DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and ace-1

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_510660.1	Gene:	ace-1 / 181706	WormBaseID:	WBGene00000035	Length:	620	Species:	Caenorhabditis elegans

Alignment Length:	727	Identity:	193/727 - (26%)
Similarity:	285/727 - (39%)	Gaps:	195/727 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLGV 73
            ||..:.||:.:::      .....::.|:.|....|.::.|:      ||..|:         |:
Worm     5 LLFFIFLPSTILA------VDLIHLHDGSPLFGEEVLSQTGK------PLTRFQ---------GI 48

  Fly    74 PYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPN--IQNETAALEKMPKGRLEYLKRLL 136
            |:|.||....||...:...||   ||     |:.....||  ||:|.......      |...:.
Worm    49 PFAEPPVGNLRFKKPKPKQPW---RI-----PLNATTPPNSCIQSEDTYFGDF------YGSTMW 99

  Fly   137 PFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSG---NPYDGSVLASYGEVVVVT 198
            ......|||||||||:.|.....| |||.|:|:::|..| ||..   :.|||.:|.....|::|.
Worm   100 NANTKLSEDCLYLNVYVPGKVDPN-KKLAVMVWVYGGGF-WSGTATLDVYDGRILTVEENVILVA 162

  Fly   199 LNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACIN 263
            :|||:.|.|||..| .|.|   ..|.|:.||:.|:.|:.:||..||||.:.:||.|...|||.::
Worm   163 MNYRVSIFGFLYMN-RPEA---PGNMGMWDQLLAMKWVHKNIDLFGGDLSRITLFGESAGAASVS 223

  Fly   264 YLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLF--AIKLAKEVNCTIPDDINRHHEQIVDCL 326
            ..|.||... ..|||||:.||||.|.||:....|..  |:.|...:.|.....||..:::|:||.
Worm   224 IHMLSPKSA-PYFHRAIIQSGSATSPWAIEPRDVALARAVILYNAMKCGNMSLINPDYDRILDCF 287

  Fly   327 RDVPLEDLYLADIQAPNFLTSFG-----PSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSS 386
            :... .|....:..||  :..||     |.|||             |.:..|::.|.....|:.:
Worm   288 QRAD-ADALRENEWAP--VREFGDFPWVPVVDG-------------DFLLENAQTSLKQGNFKKT 336

  Fly   387 AGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIW--RFSAHDI- 448
                                                      .:|.|....|||:  .:...||
Worm   337 ------------------------------------------QLLAGSNRDESIYFLTYQLPDIF 359

  Fly   449 -------QNGFEGER-------RDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRD 499
                   :..|..:|       :|.:.|..::      .......:::||...|.    |:..||
Worm   360 PVADFFTKTDFIKDRQLWIKGVKDLLPRQILK------CQLTLAAVLHEYEPQDL----PVTPRD 414

  Fly   500 TAVA---ALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYV 561
            ...|   .|.|..|..                        |....|.|.|..|     |..|:|.
Worm   415 WINAMDKMLGDYHFTC------------------------SVNEMALAHTKHG-----GDTYYYY 450

  Fly   562 FDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNP 626
            |.::.....:|:.||.:||.::.:|||.||  ....|  |||..|..||...|.:|.|||:||:|
Worm   451 FTHRASQQTWPEWMGVLHGYEINFIFGEPL--NQKRF--NYTDEERELSNRFMRYWANFAKTGDP 511

  Fly   627 NEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEI-------GMKPRIKNHFRAHQLSIWLRL 684
            |::  :|.|         |....|..|:.:..:|:.:       .|| ||.:..|..:.:.|...
Worm   512 NKN--EDGS---------FTQDVWPKYNSVSMEYMNMTVESSYPSMK-RIGHGPRRKECAFWKAY 564

  Fly   685 IPELHRAGMEDV 696
            :|.| .|.:.||
Worm   565 LPNL-MAAVADV 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	181/676 (27%)
ace-1	NP_510660.1	COesterase	13..561	CDD:278561	183/702 (26%)
ace-1	NP_510660.1	Aes	<114..>249	CDD:223730	59/141 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910