Protein Alignment Nlg4 and cest-10

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_501133.3
• Gene: cest-10 / 177493
• WormBaseID: WBGene00016595
• Length: 579
• Species: Caenorhabditis elegans
• Alignment Length: 676
• Identity: 133/676 - (19%)
• Similarity: 231/676 - (34%)
• Gaps: 221/676 - (32%)

  Fly    43 IVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVC 107
            ||:|..|:|:|     |.   :.:..:|..:|:|.||..:.||...:....|:|:|.:..|.|.|
 Worm    23 IVETSLGKLNG-----DQ---IGNFHLFKKIPFAKPPLGKLRFQKPQPAETWNGVRNAKDYGPAC 79

  Fly   108 PQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHG 172
            ...    .:.|..::|.                 ..||||:||:|:.... ...|...|::::||
 Worm    80 MSN----SSTTKTVQKW-----------------VDEDCLHLNIFTSETC-LKSKNCAVVIYLHG 122

  Fly   173 ESFEWSSGNPY-DGSVLASYG--EVVVVTLNYRLGILGFL-----NANPNPHAHARVANYGLMDQ 229
            .:..:.|...: |..:|.:|.  |:|.|....||||....     :..||        |..|.|.
 Worm   123 GNLHYDSAVMFNDTFLLHTYASQEIVFVIPAVRLGIFSHFVVEDQSIAPN--------NLALFDM 179

  Fly   230 MAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVR---GLFHRAILMSGSAYSSWA 291
            :.|:.:.:.:|..|||:....||.||..|....:.|..| |.|.   .||.:.|.||..  :::.
 Worm   180 LQAMEFAKSDIHNFGGNNKRTTLLGHSYGGTVASMLSFS-TKVNTDLSLFQQYISMSSP--TNFD 241

  Fly   292 LVEDPVLFAIKLAKEVNCTIPDD---INRHHEQIV--DCLRDVPLEDLYLADIQAPNFLTSFGPS 351
            .:|..|....:.|:..|| :|.:   :.::.:::.  |||:.....:|.
 Worm   242 TLELQVERTYRFAEHANC-LPKNSKFMRKNQKEVYMRDCLKKKSASELL---------------- 289

  Fly   352 VDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGG 416
                                 ..:||..::|:.                            .:||
 Worm   290 ---------------------RIQRSLEEAGYP----------------------------VYGG 305

  Fly   417 SGAGTMNMGGHYDVLFGVVTGESIWR---FSAHDIQNGFEGERRDKIIRTYVRNA------YNY- 471
            |            |:.|.:..|.:.|   .|.::|.:.....:.:.::..:.||.      .||
 Worm   306 S------------VMRGPIFQEVLERDFMDSPNNITSLTGCTKYESLVYDHYRNMGKALGFENYE 358

  Fly   472 HLNEIFYTIVNE-YTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTA 535
            .:||.:.:...| ..::|       |.::.....|...:     .|...||..|.|.
 Worm   359 EVNEKYRSDSKEGKIEFD-------NVKNATQIMLIQIR-----TRVNKILKKNIPA-------- 403

  Fly   536 GSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGA-PLVDGFSHFP 599
                                    |.::|.     ||:...  |.:||.:|.|. |.:.
 Worm   404 ------------------------YHYEYA-----YPKHAN--HTDDLFFIMGVHPFIQ------ 431

  Fly   600 QNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIG 664
               .::|..|.......:.||.:||||.     :.....:...:.:..:.|..         ..|
 Worm   432 ---DENEIKLGNFYRSMFLNFIKTGNPG-----NGCDGANLNGSTYFEVNWNE---------TTG 479

  Fly   665 MKPRIKNHFRAHQLSIWLRLIPELHR 690
            .:|.:||:|....|..|.:.:.|..|
 Worm   480 ERPVMKNNFEQKILDYWTKNMIEFDR 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	130/665 (20%)
cest-10	NP_501133.3	alpha/beta hydrolases	20..503	CDD:473884	131/672 (19%)