DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and Nlgn2

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_001351066.1	Gene:	Nlgn2 / 216856	MGIID:	2681835	Length:	836	Species:	Mus musculus

Alignment Length:	844	Identity:	271/844 - (32%)
Similarity:	386/844 - (45%)	Gaps:	206/844 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVC 107
            :|.|.|||:.|:...|:: ..|..|..||||||||||....||.|..|||.|.|:|.:....|.|
Mouse    43 VVNTAYGRVRGVRRELNN-EILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPAC 106

  Fly   108 PQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEK---------- 162
            ||   |:.....|: .:|....:.|:....:::||||||||||::.|...|...|
Mouse   107 PQ---NLHGALPAI-MLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPP 167

  Fly   163 --------KLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHA 219
                    |.||::|:||.|:...:||.:||||||:||.|:|||||||||:||||:...    .|
Mouse   168 DTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVVTLNYRLGVLGFLSTGD----QA 228

  Fly   220 RVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSG 284
            ...||||:||:.||.|:.:||..|||||..:|:.|.|.||:|:|.|:.|... .|||.:||..||
Mouse   229 AKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHS-EGLFQKAIAQSG 292

  Fly   285 SAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFG 349
            :|.|||::...|:.:...||.:|.|...|.     .:.|:|||.....:|...|:|...:..:||
Mouse   293 TAISSWSVNYQPLKYTRLLAAKVGCDREDS-----TEAVECLRRKSSRELVDQDVQPARYHIAFG 352

  Fly   350 PSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYF 414
            |.|||.|:..     |.:.||.:                                       |.|
Mouse   353 PVVDGDVVPD-----DPEILMQQ---------------------------------------GEF 373

  Fly   415 GGSGAGTMNMGGHYDVLFGVVTGESIWRF--SAHDIQNGFEGERRDKIIRTYVRNAYNYH----- 472
                   :|    ||:|.||..||.: :|  .:.:.::|......|..:..:|.|.|.|.
Mouse   374 -------LN----YDMLIGVNQGEGL-KFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDV 426

  Fly   473 LNEIFYTIVNEYTDW-DRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAG 536
            |.|   ||...|||| ||.:..  ..|.|.:|..:|.|:|||.|
Mouse   427 LRE---TIKFMYTDWADRDNGE--MRRKTLLALFTDHQWVAPAV--------------------- 465

  Fly   537 SPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQN 601
                 |.|...|....|   .|||.|.:..:....|:.....||::|||:||.|:|.....||.|
Mouse   466 -----ATAKLHADYQSP---VYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCN 522

  Fly   602 YTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMK 666
            ::|::..||..||.:|||||:||:||:...||:.. :..:.|||..:.|..::...::||.||:|
Mouse   523 FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF-IHTKPNRFEEVVWSKFNSKEKQYLHIGLK 586

  Fly   667 PRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDLYE---GPVKPDPFGISTAAG 728
            ||:::::||::::.||.|:|.||....|       ||.....:..|.   .|..|.|       |
Mouse   587 PRVRDNYRANKVAFWLELVPHLHNLHTE-------LFTTTTRLPPYATRWPPRTPGP-------G 637

  Fly   729 ASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGG 793
            .||:......:                               |:.|.    :.|.:|
Mouse   638 TSGTRRPPPPA-------------------------------TLPPE----SDIDLG-------- 659

  Fly   794 VFAPTTLANASSDTLASGFEAAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVK 857
               |........|:          ..|||.||||:|:|.|||.||:|.||.:||:||: |.|::
Mouse   660 ---PRAYDRFPGDS----------RDYSTELSVTVAVGASLLFLNILAFAALYYKRDR-RQELR 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	226/663 (34%)
Nlgn2	NP_001351066.1	COesterase	42..601	CDD:306613	226/663 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..661		11/90 (12%)
		Required for interaction with LHFPL4. /evidence=ECO:0000269\|PubMed:28279354	679..699		12/19 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..836
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1619
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.920