DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg4 and cest-31

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_504692.3	Gene:	cest-31 / 187304	WormBaseID:	WBGene00019653	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	609	Identity:	165/609 - (27%)
Similarity:	238/609 - (39%)	Gaps:	171/609 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 VEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEY 131
            |..:||:|||.||....||....:...|...|...||.|.||                |.|.| |
Worm    36 VHGYLGIPYAQPPIGILRFKKPVSADVWTETRDCTKYGPRCP----------------PSGML-Y 83

  Fly   132 LKRLLPFLENQSE-DCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPY-DGSVLAS--YG 192
            ....||..:...| :||.||||.|........|.||::||||..||.|:...| |.|:..:  ..
Worm    84 ENLQLPNTDIPDEANCLSLNVFCPQWEIKQSAKHPVMIFIHGGGFELSASKDYCDYSLSGTLPLK 148

  Fly   193 EVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGT 257
            :|:|||:|||:|.||||....:    :...|:||.|...||.|:..:|..|||||.:|||.|...
Worm   149 DVIVVTVNYRVGALGFLTTGDD----SCRGNFGLWDLTLALKWVSTHISSFGGDPKNVTLFGQSA 209

  Fly   258 GAACINYLMTSPTMVRGLFHRAILMSGSAYSSWAL--VEDPVLFAIKLAKEVNCTIPDDINRHHE 320
            ||.|.:.|..|| ..|.|||:.|:|||||:..:|:  .|:..|..::.|:....:     .....
Worm   210 GAVCADLLNLSP-YSRDLFHKLIIMSGSAHVPFAIRTEENQALVCMEYARSRGFS-----GSGSA 268

  Fly   321 QIVDCLRDVPLEDL-------YLADIQAPNFLTSFGPSVDGVVI-RPGHSNLDIDDLMARNSRRS 377
            ::::...::|:|.|       :...|.     .||.|::||... :|      :::| .|.:|:.
Worm   269 ELLEFFENLPIEKLLEKTGLKHTVSID-----LSFAPNLDGDFFPKP------LEEL-RRETRKK 321

  Fly   378 SADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWR 442
            ....|.....                |..::|..|.|                    .|.|
Worm   322 PVIVGMMEDE----------------GLITAFADGDF--------------------TTCE---- 346

  Fly   443 FSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDW-DRTSQHPINTRDTAVAALS 506
               .:.:...|.|.|..:    |.|..|...|     |:|.||:: |.:.:..:
Worm   347 ---ENFKRRVESEYRGDV----VENPENVQKN-----IMNFYTNYCDESEERKL----------- 388

  Fly   507 DAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRC-YFYVFDYQTKDGD 570
             ..::                        |....||....||.|...:|.| ||||||:...||.
Worm   389 -VDYI------------------------GHSVYNAGVLLSAESLARAGNCVYFYVFDFWNPDGF 428

  Fly   571 YP-----QRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHH 630
            .|     ...|..|..:|.||.|..:   :|.|..|  :.:..:.|.:...:||||:.||||
Worm   429 GPVGSIVPFKGAAHCSELRYIIGEGV---YSKFDAN--EKDLKMMEYMTTMFTNFAKYGNPN--- 485

  Fly   631 RQDSSLPVSKERNRFRSIT-WENY 653
                 :|         .:| ||.|
Worm   486 -----IP---------GVTNWETY 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	165/609 (27%)
cest-31	NP_504692.3	COesterase	16..522	CDD:278561	165/609 (27%)
cest-31	NP_504692.3	Aes	<112..>211	CDD:223730	42/102 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810