DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and cest-13

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_741921.1	Gene:	cest-13 / 181493	WormBaseID:	WBGene00010116	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	749	Identity:	163/749 - (21%)
Similarity:	256/749 - (34%)	Gaps:	242/749 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QLLLLLRLLLL--------PTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSF 61
            :||.:..||||        ||..::.....|::|.          |.:|..||         .||
Worm     2 KLLSVSCLLLLHFASVLADPTYDVTVQTPNGSATI----------RGIQHTYG---------TSF 47

  Fly    62 RFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPK 126
            |         |:.||.||....||...|...| .|:..:..|..:|      :|.:
Worm    48 R---------GIRYAQPPVGLFRFGAARRLDP-VGLVEAQAYGNIC------VQGD--------- 87

  Fly   127 GRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSV--LA 189
            ||..:            ||||::||::|.|. ....||||.|:|||..|....||...|..  |.
Worm    88 GRTSH------------EDCLFINVYTPNNV-TQASKLPVYVYIHGGGFVEGGGNMGAGIYPNLV 139

  Fly   190 SYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAG 254
            :.|.:|:|::|||||..||.:.    .......|:.:.|.:.||:|:|:.|..||||||.||:.|
Worm   140 NKGPIVMVSINYRLGPFGFFST----RQMTAPGNWAISDWIEALNWVQRYISFFGGDPNRVTIGG 200

  Fly   255 HGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSS--WALVEDPVLFAIKLAKEVNCTIPD--DI 315
            ..:||..::.|..:| :.:.||.::|..||||:.:  .:..|.....:.:|:.::.|...|  |.
Worm   201 QSSGAEAVSTLTLTP-LAKNLFKQSIHESGSAFGAAVMSYSEKTRSTSKQLSIKLGCATSDQWDN 264

  Fly   316 NRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSAD 380
            .:....|:.|||:|..:.:..||...|.....:....|...:......|    .:.|:.::
Worm   265 GQSFGTILTCLRNVTYDKIVAADNSLPGHRMKWSIVQDNKYLTQRLEYL----ALQRDPKK---- 321

  Fly   381 SGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESI-WRF- 443
                                                            :||.|.|..|.: |..
Worm   322 ------------------------------------------------NVLIGDVHDEWLGWEMN 338

  Fly   444 -----------SAHDIQNGFEGERRDKIIRTYVRN-------AYNYHLNEIFYTIVNEYTDWDRT 490
                       :||.:::...|...    .||..|       |.|.::|...:|..| :.:|:.
Worm   339 NVLHNINSSHNTAHQMRDDLSGSYE----MTYWDNKQSVLVAADNKYINNQGWTDDN-HREWEA- 397

  Fly   491 SQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSG 555
                     ..:...|:..|:.|.:|                             .:|.......
Worm   398 ---------RRIQLWSEMVFIGPTLR-----------------------------DAAYFQYMKN 424

  Fly   556 RCYFYVFDYQTKDG----DYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIF 616
            ..|.|..|:.:...    ..|...|..|..:|.|||... .:||:     .|..:..|.......
Worm   425 NVYLYSLDWLSPPALPLVTDPLFRGCEHTWELQYIFSTS-CNGFT-----CTAQDEILRNYFTTT 483

  Fly   617 WTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIW 681
            |.||...|||..   ..|.||          ..|...|..: ::|.....|:::.|:....: .|
Worm   484 WLNFIIGGNPTP---AGSPLP----------FKWLAMDSTN-RFLSFSPNPKMQPHYHPDSM-FW 533

  Fly   682 LRLIPELHRAGMEDVIARHNLFRNHDDMDLYEGP 715
            :...|.:                     |.|:||
Worm   534 VCTAPTI---------------------DGYKGP 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	146/667 (22%)
cest-13	NP_741921.1	Abhydrolase	22..510	CDD:304388	147/668 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910