DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and CES4A

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	XP_011521323.1	Gene:	CES4A / 283848	HGNCID:	26741	Length:	628	Species:	Homo sapiens

Alignment Length:	749	Identity:	215/749 - (28%)
Similarity:	301/749 - (40%)	Gaps:	208/749 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLPTVLISWMH----------CAGASTADIYKGARLGHR-IVQTRYGRLHGLILPLDSFRFLRSV 67
            ||||....|..          |..|.||   .||....| .|.|:||.|.|..:.:..    ..:
Human    14 LLPTAGAGWSMRWILCWSLTLCLMAQTA---LGALHTKRPQVVTKYGTLQGKQMHVGK----TPI 71

  Fly    68 EVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSP--------------------------- 105
            :||||||::.||....||:|...|.||.|||.:..|.|
Human    72 QVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGWSLALSPGWSAVARSRLTATSASRVQ 136

  Fly   106 --VCPQRLP-----NIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKK 163
              :.||.|.     .:|.....|..|.....|..|.|     ..|||||||||::|..| ..:.:
Human   137 ASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWL-----RFSEDCLYLNVYAPARA-PGDPQ 195

  Fly   164 LPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLN-ANPNPHAHARVANYGLM 227
            |||:|:..|.:|...:.:.|:||.||:..:||:|.|.:||||.|||. ......:||| .|:||:
Human   196 LPVMVWFPGGAFIVGAASSYEGSDLAAREKVVLVFLQHRLGIFGFLRWRGRTDDSHAR-GNWGLL 259

  Fly   228 DQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWAL 292
            ||||||.|:|:||..|||||.:|||.|...||..|:.||.|| :..|||||||..||:|.....:
Human   260 DQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSP-LASGLFHRAISQSGTALFRLFI 323

  Fly   293 VEDPVLFAIKLAKEVNCTIPDDINRHHEQI-VDCLRDV----------PLEDLYLADIQAP-NFL 345
            ..:|:..|.|:|....|      |.:..|| |:|||.:          .:..|.|...:.| ..:
Human   324 TSNPLKVAKKVAHLAGC------NHNSTQILVNCLRALSGTKVMRVSNKMRFLQLNFQRDPEEII 382

  Fly   346 TSFGPSVDGVVIRPGHSNLDIDD--LMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSS 408
            .|..|.||||||.        ||  ::....:.||..
Human   383 WSMSPVVDGVVIP--------DDPLVLLTQGKVSSVP---------------------------- 411

  Fly   409 FGGGYFGGSGAGTMNMGGHYDVLFGV----VTGESIWR--FSAHDIQNGFEGERRDKIIRTYVRN 467
                |..|......|....|.:.|.:    :..|:|.:  :|...:.| ...|:...::..|:.|
Human   412 ----YLLGVNNLEFNWLLPYIMKFPLNRQAMRKETITKMLWSTRTLLN-ITKEQVPLVVEEYLDN 471

  Fly   468 AYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSS 532
                         |||: ||..       .|:..:..:.||.||...::....           .
Human   472 -------------VNEH-DWKM-------LRNRMMDIVQDATFVYATLQTAHY-----------H 504

  Fly   533 STAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDY--PQRMGTVHGEDLPYIFGAPLVDGF 595
            ..||.|                  .|.|.|::..: |..  |:..|..||:::.::||.|...|.
Human   505 RDAGLP------------------VYLYEFEHHAR-GIIVKPRTDGADHGDEMYFLFGGPFATGL 550

  Fly   596 SHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKY 660
            |      ...|.|||..:|.:|.|||||||||     |.:||           .|..|:. .:||
Human   551 S------MGKEKALSLQMMKYWANFARTGNPN-----DGNLP-----------CWPRYNK-DEKY 592

  Fly   661 LEIGMKPRIKNHFRAHQLSIWLRLI----PELHR 690
            |::....|:....:..:::.|:.|.    ||..|
Human   593 LQLDFTTRVGMKLKEKKMAFWMSLYQSQRPEKQR 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	198/694 (29%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	199/699 (28%)
CES4A	XP_011521323.1	Aes	<184..>291	CDD:223730	50/108 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810