Protein Alignment Nlg4 and Ces1e

DIOPT Version :9

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_113753.2
• Gene: Ces1e / 29225
• RGDID: 621508
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 690
• Identity: 185/690 - (26%)
• Similarity: 275/690 - (39%)
• Gaps: 182/690 - (26%)

  Fly    40 GH----RIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRIS 100
            ||    .:|.|..|::.|..:.|:.  |.:.|.||||||:|.||....||:|.:...||..::.:
  Rat    18 GHPSSLPVVDTLQGKVLGKYVSLEG--FTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNT 80

  Fly   101 DKYSPVCPQR--LPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKK 163
            ..|.|:|.|.  ...|.|:      :...|.|.:.  |.|    ||||||||:::|.:. ....:
  Rat    81 TSYPPMCSQDPVAGQIVND------LLTNREENIS--LQF----SEDCLYLNIYTPADL-TKRDR 132

  Fly   164 LPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMD 228
            |||:|:|||........:.|||..|:::..||||.:.|||||.||.:....   |:| .|:|.:|
  Rat   133 LPVMVWIHGGGLVLGGASTYDGLALSTHENVVVVVIQYRLGIWGFFSTGDE---HSR-GNWGHLD 193

  Fly   229 QMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALV 293
            |:|||||:|.||..|||||.|||:.|...|...::.|:.|| :.:.|||:||..||.|.::..:.
  Rat   194 QVAALHWVQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSP-LAKNLFHKAISESGVALTAGLVK 257

  Fly   294 EDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTS----------F 348
            ::....|.|:|....|.     :.....:|.|||....|:|....::...|...          |
  Rat   258 KNTRPLAEKIAVVSGCK-----STTSAAMVHCLRQKTEEELLETTLKLNLFSLDLHGDSRQSYPF 317

  Fly   349 GPSV-DGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGG 412
            .|:| ||||             :.:......|:..|.:
  Rat   318 VPTVLDGVV-------------LPKMPEEILAEKDFNT--------------------------- 342

  Fly   413 YFGGSGAGTMNMGGHYDVLFGVVTGESIW------RFSAHDIQNGFEGERRDKIIRTYVRNAYNY 471
                           ...:.|:...|..|      .:...|:       :.|.:..|.:....::
  Rat   343 ---------------VPYIVGINKQEFGWILPTMMNYPPSDM-------KLDPMTATSLLKKSSF 385

  Fly   472 HLN---EIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSS 533
            .||   |.....|.:|.   |.:..|...:|..:..:.|..|..|.|
  Rat   386 LLNLPEEAIPVAVEKYL---RHTDDPDRNKDQLLELIGDVIFGVPSV------------------ 429

  Fly   534 TAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRM--GTV---HGEDLPYIFGAPLVD 593
                       ..|.|......|.|.|.|.|:.   .:..:|  .||   ||:::..:||||::.
  Rat   430 -----------IVSRGHRDAGARTYMYEFQYRP---SFSSKMKPSTVVGDHGDEIYSVFGAPILR 480

  Fly   594 GFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQ 658
            |      ..:|.|..||:.:|.||.||||.||||     ...||           .|..||   |
  Rat   481 G------GTSKEEINLSKMMMKFWANFARNGNPN-----GQGLP-----------HWPEYD---Q 520

  Fly   659 K--YLEIGMKPRIKNHFRAHQLSIWLRLI--PELHRAGME 694
            |  ||:||...:.....:..:::.|..|:  ..||....|
  Rat   521 KEGYLQIGATTQQAQKLKEKEVAFWSELLAMKPLHAGHTE 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	178/666 (27%)
Ces1e	NP_113753.2	COesterase	24..545	CDD:278561	178/667 (27%)
		Aes	43..>239	CDD:223730	84/213 (39%)
		Prevents secretion from ER (Potential)	558..561		1/3 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910