Protein Alignment Nlg4 and Ces2e

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_766347.1
• Gene: Ces2e / 234673
• MGIID: 2443170
• Length: 559
• Species: Mus musculus
• Alignment Length: 682
• Identity: 181/682 - (26%)
• Similarity: 281/682 - (41%)
• Gaps: 166/682 - (24%)

  Fly    18 VLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQ 82
            ||:..:|..|..:|.         .|..|..|::.|.::.:.....  :|..|||:|:|.||...
Mouse    17 VLLLVLHVQGQDSAS---------PIRNTHTGQVRGSLVHVKDTDI--AVHTFLGIPFAKPPVGP 70

  Fly    83 NRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCL 147
            .||:|..||.||.|:|....:..:|      :||:..    |....|:.:..:||.: :.|||||
Mouse    71 LRFAPPEAPEPWSGVRDGTSHPNMC------LQNDNL----MGSEDLKMMNLILPPI-SMSEDCL 124

  Fly   148 YLNVFSPVNA--GANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLN 210
            |||::.|.:|  |:|   |||:|:|||.:......:.||||:||:..:||||.:.||||:|||.:
Mouse   125 YLNIYVPAHAHEGSN---LPVMVWIHGGALTVGMASMYDGSMLAATEDVVVVAIQYRLGVLGFFS 186

  Fly   211 ANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGL 275
            ....   ||: .|:|.:||:|||.|:||||..|||:|:.||:.|...|...::..:.|| |.:||
Mouse   187 TGDQ---HAK-GNWGYLDQVAALRWVQQNIVHFGGNPDRVTIFGESAGGTSVSSHVVSP-MSQGL 246

  Fly   276 FHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQ 340
            ||.||:.||.     |::.|.:..:.::...:...:......:.|.::.|||     ....|::.
Mouse   247 FHGAIMESGV-----AVLPDLISSSSEMVHRIVANLSGCAAVNSETLMCCLR-----GKNEAEML 301

  Fly   341 APNFLTSFGPS-VDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGG 404
            |.|.:....|. |||..: |.|.    .:|||      |.|.....|
Mouse   302 AINKVFKIIPGVVDGEFL-PKHP----QELMA------SKDFHPVPS------------------ 337

  Fly   405 SGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRF-SAHDIQNGFEGERRDKIIRTYVRNA 468
                                      :.|:...|..|.. :..|.....|...|..:.......|
Mouse   338 --------------------------IIGINNDEYGWILPTIMDPAQKIEEITRKTLPAVLKSTA 376

  Fly   469 YNYHL-NEIFYTIVNEY---TDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPV 529
            ....| .|....::.||   |:...|.|.......      .|..||.|.::......:::|
Mouse   377 LKMMLPPECGDLLMEEYMGDTEDPETLQAQFREMK------GDFMFVIPALQVAHFQRSHAP--- 432

  Fly   530 SSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQT---KDGDYPQRMGTVHGEDLPYIFGAPL 591
                                       .|||.|.::.   || ..|..:...||:::..:||..
Mouse   433 ---------------------------VYFYEFQHRPSFFKD-FRPPYVKADHGDEIFLVFGYQ- 468

  Fly   592 VDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPL 656
               |.:....||:.|..||..:|.:|.||||.||||     ...||.           |...|
Mouse   469 ---FGNIKLPYTEEEEQLSRRIMKYWANFARHGNPN-----SEGLPY-----------WPVMD-- 512

  Fly   657 H-QKYLEIGMKPRIKNHFRAHQLSIWLRLIPE 687
            | ::||::.::|.:....:|.:|..|.:.:|:
Mouse   513 HDEQYLQLDIQPSVGRALKARRLQFWTKTLPQ 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	174/649 (27%)
Ces2e	NP_766347.1	COesterase	30..538	CDD:395084	175/661 (26%)