DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg4 and CES3

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_079198.2	Gene:	CES3 / 23491	HGNCID:	1865	Length:	571	Species:	Homo sapiens

Alignment Length:	728	Identity:	201/728 - (27%)
Similarity:	300/728 - (41%)	Gaps:	198/728 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ESQLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSV 67
            ||.:|:.:..|||.        |...:|     |..:....|.|..||:.|..:.:....  |.|
Human     8 ESGVLVGVVCLLLA--------CPATAT-----GPEVAQPEVDTTLGRVRGRQVGVKGTD--RLV 57

  Fly    68 EVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYL 132
            .||||:|:|.||...:|||......||:|:|.:....|:|.|.:.::.:....|    .|:.:
Human    58 NVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVL----NGKQQ-- 116

  Fly   133 KRLLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVV 197
                  :.:.|||||.|||:||....|...: ||:|::||.:....:...||||.||:||:||||
Human   117 ------IFSVSEDCLVLNVYSPAEVPAGSGR-PVMVWVHGGALITGAATSYDGSALAAYGDVVVV 174

  Fly   198 TLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACI 262
            |:.||||:|||.:.. :.||   ..|.|.:|.:|||.|:|:||..||||.|.||:.|...|.:.|
Human   175 TVQYRLGVLGFFSTG-DEHA---PGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSII 235

  Fly   263 NYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLR 327
            :.|:.|| :..|||||||..||...:...:...|...|.|:|..:.|:     :....::|.||:
Human   236 SGLVLSP-VAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACS-----SSSPAEMVQCLQ 294

  Fly   328 DVPLEDLYLADIQAPNFLTSFGPSVDGVVI----------RPGHSNLDIDDLMARNSRRSSADSG 382
            ....|:|.|:. :..|  |.:..:|||.|.          :|.||   :..||..|:...|
Human   295 QKEGEELVLSK-KLKN--TIYPLTVDGTVFPKSPKELLKEKPFHS---VPFLMGVNNHEFS---- 349

  Fly   383 FQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAG---TMNMGGHYDVLFGVVTGESIWRFS 444
                                          :....|.|   ||......|:|
Human   350 ------------------------------WLIPRGWGLLDTMEQMSREDML------------- 371

  Fly   445 AHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQ 509
                           .|.|.|..:.:.. .|:..|:::||                 :.:.||||
Human   372 ---------------AISTPVLTSLDVP-PEMMPTVIDEY-----------------LGSNSDAQ 403

  Fly   510 FVAPIVR--AGDILAANSPPPVSSS---STAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDG 569
            ......:  .||:..  :.|.||.|   ..:|||                  .:||  ::|.:..
Human   404 AKCQAFQEFMGDVFI--NVPTVSFSRYLRDSGSP------------------VFFY--EFQHRPS 446

  Fly   570 DY----PQRMGTVHGEDLPYIFGAP-LVDGFSH--FPQNYTKSETALSEAVMIFWTNFARTGNPN 627
            .:    |..:...||.:..::||.| |:|..|.  ||: .|:.|..||..:|..||:|||||:||
Human   447 SFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPE-ATEEEKQLSLTMMAQWTHFARTGDPN 510

  Fly   628 EHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIP------ 686
                 ..:||           .|..::...| ||||...||....||...:..|...:|
Human   511 -----SKALP-----------PWPQFNQAEQ-YLEINPVPRAGQKFREAWMQFWSETLPSKIQQW 558

  Fly   687 ---ELHRAGMEDV 696
               :.:|...||:
Human   559 HQKQKNRKAQEDL 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	187/662 (28%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	187/665 (28%)
		Aes	<129..>247	CDD:223730	54/123 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810