DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and NLGN1

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_001352852.1	Gene:	NLGN1 / 22871	HGNCID:	14291	Length:	843	Species:	Homo sapiens

Alignment Length:	987	Identity:	297/987 - (30%)
Similarity:	429/987 - (43%)	Gaps:	288/987 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVC 107
            :|.|.:|::.|:...|:: ..|..|..|||||||.|||.:.||.|...|:||..||.:.:::|||
Human    54 LVATNFGKIRGIKKELNN-EILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVC 117

  Fly   108 PQ-----RLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPV------------ 155
            ||     |||.:.        :|......|..:..::::|||||||||::.|.
Human   118 PQNIIDGRLPEVM--------LPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDD 174

  Fly   156 ---NAGANEKKL-------PVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLN 210
               |.||.::.:       ||:|:|||.|:...:||.||||||||||.|:|:|:|||||:||||:
Human   175 LGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYGNVIVITVNYRLGVLGFLS 239

  Fly   211 ANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTS------- 268
            ...    .|...||||:|.:.||.|..:||..|||||..:|:.|.|.|.:|:|.|..|
Human   240 TGD----QAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNR 300

  Fly   269 -PTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLE 332
             ....:|||.|||..||:|.||||:...|..:|..||.:|.|.:.|.:     ::|:||:..|.:
Human   301 WSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARMLATKVGCNVSDTV-----ELVECLQKKPYK 360

  Fly   333 DLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDD---LMARNSRRSSADSGFQSSAGGGGGQG 394
            :|...|||...:..:|||.:||.||.        ||   ||.:
Human   361 ELVDQDIQPARYHIAFGPVIDGDVIP--------DDPQILMEQ---------------------- 395

  Fly   395 GGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAH--DIQNGFEGERR 457
                             |.|       :|    ||::.||..||.: :|..:  |..:|......
Human   396 -----------------GEF-------LN----YDIMLGVNQGEGL-KFVENIVDSDDGISASDF 431

  Fly   458 DKIIRTYVRNAYNYH-----LNEIFYTIVNEYTDW-DRTSQHPINTRDTAVAALSDAQFVAPIVR 516
            |..:..:|.|.|.|.     |.|   ||...|||| ||  .:|...|.|.:|..:|.|:|||.|.
Human   432 DFAVSNFVDNLYGYPEGKDVLRE---TIKFMYTDWADR--HNPETRRKTLLALFTDHQWVAPAVA 491

  Fly   517 AGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGE 581
            ..|:           .|..|||                  .|||.|.:..:....|......||:
Human   492 TADL-----------HSNFGSP------------------TYFYAFYHHCQTDQVPAWADAAHGD 527

  Fly   582 DLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFR 646
            ::||:.|.|::.....||.|::|::..||..||.:|||||:||:||:...||:.. :..:.|||.
Human   528 EVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF-IHTKPNRFE 591

  Fly   647 SITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDL 711
            .:.|..|....|.||.||:|||:|.|:||:::::||.|:|.||               |.:|:..
Human   592 EVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLH---------------NLNDISQ 641

  Fly   712 YEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEPNN 776
            |          .||
Human   642 Y----------TST--------------------------------------------------- 645

  Fly   777 MYTTCIPIGGNYSSSGGVFAPTTLANASSDTLASGFEAA--------------GYAAYSTALSVT 827
              ||.:|      |:...|.||   ..:|..:.|.|..|              ....|||.||||
Human   646 --TTKVP------STDITFRPT---RKNSVPVTSAFPTAKQDDPKQQPSPFSVDQRDYSTELSVT 699

  Fly   828 IAIGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQRSLHQQVPYPPE----PIKHAHYHMGH 888
            ||:|.|||.||:|.||.:||::||.|.:|.  ::...||:....:.:..|    .::..|..:.|
Human   700 IAVGASLLFLNILAFAALYYKKDKRRHDVH--RRCSPQRTTTNDLTHAQEEEIMSLQMKHTDLDH 762

  Fly   889 SQSSANVIVDVESHQDQAGQAAMLLQAA-----AAAAAAAANDVKPPPPH---ICSNT--GMQQQ 943
            ...|      :..|:       ::|:.|     ..|...:.:||....|:   :..||  |:|..
Human   763 ECES------IHPHE-------VVLRTACPPDYTLAMRRSPDDVPLMTPNTITMIPNTIPGIQPL 814

  Fly   944 QQVGGGSGGALN 955
            ......:||..|
Human   815 HTFNTFTGGQNN 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	231/683 (34%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	231/683 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1598
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.830