Protein Alignment Nlg4 and cest-33

DIOPT Version :9

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_504621.1
• Gene: cest-33 / 179020
• WormBaseID: WBGene00017431
• Length: 554
• Species: Caenorhabditis elegans
• Alignment Length: 661
• Identity: 172/661 - (26%)
• Similarity: 242/661 - (36%)
• Gaps: 200/661 - (30%)

  Fly    67 VEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEY 131
            |:.:||:|||.||..:.||........|..|:...||.|.|.|        |...|::...|
 Worm    36 VDGYLGIPYAKPPVGELRFKKPVTVDVWTEIKDCYKYGPACVQ--------TGGFEQIAGPR--- 89

  Fly   132 LKRLLPFLENQSEDCLYLNVFSPVNAGANEKK-LPVIVFIHGESFEWSSGN---PYDGSVLASYG 192
                .|..|...  ||.||||:|.||.:..|. .||:|:|||..:|..:.:   .|..|......
 Worm    90 ----TPTPEEAG--CLTLNVFTPRNASSEFKNGRPVMVYIHGGGYELCASSDFCAYSLSGTLPLK 148

  Fly   193 EVVVVTLNYRLGILGFLNANPN--PHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGH 255
            :||||::|||||:.|||....|  |      .|:||.||..||.|:|::|..||||||.||:.|.
 Worm   149 DVVVVSINYRLGVFGFLTTGDNVCP------GNFGLWDQTLALKWVQKHISSFGGDPNCVTVFGQ 207

  Fly   256 GTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHH- 319
            ..|.|..:.|..||.. |.||.|.|.:||:|:..         |||: |.|....|..:....|
 Worm   208 SAGGASTDLLSLSPHS-RDLFQRFIPISGTAHCD---------FAIR-ASENQAKIFREFAEFHG 261

  Fly   320 --------------EQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVI-RPGHSNLDIDDL 369
                          ||..:.|.:|   ..|...|.  .||| |.|::||... :|      :|:|
 Worm   262 FSGRDSSALFKWYQEQSPETLSNV---KGYKKSIS--GFLT-FIPNLDGDFFPKP------LDEL 314

  Fly   370 MARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGV 434
            .....::....                             |...:.|....:||..
 Worm   315 RKEAPKKQMMT-----------------------------GVTEYEGLMLASMNPA--------- 341

  Fly   435 VTGESIWRFSAHDI-----QNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDW-DRTSQH 493
                    ||..|:     ..|..|       :..|.|.  ..:.:|||   .:|.:. |::.:
 Worm   342 --------FSPADVGLTLMPQGIYG-------KDVVSNP--DEIQKIFY---EKYVEGVDKSDE- 385

  Fly   494 PINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCY 558
             :..|.....||.|..|...:::|                     ..|||        :.....|
 Worm   386 -LAMRKKLCEALGDEFFNVGVIQA---------------------AKNAA--------KHGNEVY 420

  Fly   559 FYVFDYQTK------DGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFW 617
            ||.|:|...      ||..|.: ..||..:|.|:.|..:...|..     |:.:..:.|.....:
 Worm   421 FYTFEYVNPDSFGMWDGMMPFK-AAVHCTELRYLLGEGVYSKFEP-----TEEDRKVMETTTTLF 479

  Fly   618 TNFARTGNPN------------------EHHRQDSSLPVSKERNRF---RSITWENYDPLHQKYL 661
            :|||:.||||                  .|:|  .|.|..:.|:.:   |....|..|....||.
 Worm   480 SNFAKYGNPNGKGATAEIWEKYSLNRPERHYR--ISYPKCEMRDVYHEGRIQFLEKIDGDSDKYQ 542

  Fly   662 EI--GMKPRIK 670
            |:  |.|...|
 Worm   543 ELVYGKKKSAK 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	172/661 (26%)
cest-33	NP_504621.1	Esterase_lipase	16..521	CDD:238191	162/627 (26%)
		Aes	<103..>224	CDD:223730	53/127 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810