DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and NLGN4Y

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_001352513.1	Gene:	NLGN4Y / 22829	HGNCID:	15529	Length:	836	Species:	Homo sapiens

Alignment Length:	1023	Identity:	307/1023 - (30%)
Similarity:	441/1023 - (43%)	Gaps:	292/1023 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGESQLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLR 65
            |..|.:||.:..|.:...||.               ::..:.:|.|.||::.||..||.| ..|.
Human    20 MLNSNVLLWITALAIKFTLID---------------SQAQYPVVNTNYGKIQGLRTPLPS-EILG 68

  Fly    66 SVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKM-PKGRL 129
            .||.:||||||:|||.:.||.|..:|:.|.|||.:.::|.||||.|    :|...|..| |....
Human    69 PVEQYLGVPYASPPTGERRFQPPESPSSWTGIRNATQFSAVCPQHL----DERFLLHDMLPIWFT 129

  Fly   130 EYLKRLLPFLENQSEDCLYLNVFSPVNAGANEK----------------------KLPVIVFIHG 172
            ..|..|:.::::|:|||||||::.|:..|.|.|                      |.||:|:|||
Human   130 TSLDTLMTYVQDQNEDCLYLNIYVPMEDGTNIKRNADDITSNDHGEDKDIHEQNSKKPVMVYIHG 194

  Fly   173 ESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQ 237
            .|:...:||..|||:|||||.|:|:|:||||||||||:...    .|...||||:||:.||.||:
Human   195 GSYMEGTGNMIDGSILASYGNVIVITINYRLGILGFLSTGD----QAAKGNYGLLDQIQALRWIE 255

  Fly   238 QNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIK 302
            :|:..|||||..||:.|.|.||:|:: |:|......|||.:||:.||:|.||||:...|..:...
Human   256 ENVGAFGGDPKRVTIFGSGAGASCVS-LLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRI 319

  Fly   303 LAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDID 367
            ||.:|.|.:.|..:     :|:||::...::|....|....:..:|||.:||.||.        |
Human   320 LADKVGCNMLDTTD-----MVECLKNKNYKELIQQTITPATYHIAFGPVIDGDVIP--------D 371

  Fly   368 D---LMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYD 429
            |   ||.:                                       |.|       :|    ||
Human   372 DPQILMEQ---------------------------------------GEF-------LN----YD 386

  Fly   430 VLFGVVTGESIWRF--SAHDIQNGFEGERRDKIIRTYVRNAYNY-----HLNEIFYTIVNEYTDW 487
            ::.||..||.: :|  ...|.::|......|..:..:|.|.|.|     .|.|   ||...||||
Human   387 IMLGVNQGEGL-KFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDW 447

  Fly   488 DRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQ 552
             ...::|...|.|.||..:|.|:|||.|...|:.|           ..|||
Human   448 -ADKENPETRRKTLVALFTDHQWVAPAVATADLHA-----------QYGSP-------------- 486

  Fly   553 PSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFW 617
                .|||.|.:..:....|....:.||:::||:||.|::.....|..|::|::..||..||.:|
Human   487 ----TYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTELFSCNFSKNDVMLSAVVMTYW 547

  Fly   618 TNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWL 682
            ||||:||:||:...||:.. :..:.|||..:.|..|:|..|.||.||:|||:::|:||.:::.||
Human   548 TNFAKTGDPNQPVPQDTKF-IHTKPNRFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFWL 611

  Fly   683 RLIPELHRAGMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDE 747
            .|:|.||               |.:::..|          :||
Human   612 ELVPHLH---------------NLNEIFQY----------VST---------------------- 629

  Fly   748 QLMMKKGRGLNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGGVFAPTTLANA--------- 803
                                 .|.|.|.:|  |..|.|...|.:  ...|||...|
Human   630 ---------------------TTKVPPPDM--TSFPYGTRRSPA--KIWPTTKRPAITPANNPKH 669

  Fly   804 SSDTLASGFEAAGYAA-----YSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQY 863
            |.|...:|.|......     |||.||||||:|.|||.||:|.||.:||::||.|.|
Human   670 SKDPHKTGPEDTTVLIETKRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHE-------- 726

  Fly   864 QQRSLHQQVPYPPEPIKHAHYHMGHSQSSANVIVDVESHQDQAGQAAMLLQAAAAAAAAAANDVK 928
                              .|.|....:::.|.|..:::.:..:.|...|.......:..|.:.::
Human   727 ------------------THRHPSPQRNTTNDITHIQNEEIMSLQMKQLEHDHECESLQAHDTLR 773

  Fly   929 ---PPP------------PHICSNT---------GMQQQQQVGGGSGG 952
               ||.            |.:..||         |||........|||
Human   774 LTCPPDYTLTLRRSPDDIPFMTPNTITMIPNTLMGMQPLHTFKTFSGG 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	232/670 (35%)
NLGN4Y	NP_001352513.1	COesterase	46..610	CDD:306613	232/671 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	454	1.000	Inparanoid score	I1598
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.930