Protein Alignment Nlg4 and cest-2.2

DIOPT Version :9

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_001256567.1
• Gene: cest-2.2 / 179917
• WormBaseID: WBGene00013874
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 740
• Identity: 164/740 - (22%)
• Similarity: 252/740 - (34%)
• Gaps: 252/740 - (34%)

  Fly    44 VQTRYGRLHGLIL-----PLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKY 103
            :.:|.|.:.|..|     ||.:    ::..||.||||..||....||...|.|.||||:..:.:|
 Worm    22 LSSRTGTIEGRTLTASYSPLGN----QTGIVFFGVPYVEPPVGNLRFRKPRPPKPWDGVLEAKEY 82

  Fly   104 SPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANE-KKLPVI 167
            ...|      :.::....:....|.:             ||||||.|||:  |....| |...|:
 Worm    83 KAAC------MSDQKKTYKNGVGGPV-------------SEDCLYANVFT--NQYCLEHKNCSVM 126

  Fly   168 VFIHGESFEWSSGNPYDGSVLAS--YGE---VVVVTLNYRLGI--LGFLNANPNPHAHARVANYG 225
            :.|||..|...|.:.||..::.:  .|:   :||||.|||||:  ||.||.:...      .|:|
 Worm   127 LTIHGGRFVIESASAYDPEIIINNFVGQGRNIVVVTFNYRLGLFGLGMLNGDNQD------TNFG 185

  Fly   226 LMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSA--YS 288
            |.|.:..:.|.::.|:.||||.:.:|:.||..||.......||| :.:||.|:.|:||.|.  .|
 Worm   186 LYDILEVVRWTRKEIKNFGGDKDRITMQGHSAGAVFTAAFSTSP-LSKGLIHQQIIMSASMSNLS 249

  Fly   289 SWALVEDPVLFAIKLAKEVNCTIPDD------INRHHEQIVDCLRDVPLEDLYLADIQAPNFLTS 347
            ..:.|::..:    :|:.|.| :||:      .|...|:...|||....:.:
 Worm   250 KKSNVKELTV----VARIVGC-LPDEHGFPKLSNVEVEKAYTCLRSKSAQQI------------- 296

  Fly   348 FGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGG 412
                            ||....|.||:.
 Worm   297 ----------------LDAQLYMLRNTT------------------------------------- 308

  Fly   413 YFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIF 477
            |:.|.        ||.|.::.|...:::                              |..|.|:
 Worm   309 YYIGQ--------GHIDGIYQVDYPDNL------------------------------YATNSIY 335

  Fly   478 YTIVNEYTDWDRTSQHPINTR-DTAVAALSDAQFVAPIVRAG--DILAAN---------SPPPVS 530
                            ||||. .|..|.|.|::::......|  :||..|         ...|..
 Worm   336 ----------------PINTMIGTTTAELMDSRYIVDPKNTGKKEILLQNLCEHIGYELYKEPEE 384

  Fly   531 SSSTAGSPGANAAASTSAGS---------------TQPSGRCYFYVFDYQTKDG---DYPQRMGT 577
            .|....:...|...:.|.|.               :......:.|.|||:....   .|.:.:..
 Worm   385 FSQKCRNFYKNGEDAKSLGDDMEFYYGAIQLANVHSSKDTNVFVYSFDYKEAGNAYKKYDKSLSP 449

  Fly   578 VHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKER 642
            .||||..|.||..        ..|::..:..:.......:.:|...|:|:....|:
 Worm   450 KHGEDFAYAFGTN--------RGNFSTKDYVIEYIYSGMFADFVNFGDPSPLEDQE--------- 497

  Fly   643 NRFRSITWENYDPLHQKYLEIGM-----KPRIKNHFRAHQLSIW----LRLIPELHRAGMEDVIA 698
                   |..|.|..::|..|..     .|.:|:|:....|..|    .:...| |.:...|:..
 Worm   498 -------WAQYTPEKREYFLIDFDKNFTMPGMKDHYYPKALEFWSTCGSKSFKE-HFSPSVDIFI 554

  Fly   699 RHNLFR------NHDDMDLYEGPVK 717
            ..||..      ||::    .||.|
 Worm   555 IGNLLNPIMSHLNHNE----TGPDK 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	153/692 (22%)
cest-2.2	NP_001256567.1	Abhydrolase	25..534	CDD:389770	153/689 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000