Protein Alignment Nlg4 and cest-3

DIOPT Version :9

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_510042.2
• Gene: cest-3 / 181385
• WormBaseID: WBGene00008451
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 749
• Identity: 170/749 - (22%)
• Similarity: 238/749 - (31%)
• Gaps: 274/749 - (36%)

  Fly    40 GHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYS 104
            |.||:.|.||:|.|..:.:|.       .:|..||:|.||..:.|||......||..||.:.:||
 Worm    20 GQRIISTTYGKLEGKTVNVDQ-------HMFKNVPFAKPPLGKLRFSLPEWTNPWKNIRNATEYS 77

  Fly   105 PVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANE-----KKL 164
            |.|      ..|.:...:          ....|    .||||||||||:      ||     |..
 Worm    78 PSC------FSNSSMRTD----------SNFFP----MSEDCLYLNVFT------NEYCLKSKNC 116

  Fly   165 PVIVFIHGESFEWSSGNPY-DGSVLASY--GEVVVVTLNYRLGILGFLNANPN---PHAHARVAN 223
            ..:|:.||......|...: |..:|..|  ..||.:...|||||.|.|....|   |.      |
 Worm   117 STVVYYHGGGINMDSAVQFNDTFILERYVKENVVFIIPAYRLGIFGLLYFGSNNLVPQ------N 175

  Fly   224 YGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRG----------LFHR 278
            ..:.|...||.:|.|.|..|||..:.:.|.||..||..        :::.|          |.:|
 Worm   176 LAIHDCELALRFIHQEISNFGGHKDDINLMGHSAGAHI--------SLIFGFSRHIDPDHKLINR 232

  Fly   279 AILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPN 343
            .|::  |...|:.:.|..:......|:.|.| ...::.....:||.|||......|
 Worm   233 IIVL--SPVPSYDMPELLIKNCYDFAERVGC-YKRNVTARDTEIVKCLRKKDARGL--------- 285

  Fly   344 FLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSS 408
                                :.:..|| .|.|.
 Worm   286 --------------------MSMQRLM-ENDRL-------------------------------- 297

  Fly   409 FGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHL 473
                ||....||...|          ...|||..|..:.:       :||.:|...|.......|
 Worm   298 ----YFWNFLAGEPFM----------YRDESIADFKEYAV-------KRDMLIGNTVDEVKWKRL 341

  Fly   474 NEIFYTIVNEYTDWDRTSQ--HPIN-TRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSS---S 532
            .:....|...:.||:...:  |..| ..|:|                          ||:|   |
 Worm   342 KKENPAIAGSFMDWENPYEVAHKFNFYHDSA--------------------------PVNSTYES 380

  Fly   533 STAG---SPGANAAASTSAGST--------QPSGRC----YF---YVFDYQTKDGDYPQRMGTVH 579
            .|.|   |....|.|..:||.|        |||...    ||   :..||.|.|.|
 Worm   381 FTQGIFVSTATYAEAQANAGGTVYLFQSNQQPSSHVSDMQYFVGTHREDYHTSDMD--------- 436

  Fly   580 GEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNR 644
                       ::|.|      |:|         ||  .||.:.|:|:         ||
 Worm   437 -----------IMDTF------YSK---------MI--VNFTKFGSPS---------PV------ 458

  Fly   645 FRSITWENYDPLHQKY--LEI----GMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLF 703
                 ||...|....|  ||:    |:.||::..|....::.|.     ::....:..:.|..
 Worm   459 -----WEPLVPSRMNYYALEVNTEKGIWPRMEEDFHESDVNFWF-----INMTAFDREVTRQK-- 511

  Fly   704 RNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSS 737
            :..:...|...|:.|.|..:.|....|.|...||
 Worm   512 KTSNGTSLTWSPMHPGPVILPTKTNESSSFDISS 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	157/688 (23%)
cest-3	NP_510042.2	Abhydrolase	23..496	CDD:304388	157/688 (23%)
		Aes	<118..>254	CDD:223730	40/151 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900