DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and cest-24

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_504613.1	Gene:	cest-24 / 179017	WormBaseID:	WBGene00020891	Length:	658	Species:	Caenorhabditis elegans

Alignment Length:	746	Identity:	185/746 - (24%)
Similarity:	275/746 - (36%)	Gaps:	213/746 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 KGARLGHRIVQTRYGRLHGLILPLDSFRFLRS----VEVFLGVPYATPPTKQNRFSPTRAPAPWD 95
            |..:..:.||:.:.|.|.|       ||...:    .:||.|:|||.||..:.||...:.|..|:
Worm    89 KSGKSENAIVRVQQGLLEG-------FRVKTAKGDLCDVFHGIPYAEPPVGELRFQKPQPPKAWE 146

  Fly    96 GIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGAN 160
            |||..:||    |.|  :|..|....:.:|..             ||||||||||||:|  ....
Worm   147 GIRKCNKY----PNR--SIHKEMPWDKALPSA-------------NQSEDCLYLNVFAP--KIRE 190

  Fly   161 EKKLPVIVFIHGESFEWSSGNPYDG----SVLASYGEVVVVTLNYRLGILGFLNANPN--PHAHA 219
            :||.||:.:|||..:...|...|..    .:|.| .|::|||.:||||.||||:...:  |
Worm   191 DKKYPVLFYIHGGGYVMDSAERYTAKNICKLLVS-REIIVVTFHYRLGFLGFLSTGDDVCP---- 250

  Fly   220 RVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSG 284
              .||||.|.:.|:.|:..||..|||||.::||:|...|||..:.|..|| :.:|||.|.|:|.|
Worm   251 --GNYGLFDMLEAMRWVHANISSFGGDPENITLSGQSAGAAAADLLSFSP-LTKGLFKRKIVMGG 312

  Fly   285 SAYSSWALVEDPVL--FAIKLAKEVNCTIPDDINRHHEQIVDC---LRDVPLEDLYLA------- 337
            ::|..||...:..:  :..|.||.:......:.....|:.||.   ...:|...|.:.
Worm   313 NSYCHWATTSNHDIREYCKKWAKRLGWKPQLNYANKREESVDIFNFFNGLPTSKLGMTMFFSNTI 377

  Fly   338 --DIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGG 400
              :.|.|     ..|.:||.::.        .||......:....|
Worm   378 FKECQLP-----LAPVIDGEILP--------HDLKVLRETQEHVPS------------------- 410

  Fly   401 GGGGSGSSFGGGYFGGSGAGTMNMGGHYDVL----FGVVTGESIWRFSAHDIQNGFEGERRDKII 461
                                 :..||.|:.|    .|::.|......||.|:.:     |::::.
Worm   411 ---------------------LVGGGEYEALLFCAIGLLRGTEKEINSAIDVLS-----RKNRLS 449

  Fly   462 RTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSP 526
            |:.:.     .:.|..|            ...|....|:....:...|.::.|.
Worm   450 RSKIE-----AMTEKVY------------GDSPALRADSKARKMFFVQLISDIF----------- 486

  Fly   527 PPVSSSSTAGSPGANAAASTSAGSTQPSG-RCYFYVFDYQTKD-GDYPQRM----GTVHGEDLPY 585
                         ||..........|..| .||.|.||:|:|. ..:.|.:    |..|..:|.|
Worm   487 -------------ANYGNYRFMRDCQQRGVECYGYSFDHQSKQMWGWLQHVVPFTGGTHTSELSY 538

  Fly   586 IFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITW 650
            :|..    .:...|....|::..:|.....::|||.:.|.||   ..:|.||           .|
Worm   539 LFDC----NYMSAPLGMNKTDKVVSGMTADYFTNFVKFGTPN---GPNSQLP-----------KW 585

  Fly   651 ENYDP--LHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDLYE 713
            |...|  .|.|.:.|..:|.:|.....:                      |...|.:|..| |||
Worm   586 ERISPDDEHMKLISIKPEPEMKTTVYGY----------------------RMQNFEDHLGM-LYE 627

  Fly   714 GPVKPDPFGISTAAGASGSSSSSSSSSRLLL 744
            ...| .||........|..||.|.:|..:::
Worm   628 EKDK-SPFSPRGNFKPSIVSSGSDNSLHIMV 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	169/673 (25%)
cest-24	NP_504613.1	COesterase	97..608	CDD:278561	168/663 (25%)
cest-24	NP_504613.1	Aes	<183..>285	CDD:223730	44/110 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910