Protein Alignment Nlg4 and Ces2c

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_663578.1
• Gene: Ces2c / 234671
• MGIID: 2385905
• Length: 561
• Species: Mus musculus
• Alignment Length: 700
• Identity: 184/700 - (26%)
• Similarity: 292/700 - (41%)
• Gaps: 188/700 - (26%)

  Fly     6 LLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVF 70
            |||||            :|..|..:.:       .:.|..|..|::.|.::.:...:  ..|..|
Mouse    17 LLLLL------------IHVQGQDSPE-------ANPIRNTHTGQIQGSLIHVKDTK--AGVHTF 60

  Fly    71 LGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRL 135
            ||:|:|.||....||:|..||.||.|:|....:..:|      :||    |:.:.:..|..:|.:
Mouse    61 LGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMC------LQN----LDMLNEAGLPDMKMM 115

  Fly   136 LPFLENQSEDCLYLNVFSPVNA--GANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVT 198
            |.... .||||||||:::|.:|  |:|   |||:|:|||.:......:.:|||:|....::||||
Mouse   116 LSSFP-MSEDCLYLNIYTPAHAHEGSN---LPVMVWIHGGALVIGMASMFDGSLLTVNEDLVVVT 176

  Fly   199 LNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACIN 263
            :.||||:|||.:....   ||| .|:|.:||.|||.|:||||..|||:|:.||:.|...|...::
Mouse   177 IQYRLGVLGFFSTGDQ---HAR-GNWGYLDQAAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVS 237

  Fly   264 YLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRD 328
            ..:.|| |.:||||.||:.||.|.....:.|...:.:..:||...|...|.     :.:|.|||.
Mouse   238 SHVVSP-MSQGLFHGAIMESGVALLPDLISETSEMVSTTVAKLSGCEAMDS-----QALVRCLRG 296

  Fly   329 VPLEDLYLADIQAPNFLTSFGPS-VDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQ---SSAGG 389
            ..     .|:|.|.|.:....|: |||             :...|:.:...|...|.   |..|.
Mouse   297 KS-----EAEILAINKVFKMIPAVVDG-------------EFFPRHPKELLASEDFHPVPSIIGV 343

  Fly   390 GGGQGGGAGGGGGGGSGSSFGGGYFGGS-----GAGTMNMGGHYDVLFGVVTGE---SIWRFSAH 446
            ...:                    ||.|     |:..|..|         :|.|   ::.:.:|
Mouse   344 NNDE--------------------FGWSIPVVMGSAQMIKG---------ITRENLQAVLKDTA- 378

  Fly   447 DIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFV 511
             :|.....|..|.::..|:.:      .|...|:..::|:                 .:.|..||
Mouse   379 -VQMMLPPECSDLLMEEYMGD------TEDAQTLQIQFTE-----------------MMGDFMFV 419

  Fly   512 APIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQT---KDGDYPQ 573
            .|.::......:::|                              .|||.|.:..   || ..|.
Mouse   420 IPALQVAHFQRSHAP------------------------------VYFYEFQHPPSYFKD-VRPP 453

  Fly   574 RMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPV 638
            .:...|.:::|::|.:    .|.....::|:.|..||..:|.:|.||||.||||     ...||.
Mouse   454 HVKADHADEIPFVFAS----FFWGMKLDFTEEEELLSRRMMKYWANFARHGNPN-----SEGLPY 509

  Fly   639 SKERNRFRSITWENYDPLH-QKYLEIGMKPRIKNHFRAHQLSIWLRLIPE 687
                       |...|  | ::||::.::|.:....:|.:|..|.:.:|:
Mouse   510 -----------WPVMD--HDEQYLQLDIQPAVGRALKAGRLQFWTKTLPQ 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	175/655 (27%)
Ces2c	NP_663578.1	COesterase	32..540	CDD:395084	175/658 (27%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561