Protein Alignment Nlg4 and Nlg3

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_061500330.1
• Gene: Nlg3 / 3290865
• VectorBaseID: AGAMI1_000316
• Length: 952
• Species: Anopheles gambiae
• Alignment Length: 1089
• Identity: 442/1089 - (40%)
• Similarity: 583/1089 - (53%)
• Gaps: 286/1089 - (26%)

  Fly     8 LLLRLLLLPTVLISWMHCAGASTADIYKGARLGH------------------------RIVQTRY 48
            :::.:::....|::.::.||:.::.....:..|:                        |||.|:|
Mosquito     6 VIIAVVVFTVSLVAPINSAGSGSSSSSSSSGSGNSPSNGGPGSNSMDENETLKKSTSSRIVHTKY 70

  Fly    49 GRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPN 113
            |.:.|.|..||. |.|..||.|.|||||:||....||.|....|.|.|::.:|::|||||||||:
Mosquito    71 GAVSGTIEHLDG-RHLDPVEAFRGVPYASPPVGNLRFMPPVTGALWSGVKKADRFSPVCPQRLPD 134

  Fly   114 IQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANE----KKLPVIVFIHGES 174
            |.|||||||:||:||||||:||||:|.||||||||||::.|..||:.|    .|..|:||:||||
Mosquito   135 IYNETAALERMPRGRLEYLRRLLPYLRNQSEDCLYLNIYVPTQAGSRESSSTSKYAVVVFVHGES 199

  Fly   175 FEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQN 239
            :||:||||||||||||||:::|||:|||||||||||||.:..:.| .|||||||.:|||||||:|
Mosquito   200 YEWNSGNPYDGSVLASYGQILVVTINYRLGILGFLNANVDRFSKA-PANYGLMDIIAALHWIQEN 263

  Fly   240 IQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRG-LFHRAILMSGSAYSSWALVEDPVLFAIKL 303
            |:.|||||.|||||||||||||:::|:.|..:..| ||||||:||||..:.|:||.:|..||..:
Mosquito   264 IEAFGGDPKSVTLAGHGTGAACVHFLIASAAVPEGLLFHRAIMMSGSGLAPWSLVGEPAKFAAYV 328

  Fly   304 AKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDD 368
            :..|||: ||   ..|:.::.||||.||||:....::||:|..:||||||||||..|    :|..
Mosquito   329 SHHVNCS-PD---LPHQLLLKCLRDKPLEDILSTSVRAPDFGNAFGPSVDGVVIDTG----EIQQ 385

  Fly   369 LMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGT------------ 421
            :                                   .|:.:..  :.|:.|.|
Mosquito   386 M-----------------------------------DGTHYSD--YSGNPAATKPSAHIHNTLNT 413

  Fly   422 ----------MNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEI 476
                      :|....||:|.||...|:.:.|::.|:|.|.|.:||.||::.|||:.|::|||||
Mosquito   414 INAILLRKLAINKLSKYDLLVGVTRAEAYFAFNSEDVQYGIEADRRAKILKNYVRSTYSFHLNEI 478

  Fly   477 FYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAA---NSPPPVSSSSTAGSP 538
            ..|||||||||:|..|||||.||..:.|||||:.|||.|:..|:.:|   ||
Mosquito   479 LATIVNEYTDWERPVQHPINIRDETLEALSDARIVAPAVQTADLHSADHRNS------------- 530

  Fly   539 GANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYT 603
                               :.||||||||.||:|||.|.:|||||||:||||||.||:||.:|||
Mosquito   531 -------------------FLYVFDYQTKFGDFPQRQGCIHGEDLPYLFGAPLVGGFNHFTRNYT 576

  Fly   604 KSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPR 668
            |||.||||||||:|:||.|||||||....|.    .::|.||::|.|..|:.:|:|||.:..||:
Mosquito   577 KSEIALSEAVMIYWSNFIRTGNPNEQLENDH----VRDRTRFKNIEWTPYESVHKKYLNLDTKPK 637

  Fly   669 IKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDLYEGP-----VKP------DPFG 722
            :|||:|||:||.||.|:|:||:.|.:||.:.|:...:.|:    |.|     |||      ||..
Mosquito   638 LKNHYRAHRLSFWLNLVPDLHKPGNDDVPSGHHELESDDE----EQPAALPTVKPLNPPQRDPAT 698

  Fly   723 ISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEPNNM--YTTCIPI- 784
            |       ||:.:..::....|            ||.|:|  |||      ||..  |....|:
Mosquito   699 I-------GSNYTLFTTQVFSL------------LNFSSY--GIL------PNGSRHYPGTRPVH 736

  Fly   785 -----------------GGNYSSSGGVFAPTTLANASSDTLASGFEAAGYAAYSTALSVTIAIGC 832
                             ||....:||:               |..:..|:|||||||||||||||
Mosquito   737 PVTAESSEGGDDDGGAAGGGAGGAGGM---------------SSSQEDGFAAYSTALSVTIAIGC 786

  Fly   833 SLLILNVLIFAGVYYQRDKTRLEVK--------------TLQKQYQQRSLHQQVPY--------- 874
            ||||||||||||||||||||||...              |||.  ::|:.:.|:|.
Mosquito   787 SLLILNVLIFAGVYYQRDKTRLNEPRGGGPGMGGPGGHGTLQT--KKRNENGQMPNNICGELESL 849

  Fly   875 -------PPEPIKHAHYHMGHSQSSANVIVDVESHQDQAGQAAMLLQAAAAAAAAAANDVKPPPP 932
                   |...:.|.|..:.|             ||....:.|.|.|.|           .|||.
Mosquito   850 TIHAKADPSTILGHHHPALQH-------------HQMPPPEFADLPQRA-----------PPPPK 890

  Fly   933 HICSNTGMQQQQQVGGGSGGALNNGGIE--GSKVTTDNLGNVTYSTSSK 979
            |:         :.|.|..||.|....::  ||     |.|.:|..:..|
Mosquito   891 HL---------KSVPGDGGGMLPAHALQLIGS-----NCGTLTKKSCVK 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	330/667 (49%)
Nlg3	XP_061500330.1	None