DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and Ces2c

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_663578.1	Gene:	Ces2c / 234671	MGIID:	2385905	Length:	561	Species:	Mus musculus

Alignment Length:	700	Identity:	184/700 - (26%)
Similarity:	292/700 - (41%)	Gaps:	188/700 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVF 70
            |||||            :|..|..:.:       .:.|..|..|::.|.::.:...:  ..|..|
Mouse    17 LLLLL------------IHVQGQDSPE-------ANPIRNTHTGQIQGSLIHVKDTK--AGVHTF 60

  Fly    71 LGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRL 135
            ||:|:|.||....||:|..||.||.|:|....:..:|      :||    |:.:.:..|..:|.:
Mouse    61 LGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMC------LQN----LDMLNEAGLPDMKMM 115

  Fly   136 LPFLENQSEDCLYLNVFSPVNA--GANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVT 198
            |.... .||||||||:::|.:|  |:|   |||:|:|||.:......:.:|||:|....::||||
Mouse   116 LSSFP-MSEDCLYLNIYTPAHAHEGSN---LPVMVWIHGGALVIGMASMFDGSLLTVNEDLVVVT 176

  Fly   199 LNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACIN 263
            :.||||:|||.:....   ||| .|:|.:||.|||.|:||||..|||:|:.||:.|...|...::
Mouse   177 IQYRLGVLGFFSTGDQ---HAR-GNWGYLDQAAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVS 237

  Fly   264 YLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRD 328
            ..:.|| |.:||||.||:.||.|.....:.|...:.:..:||...|...|.     :.:|.|||.
Mouse   238 SHVVSP-MSQGLFHGAIMESGVALLPDLISETSEMVSTTVAKLSGCEAMDS-----QALVRCLRG 296

  Fly   329 VPLEDLYLADIQAPNFLTSFGPS-VDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQ---SSAGG 389
            ..     .|:|.|.|.:....|: |||             :...|:.:...|...|.   |..|.
Mouse   297 KS-----EAEILAINKVFKMIPAVVDG-------------EFFPRHPKELLASEDFHPVPSIIGV 343

  Fly   390 GGGQGGGAGGGGGGGSGSSFGGGYFGGS-----GAGTMNMGGHYDVLFGVVTGE---SIWRFSAH 446
            ...:                    ||.|     |:..|..|         :|.|   ::.:.:|
Mouse   344 NNDE--------------------FGWSIPVVMGSAQMIKG---------ITRENLQAVLKDTA- 378

  Fly   447 DIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFV 511
             :|.....|..|.::..|:.:      .|...|:..::|:                 .:.|..||
Mouse   379 -VQMMLPPECSDLLMEEYMGD------TEDAQTLQIQFTE-----------------MMGDFMFV 419

  Fly   512 APIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQT---KDGDYPQ 573
            .|.::......:::|                              .|||.|.:..   || ..|.
Mouse   420 IPALQVAHFQRSHAP------------------------------VYFYEFQHPPSYFKD-VRPP 453

  Fly   574 RMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPV 638
            .:...|.:::|::|.:    .|.....::|:.|..||..:|.:|.||||.||||     ...||.
Mouse   454 HVKADHADEIPFVFAS----FFWGMKLDFTEEEELLSRRMMKYWANFARHGNPN-----SEGLPY 509

  Fly   639 SKERNRFRSITWENYDPLH-QKYLEIGMKPRIKNHFRAHQLSIWLRLIPE 687
                       |...|  | ::||::.::|.:....:|.:|..|.:.:|:
Mouse   510 -----------WPVMD--HDEQYLQLDIQPAVGRALKAGRLQFWTKTLPQ 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	175/655 (27%)
Ces2c	NP_663578.1	COesterase	31..540	CDD:278561	175/666 (26%)
		Aes	<130..>233	CDD:223730	48/109 (44%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810