Protein Alignment Nlg4 and cest-34

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_001360105.1
• Gene: cest-34 / 179057
• WormBaseID: WBGene00019652
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 679
• Identity: 166/679 - (24%)
• Similarity: 245/679 - (36%)
• Gaps: 239/679 - (35%)

  Fly    65 RSVEVFLGVPYATPPTKQNRFSPTRAPAP---WDGIRISDKYSPVCPQRLPNIQNETAALEKMPK 126
            :.|..:||:|||.|||.:.||:   .|.|   |...|...||.|.||   |:.|.....:...|.
 Worm    34 KEVHGYLGMPYAKPPTGEMRFA---KPVPADDWTETRDCTKYGPRCP---PSGQGLEKGMFVNPD 92

  Fly   127 GRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKKL-PVIVFIHGESFEWSSGNPY-DGSVLA 189
                         |....:.|.:|||.|....:..|.. ||:|::||..||.||...: |.|:.:
 Worm    93 -------------EPDEANGLSVNVFVPGWESSEYKNARPVMVYVHGGGFEISSSREFCDYSISS 144

  Fly   190 S--YGEVVVVTLNYRLGILGFLNANPN--PHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSV 250
            :  ..:|::||:|||||||||......  |      .|:||.||..||.|:|::|..||||||:|
 Worm   145 TLPMKDVILVTMNYRLGILGFFTTGDEVCP------GNFGLWDQTLALQWVQKHIASFGGDPNNV 203

  Fly   251 TLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDI 315
            ||.|...|.||::.|..||.. |.||.:.:.|||||...         ||::.| |....:.|||
 Worm   204 TLFGQSAGGACVDLLTLSPHS-RDLFQKVVPMSGSAMCE---------FAMRTA-ENEAHVFDDI 257

  Fly   316 -------NRHHEQIVDCLRDVPLEDL-----YLADIQAPNFLTSFGPSVDGVVI-RPGHSNLDID 367
                   ....::.::.:|.:|.:.:     |  ..:...|: |..|:.||... :|      :|
 Worm   258 LARLGFTGSGSKERLEFMRSLPCDKITGKTGY--TYKQSGFM-SLCPNYDGDFFPKP------LD 313

  Fly   368 DLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLF 432
            :|....|:|.                                                    ::.
 Worm   314 ELRKDASKRI----------------------------------------------------LMT 326

  Fly   433 GVVTGES-IWRFSAH--------------------DIQNGFEGERRDKIIRTYVRNAYNYHLNEI 476
            |:|..|. ::.|..:                    |:.:..||.|:: |...|.:|
 Worm   327 GIVGNEGLLFAFDRNTPYKDYTDLLRLKIEEDYKEDVVDDVEGIRKE-IFEYYTKN--------- 381

  Fly   477 FYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGAN 541
                              |:..|........|:||      ||.:.              ..|..
 Worm   382 ------------------ISEGDEEAIMRKAAEFV------GDSIF--------------HTGVR 408

  Fly   542 AAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQR-----MGTVHGEDLPYIFGAPLVDGFSHFPQN 601
            |.|..:|   :.....:.|.|||...||..|.:     :...||.:|.|:||..::..|..
 Worm   409 ATAQNAA---EHGDEVWLYNFDYCNPDGFAPLKGYLPYIEPTHGMELRYLFGDGIISKFEP---- 466

  Fly   602 YTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMK 666
             |:.|..:.:.....:.|||:.|||||                ..|..||.:||
 Worm   467 -TEEELKMLDKFTTMFANFAKYGNPNE----------------TGSSAWEKFDP----------- 503

  Fly   667 PRIKNHFRAHQLSIWLRLIPELHRAGMED 695
            .|...|:|.           ....:||||
 Worm   504 ARPGRHYRI-----------SYPNSGMED 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	162/663 (24%)
cest-34	NP_001360105.1	COesterase	15..517	CDD:395084	162/673 (24%)