Protein Alignment Nlg4 and Ces1a

DIOPT Version :9

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_001013786.2
• Gene: Ces1a / 244595
• MGIID: 3648919
• Length: 563
• Species: Mus musculus
• Alignment Length: 689
• Identity: 180/689 - (26%)
• Similarity: 272/689 - (39%)
• Gaps: 200/689 - (29%)

  Fly    39 LGH----RIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRI 99
            |||    .:|.|..|::.|..:.|:.  ..:.|.||||||:|.||....||:|.:....|..::.
Mouse    17 LGHLSSPPVVDTLQGKVMGKYISLEG--SAQPVAVFLGVPFAKPPLGPLRFAPPQPAETWSSVKN 79

  Fly   100 SDKYSPVCPQRL---PNIQNE-TAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGAN 160
            :..|.|:|.|..   |.:.:. |..||.:|   |||           ||||||||::||.:. .:
Mouse    80 TTSYPPMCSQITGVGPVLSDVFTNQLENVP---LEY-----------SEDCLYLNIYSPTDL-TS 129

  Fly   161 EKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYG 225
            :.:|||:|::||........:.:||..|:::..||:|.:.|||||.|||:....   |:| .|:|
Mouse   130 KDRLPVMVWVHGGGLLSGGASTFDGLALSTHENVVIVVIQYRLGIWGFLSTGDE---HSR-GNWG 190

  Fly   226 LMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSW 290
            .:||:|||.|:|.||..|||||:||||.|...|...::.|:.|| :.:.||.|||..||.|.:
Mouse   191 HLDQVAALQWVQNNIANFGGDPSSVTLFGESAGGESVSVLVLSP-LTKNLFQRAISESGVALT-- 252

  Fly   291 ALVEDPVLF-------AIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDL---------YLADI 339
                 |.||       |.::|....|......:     ||.|||:...|:|         :..|:
Mouse   253 -----PCLFRETTRRAAEQVAIATGCVATTSAD-----IVHCLREKTEEELLATTLKMKFFALDL 307

  Fly   340 -----QAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGG 399
                 ::..|||:.   :||||:....     ::::|..|..:..
Mouse   308 LGDPRESYPFLTTV---IDGVVLPKAP-----EEILAEKSFNTVP-------------------- 344

  Fly   400 GGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGES----------IWRFSAHDIQNGFEG 454
                         |.  .|......|....::.|....|.          :|:
Mouse   345 -------------YI--VGINKQEFGWFIPMMMGYPLSEGKLDQKSATSLLWK------------ 382

  Fly   455 ERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTD-WDRTSQHPINTRDTAVAALSDAQFVAPIVRAG 518
                           :|.|..|...:....|: :...|..|...:|..:..:.|..|..|.|
Mouse   383 ---------------SYPLTNISKELTPVATEKYLGGSDCPDKKKDLFLDMMGDVLFAVPSV--- 429

  Fly   519 DILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTK--DGDYPQRMGTVHGE 581
             |:|       .....||:|                  .|.|.|.|...  ....|:.:...||:
Mouse   430 -IVA-------RYHRDAGAP------------------TYMYEFKYHPSFVSDMRPKTVIADHGD 468

  Fly   582 DLPYIFGAP-LVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRF 645
            ::..::|.| |.:|.|       :.|..||..:|.||.||||.||||     ...||
Mouse   469 EVYSVWGTPFLKEGAS-------EEEINLSTMMMKFWGNFARNGNPN-----GEGLP-------- 513

  Fly   646 RSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRL 684
               .|..|.. .:.||:||...:.....:..:::.|..|
Mouse   514 ---HWPEYGE-KESYLQIGATTQQAQRLKDKEVAFWTSL 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	175/676 (26%)
Ces1a	NP_001013786.2	Esterase_lipase	25..536	CDD:238191	175/667 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810