Protein Alignment Nlg4 and Nlgn1

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_006535478.1
• Gene: Nlgn1 / 192167
• MGIID: 2179435
• Length: 863
• Species: Mus musculus
• Alignment Length: 998
• Identity: 295/998 - (29%)
• Similarity: 435/998 - (43%)
• Gaps: 290/998 - (29%)

  Fly    43 IVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVC 107
            :|.|.:|::.|:...|:: ..|..|..|||||||.|||.::||.|...|:||..||.:.:::|||
Mouse    54 LVTTNFGKIRGIKKELNN-EILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVC 117

  Fly   108 PQ-----RLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPV------------ 155
            ||     |||.:.        :|......|..:..::::|||||||||::.|.
Mouse   118 PQNIIDGRLPEVM--------LPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECAR 174

  Fly   156 -----------------------NAGANEKKL-------PVIVFIHGESFEWSSGNPYDGSVLAS 190
                                   |.||.::.:       ||:|:|||.|:...:||.||||||||
Mouse   175 KPGKKICRKGGPLTKKHTDDLGDNDGAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLAS 239

  Fly   191 YGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGH 255
            ||.|:|:|:|||||:||||:...    .|...||||:|.:.||.|..:||..|||||..:|:.|.
Mouse   240 YGNVIVITVNYRLGVLGFLSTGD----QAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGS 300

  Fly   256 GTGAACINYLMTS--------PTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIP 312
            |.|.:|:|.|..|        ....:|||.|||..||:|.||||:...|..:|..||.:|.|.:.
Mouse   301 GAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARILATKVGCNVS 365

  Fly   313 DDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDD---LMARNS 374
            |.:     ::|:||:..|.::|...|:|...:..:|||.:||.||.        ||   ||.:
Mouse   366 DTV-----ELVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVIP--------DDPQILMEQ-- 415

  Fly   375 RRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGES 439
                                                 |.|       :|    ||::.||..||.
Mouse   416 -------------------------------------GEF-------LN----YDIMLGVNQGEG 432

  Fly   440 IWRFSAH--DIQNGFEGERRDKIIRTYVRNAYNYH-----LNEIFYTIVNEYTDW-DRTSQHPIN 496
            : :|..:  |..:|......|..:..:|.|.|.|.     |.|   ||...|||| ||  .:|..
Mouse   433 L-KFVENIVDSDDGVSASDFDFAVSNFVDNLYGYPEGKDVLRE---TIKFMYTDWADR--HNPET 491

  Fly   497 TRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYV 561
            .|.|.:|..:|.|:|||.|...|:           .|..|||                  .|||.
Mouse   492 RRKTLLALFTDHQWVAPAVATADL-----------HSNFGSP------------------TYFYA 527

  Fly   562 FDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNP 626
            |.:..:....|......||:::||:.|.|::.....||.|::|::..||..||.:|||||:||:|
Mouse   528 FYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDP 592

  Fly   627 NEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRA 691
            |:...||:.. :..:.|||..:.|..|....|.||.||:|||:|.|:||:::::||.|:|.||
Mouse   593 NQPVPQDTKF-IHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLH-- 654

  Fly   692 GMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRG 756
                         |.:|:..|                       :|:::::...|
Mouse   655 -------------NLNDISQY-----------------------TSTTTKVPSTD---------- 673

  Fly   757 LNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGGVFAPTTLA--NASSD---TLASGFEAAG 816
                         .|:.|....:|                |.|.|  .|..|   ...|.| :..
Mouse   674 -------------ITLRPTRKNST----------------PVTSAFPTAKQDDPKQQPSPF-SVD 708

  Fly   817 YAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQRSLHQQVPYPPE---- 877
            ...|||.||||||:|.|||.||:|.||.:||::||.|.:|.  ::...||:....:.:.||
Mouse   709 QRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVH--RRCSPQRTTTNDLTHAPEEEIM 771

  Fly   878 PIKHAHYHMGHSQSSANVIVDVESHQDQAGQAAMLLQAA-----AAAAAAAANDVKPPPPH---I 934
            .::..|..:.|...|      :..|:       ::|:.|     ..|...:.:|:....|:   :
Mouse   772 SLQMKHTDLDHECES------IHPHE-------VVLRTACPPDYTLAMRRSPDDIPLMTPNTITM 823

  Fly   935 CSNT--GMQQQQQVGGGSGGALN 955
            ..||  |:|........:||..|
Mouse   824 IPNTIPGIQPLHTFNTFTGGQNN 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	230/703 (33%)
Nlgn1	XP_006535478.1	COesterase	52..646	CDD:395084	230/703 (33%)