Protein Alignment Nlg4 and cest-35.1

DIOPT Version :9

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_504400.1
• Gene: cest-35.1 / 178912
• WormBaseID: WBGene00015067
• Length: 545
• Species: Caenorhabditis elegans
• Alignment Length: 706
• Identity: 159/706 - (22%)
• Similarity: 252/706 - (35%)
• Gaps: 219/706 - (31%)

  Fly    36 GARLGH-------RIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAP 93
            |..|.|       .::....|.:.|.|...|.    :.|:.:||:|:|..|..:.||..:.....
 Worm     2 GGFLSHLKPEHNTEVLNASCGPIRGNIYEHDD----KIVDGYLGIPFAKAPIGELRFKKSVEAEK 62

  Fly    94 WDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAG 158
            |.......||.|.|||        :.||..|...:...::      |...::||.||||:|....
 Worm    63 WTEPLDCYKYGPGCPQ--------SGALGAMIVPQASAIR------EFAEDNCLTLNVFAPKWKS 113

  Fly   159 AN-EKKLPVIVFIHGESFEWSSGNPYDGSVLAS---YGEVVVVTLNYRLGILGFLNANPNPHAHA 219
            |. ...|||||:.:|..||....:.:|...|..   ..:|::||.|||:|.|||.....:    .
 Worm   114 AEFPNGLPVIVYFYGGGFEVGFSSMFDDYSLTGTLPLKDVILVTPNYRIGPLGFFATGDD----V 174

  Fly   220 RVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSG 284
            ...|:||.||..||.|:|::|:.|||||::||::|...|.|.:::|..|| .....||:.|.|||
 Worm   175 SRGNWGLWDQALALQWVQKHIKSFGGDPSNVTISGTSAGGASVDFLSLSP-HANKYFHKFIPMSG 238

  Fly   285 SAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFG 349
            :|...         |.|: :|:|...|..:..:||
 Worm   239 AATCP---------FGIR-SKDVEGLIFREFAKHH------------------------------ 263

  Fly   350 PSVDGVVIRPGHSNLDIDDLM----ARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSG---- 406
                      |::..|.:.|:    ::::.......||:..|                 ||
 Worm   264 ----------GYAGNDSESLLHWYQSQDAEIFLKAEGFKYPA-----------------SGMFSF 301

  Fly   407 -SSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFE----GERRDKIIRT--- 463
             .::.|.:|..............|.:..|...|.:          |||    |::..:.:.|
 Worm   302 VPNYDGDFFPKPFDELRKEAPKLDAIVSVAEYEGL----------GFEEFYPGQKSPQEVLTAAL 356

  Fly   464 ---YVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTA--------VAALSDAQFVAPIVRA 517
               .|||.     .|:....|..|.:         |..|.:        |....|..|...:.
 Worm   357 GPEVVRNR-----EEVVKKAVEAYLE---------NIEDKSGEKIGKKLVEIFGDYYFSVGVF-- 405

  Fly   518 GDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKD-----GDYPQRMGT 577
                     ..|.|.:..|:                  ..|...|:|...:     |:.......
 Worm   406 ---------DTVRSLAKYGN------------------NVYLSSFNYFNPETPIMFGENRPFNAA 443

  Fly   578 VHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKER 642
            .||.|:.||.|    ||...|    :|.:..:.:.:..:.||||:.||||
 Worm   444 SHGCDIRYILG----DGIGEF----SKEDRKVMDMMGTYLTNFAKYGNPN--------------- 485

  Fly   643 NRFRSITWENY---DPLHQKYLEIGM-KPRIKNHFRAHQLSIWLRLIPELHRAGME 694
            .:..||.||.|   :|  .:|.:|.. |..:.::|    |....::|.|::..|::
 Worm   486 GKGVSIPWEKYSLDNP--GRYFKIDYPKCEMADNF----LDGRYKIIDEVNEHGIQ 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	153/677 (23%)
cest-35.1	NP_504400.1	COesterase	14..516	CDD:278561	151/669 (23%)
		Aes	<106..>214	CDD:223730	42/111 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810