..||.:||.
  Fly   342 ------------------------------------------------GENQPSLSGGAYGGV-- 356

  Fly   420 GTMNMGGHYDVL----FGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTI 480
             .:.:||...:|    ..::..|   :|.|:....|            .|::...:.|.:||..|
  Fly   357 -QLVIGGPSGILPEHPGRLLAAE---KFQAYPTMGG------------SVKHGGTFMLRDIFADI 405

  Fly   481 VNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAG--------- 536
            .|| |..|.|              ::..|::..|:.     .||...|..|.....
  Fly   406 FNE-TILDDT--------------MTGRQYIDTIIE-----QANGADPSGSWKEFSDEEIFTQND 450

  Fly   537 ---------SPGANAAAST-----------SAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGE 581
                     :||.....||           .|.:.:.....|.|.|||:.:...|      ..||
  Fly   451 VKNGTFKRLTPGLIDLCSTISLKNPVLLVLQANAKKLPNSTYLYSFDYEGEQNRY------ATGE 509

  Fly   582 D----LPYIFGAPLVDG------FSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSL 636
            |    :|:..|..|.|.      :..|....:..:..::..::..||:||.||.|     |...|
  Fly   510 DEANFVPFDMGVSLTDDNLYLFPWPRFLALNSNRDLKVARRMVALWTSFATTGVP-----QAPGL 569

  Fly   637 PVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHN 701
            |           .|...:.....|::|.......:::.            :.:|..:|:....:|
  Fly   570 P-----------AWPAMNDETGPYMKIDRTVSFGDNYL------------DEYRIAVEEAKHGYN 611

  Fly   702 LFRNHDDMDLYE 713
            |. |.:..||.|
  Fly   612 LV-NDEYYDLQE 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	174/693 (25%)
CG9289	NP_609245.1	COesterase	83..600	CDD:278561	174/702 (25%)
CG9289	NP_609245.1	Aes	<171..351	CDD:223730	79/261 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.900