DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and Cel

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	205/745 - (27%)
Similarity:	293/745 - (39%)	Gaps:	239/745 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 CAGASTADIYKGARLGHRIVQTRYGRLHGL-----ILPLDSFRFLRSVEVFLGVPYATPPTKQNR 84
            |..|:.|     |:||  .|.|..|.:.|:     :|..|      ||::|.|:|:||..|.:|
  Rat    14 CLAAACA-----AKLG--AVYTEGGFVEGVNKKLSLLGGD------SVDIFKGIPFATAKTLEN- 64

  Fly    85 FSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYL 149
              |.|.|. |.|...:..:...|.|.... |::|..                      .||||||
  Rat    65 --PQRHPG-WQGTLKATDFKKRCLQATIT-QDDTYG----------------------QEDCLYL 103

  Fly   150 NVFSPVNAGANEKKLPVIVFIHGESFEWSSGNP--------YDGSVLASYGEVVVVTLNYRLGIL 206
            |::.|.........|||:|:|:|.:|...||..        |||..:|:.|.|:|||.|||:|.|
  Rat   104 NIWVPQGRKQVSHDLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPL 168

  Fly   207 GFL---NAN-PNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMT 267
            |||   :|| |        .|:||.||..|:.|:::||..|||||:::|:.|...|||.::....
  Rat   169 GFLSTGDANLP--------GNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTL 225

  Fly   268 SPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLE 332
            || ..:||..|||..||.|.|.||:.|:|:.:|..:||:|.|...|.     .::..||:.....
  Rat   226 SP-YNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGCPTEDT-----AKMAGCLKITDPR 284

  Fly   333 DLYLA--------DIQAPNFLTSFGPSVDGVVIRPGHSNL-----DIDDLMARNSRRSSADSGFQ 384
            .|.||        :....::| :|.|.|||..|.....||     |||.|
  Rat   285 ALTLAYRLPLKSQEYPIVHYL-AFIPVVDGDFIPDDPINLYDNAADIDYL--------------- 333

  Fly   385 SSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGV------------VTG 437
                                              ||..:|.||   ||..            ||.
  Rat   334 ----------------------------------AGINDMDGH---LFATVDVPAIDKAKQDVTE 361

  Fly   438 ESIWRF-SAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPI--NTRD 499
            |..:|. |.|.:..|.:|                   .:..:.|..|  .|   :|.|.  |.:.
  Rat   362 EDFYRLVSGHTVAKGLKG-------------------TQATFDIYTE--SW---AQDPSQENMKK 402

  Fly   500 TAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDY 564
            |.||..:|..|:.|...|   ||.:.              |:|          .|.:.|.|:|.:
  Rat   403 TVVAFETDILFLIPTEMA---LAQHR--------------AHA----------KSAKTYSYLFSH 440

  Fly   565 QTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEH 629
            .::...||:.||..|.:||.|:||.|...     |..|...:..:|:|::.:|||||::|:||
  Rat   441 PSRMPIYPKWMGADHADDLQYVFGKPFAT-----PLGYRAQDRTVSKAMIAYWTNFAKSGDPN-- 498

  Fly   630 HRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMK---PRIKNHFRAHQLSIW---LRLIPEL 688
             ..:|.:|..          |..|...:..||:|..|   ..:|.|.|...|..|   ..::|
  Rat   499 -MGNSPVPTH----------WYPYTTENGNYLDINKKITSTSMKEHLREKFLKFWAVTFEMLP-- 550

  Fly   689 HRAGMEDVIARHNLFRNHDDMDLYEGPVKP 718
                  .|:..|.  ...||.:  ..||.|
  Rat   551 ------TVVGDHT--PPEDDSE--AAPVPP 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	190/685 (28%)
Cel	NP_058693.2	COesterase	26..542	CDD:278561	190/684 (28%)
		Aes	<118..>247	CDD:223730	59/137 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612		6/22 (27%)
		4 X 11 AA tandem repeats, O-glycosylated region	556..599		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910