Protein Alignment Nlg4 and Nlgn3

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_766520.2
• Gene: Nlgn3 / 245537
• MGIID: 2444609
• Length: 825
• Species: Mus musculus
• Alignment Length: 859
• Identity: 286/859 - (33%)
• Similarity: 399/859 - (46%)
• Gaps: 210/859 - (24%)

  Fly    44 VQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCP 108
            |.|.:|:|.|..:||.| ..|..|:.:||||||.||..:.||.|...|..|.|||.:..:.||||
Mouse    41 VNTHFGKLRGARVPLPS-EILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCP 104

  Fly   109 QRLPNIQNETAALEKM-PKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKK--------- 163
            |.:     .||..|.| |......|..:..:::..:||||||||:.|...|:..||
Mouse   105 QNI-----HTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDGSGAKKQGEDLADND 164

  Fly   164 ------------LPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPH 216
                        .||:|:|||.|:...:||..|||||||||.|:|:|||||:|:||||:...
Mouse   165 GDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYRVGVLGFLSTGD--- 226

  Fly   217 AHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAIL 281
             .|...||||:||:.||.|:.:||..|||||..:|:.|.|.||:|:: |:|......|||.|||:
Mouse   227 -QAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVS-LLTLSHHSEGLFQRAII 289

  Fly   282 MSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLT 346
            .||||.||||:...||.:...||.:|.|.:.|.::     :|||||....::|...|||...:..
Mouse   290 QSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVD-----MVDCLRQKSAKELVEQDIQPARYHV 349

  Fly   347 SFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGG 411
            :|||.:||.||..     |.:.||.:
Mouse   350 AFGPVIDGDVIPD-----DPEILMEQ--------------------------------------- 370

  Fly   412 GYFGGSGAGTMNMGGHYDVLFGVVTGESIWRF--SAHDIQNGFEGERRDKIIRTYVRNAYNY--- 471
            |.|       :|    ||::.||..||.: :|  ...|.::|..|...|..:..:|.|.|.|
Mouse   371 GEF-------LN----YDIMLGVNQGEGL-KFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEG 423

  Fly   472 --HLNEIFYTIVNEYTDW-DRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSS 533
              .|.|   ||...|||| ||  .:|...|.|.||..:|.|:|.|.|...|:.|
Mouse   424 KDTLRE---TIKFMYTDWADR--DNPETRRKTLVALFTDHQWVEPSVVTADLHA----------- 472

  Fly   534 TAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHF 598
            ..|||                  .|||.|.:..:....|......||:::||:||.|:|.....|
Mouse   473 RYGSP------------------TYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLF 519

  Fly   599 PQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEI 663
            |.|::|::..||..||.:|||||:||:||:...||:.. :..:.|||..:.|..|:|..|.||.|
Mouse   520 PCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKF-IHTKANRFEEVAWSKYNPRDQLYLHI 583

  Fly   664 GMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAG 728
            |:|||:::|:||.:::.|..|:|.|:..        |::|  |......:.| .||
Mouse   584 GLKPRVRDHYRATKVAFWKHLVPHLYNL--------HDMF--HYTSTTTKVP-PPD--------- 628

  Fly   729 ASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGG 793
                   ::.||.:                            |..||         |..:|:...
Mouse   629 -------TTHSSHI----------------------------TRRPN---------GKTWSTKRP 649

  Fly   794 VFAPTTLANASSDTLASGFEAAGYAA------YSTALSVTIAIGCSLLILNVLIFAGVYYQRDKT 852
            ..:| ..:|.::....:|.:.||...      |||.||||||:|.|||.||||.||.:||::||.
Mouse   650 AISP-AYSNENAPGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKR 713

  Fly   853 RLEVKTLQKQYQQR 866
            |.|  .|::...||
Mouse   714 RQE--PLRQPSPQR 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	236/666 (35%)
Nlgn3	NP_766520.2	COesterase	37..601	CDD:395084	236/666 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	151..172		2/20 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..668		13/100 (13%)