Protein Alignment Nlg4 and Ces4a

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_666325.2
• Gene: Ces4a / 234677
• MGIID: 2384581
• Length: 563
• Species: Mus musculus
• Alignment Length: 681
• Identity: 194/681 - (28%)
• Similarity: 287/681 - (42%)
• Gaps: 183/681 - (26%)

  Fly    43 IVQTRYGRL----------HGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGI 97
            :|||..|.|          ||::...........::||||:|::.||....||:|...|.||:||
Mouse    21 VVQTALGALHTKEPLLITKHGILQGKQVHVGDTPIQVFLGIPFSKPPVGTRRFAPPEPPLPWNGI 85

  Fly    98 RISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNA-GANE 161
            |.:..|.|.|.|     ::....|......|.:|  :.|.|    |||||||||::||.| ||
Mouse    86 RDATTYPPSCLQ-----ESWGQILSMYLNTRKQY--KWLHF----SEDCLYLNVYAPVLAPGA-- 137

  Fly   162 KKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGL 226
            ..|||:|:..|.:|...|.:.|:||.||:.|:||:|.|.||||||||.:..   ::||| .|:||
Mouse   138 PLLPVMVWFPGGAFLAGSASTYEGSELAARGKVVLVFLQYRLGILGFFSTG---NSHAR-GNWGL 198

  Fly   227 MDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWA 291
            :||:|||.|:|:||:.|||||:||||.|...||..::.||.|| :.:||||:||..||:|.....
Mouse   199 LDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLMVSP-LAQGLFHQAISQSGTAVLKAF 262

  Fly   292 LVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLAD-----IQA-----PNFLT 346
            :..||:..|.|:|....|.     :...:.:|:|||.:..|::.|..     .||     |..:.
Mouse   263 ITPDPLTSAKKIAHLAGCD-----HNSTKVMVECLRSLSAEEVTLVSKRMSFFQANSHKDPKEIV 322

  Fly   347 SF-GPSVDGVV-------------IRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGA 397
            .| .|.|||||             ::|      :..|:..|:.....:..|
Mouse   323 WFLSPVVDGVVFPEDPVVLLTRGQVKP------VPYLLGVNNAEFEWNLPF-------------- 367

  Fly   398 GGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIR 462
                                   .|.:..:..::......:.:|.|   ::......|:...:.|
Mouse   368 -----------------------LMKIQLNQRMMNQTNINKILWSF---NVLLNITKEQVPVVAR 406

  Fly   463 TYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPP 527
            .|:.:|.:.|             ||..       .|:..:..:.||.||...::|
Mouse   407 EYLNDAISNH-------------DWKM-------FRNRLIDLIGDATFVYATLQA---------- 441

  Fly   528 PVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDG----DYPQRMGTVHGEDLPYIFG 588
             ......||||                  .|.|.|.:....|    .|   .|..||::|.|:||
Mouse   442 -ARYHRDAGSP------------------VYLYEFKHHASSGIIIKPY---NGADHGDELSYLFG 484

  Fly   589 APLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENY 653
            :|...|.|      ...|...|..:|.:|.|||.|||||     ...||.           |..:
Mouse   485 SPFSKGSS------AGEEKEFSLQMMKYWANFAHTGNPN-----GEKLPY-----------WPRF 527

  Fly   654 DPLHQKYLEIGMKPRIKNHFRAHQLSIWLRL 684
            |. .:|||::....|:....:..:::.|.:|
Mouse   528 DK-DEKYLQLDFDTRVGVKLKEKKMAFWSQL 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	192/676 (28%)
Ces4a	NP_666325.2	COesterase	33..554	CDD:395084	187/664 (28%)