Protein Alignment Nlg4 and cest-24

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_504613.1
• Gene: cest-24 / 179017
• WormBaseID: WBGene00020891
• Length: 658
• Species: Caenorhabditis elegans
• Alignment Length: 746
• Identity: 185/746 - (24%)
• Similarity: 275/746 - (36%)
• Gaps: 213/746 - (28%)

  Fly    35 KGARLGHRIVQTRYGRLHGLILPLDSFRFLRS----VEVFLGVPYATPPTKQNRFSPTRAPAPWD 95
            |..:..:.||:.:.|.|.|       ||...:    .:||.|:|||.||..:.||...:.|..|:
 Worm    89 KSGKSENAIVRVQQGLLEG-------FRVKTAKGDLCDVFHGIPYAEPPVGELRFQKPQPPKAWE 146

  Fly    96 GIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGAN 160
            |||..:||    |.|  :|..|....:.:|..             ||||||||||||:|  ....
 Worm   147 GIRKCNKY----PNR--SIHKEMPWDKALPSA-------------NQSEDCLYLNVFAP--KIRE 190

  Fly   161 EKKLPVIVFIHGESFEWSSGNPYDG----SVLASYGEVVVVTLNYRLGILGFLNANPN--PHAHA 219
            :||.||:.:|||..:...|...|..    .:|.| .|::|||.:||||.||||:...:  |
 Worm   191 DKKYPVLFYIHGGGYVMDSAERYTAKNICKLLVS-REIIVVTFHYRLGFLGFLSTGDDVCP---- 250

  Fly   220 RVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSG 284
              .||||.|.:.|:.|:..||..|||||.::||:|...|||..:.|..|| :.:|||.|.|:|.|
 Worm   251 --GNYGLFDMLEAMRWVHANISSFGGDPENITLSGQSAGAAAADLLSFSP-LTKGLFKRKIVMGG 312

  Fly   285 SAYSSWALVEDPVL--FAIKLAKEVNCTIPDDINRHHEQIVDC---LRDVPLEDLYLA------- 337
            ::|..||...:..:  :..|.||.:......:.....|:.||.   ...:|...|.:.
 Worm   313 NSYCHWATTSNHDIREYCKKWAKRLGWKPQLNYANKREESVDIFNFFNGLPTSKLGMTMFFSNTI 377

  Fly   338 --DIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGG 400
              :.|.|     ..|.:||.::.        .||......:....|
 Worm   378 FKECQLP-----LAPVIDGEILP--------HDLKVLRETQEHVPS------------------- 410

  Fly   401 GGGGSGSSFGGGYFGGSGAGTMNMGGHYDVL----FGVVTGESIWRFSAHDIQNGFEGERRDKII 461
                                 :..||.|:.|    .|::.|......||.|:.:     |::::.
 Worm   411 ---------------------LVGGGEYEALLFCAIGLLRGTEKEINSAIDVLS-----RKNRLS 449

  Fly   462 RTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSP 526
            |:.:.     .:.|..|            ...|....|:....:...|.::.|.
 Worm   450 RSKIE-----AMTEKVY------------GDSPALRADSKARKMFFVQLISDIF----------- 486

  Fly   527 PPVSSSSTAGSPGANAAASTSAGSTQPSG-RCYFYVFDYQTKD-GDYPQRM----GTVHGEDLPY 585
                         ||..........|..| .||.|.||:|:|. ..:.|.:    |..|..:|.|
 Worm   487 -------------ANYGNYRFMRDCQQRGVECYGYSFDHQSKQMWGWLQHVVPFTGGTHTSELSY 538

  Fly   586 IFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITW 650
            :|..    .:...|....|::..:|.....::|||.:.|.||   ..:|.||           .|
 Worm   539 LFDC----NYMSAPLGMNKTDKVVSGMTADYFTNFVKFGTPN---GPNSQLP-----------KW 585

  Fly   651 ENYDP--LHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDLYE 713
            |...|  .|.|.:.|..:|.:|.....:                      |...|.:|..| |||
 Worm   586 ERISPDDEHMKLISIKPEPEMKTTVYGY----------------------RMQNFEDHLGM-LYE 627

  Fly   714 GPVKPDPFGISTAAGASGSSSSSSSSSRLLL 744
            ...| .||........|..||.|.:|..:::
 Worm   628 EKDK-SPFSPRGNFKPSIVSSGSDNSLHIMV 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	169/673 (25%)
cest-24	NP_504613.1	COesterase	97..608	CDD:395084	168/663 (25%)