Protein Alignment Nlg4 and cest-25

DIOPT Version :9

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_497609.1
• Gene: cest-25 / 175390
• WormBaseID: WBGene00022178
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 680
• Identity: 161/680 - (23%)
• Similarity: 255/680 - (37%)
• Gaps: 187/680 - (27%)

  Fly    42 RIVQTRYGRLHGLILPLDSFRFL----RSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDK 102
            |.|.|.||       |::..|.:    :.|:.|.|:|||.||....||:..:....|..:|.:..
 Worm    17 RQVLTSYG-------PIEGRRLIHEGEKQVDAFQGIPYAAPPIGNLRFALPQPHEKWTEVRETKS 74

  Fly   103 YSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKKLPVI 167
            :.      ...||.:..               |.|....||||.|.||:|:||....||...|||
 Worm    75 FG------ARGIQKDHV---------------LSPKTSPQSEDNLTLNIFTPVWTPKNETGFPVI 118

  Fly   168 VFIHGESFEWSSGNPYDGSVLASY---GEVVVVTLNYRLGILGFLNANPN--PHAHARVANYGLM 227
            ::|||..|...|.:.|....:..:   .:|||||:.||||.|||.....:  |.      |..|.
 Worm   119 LYIHGGGFVSDSAHKYGDMSICQHLVTKDVVVVTIQYRLGFLGFWTTGDSSIPD------NVALH 177

  Fly   228 DQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWAL 292
            |.:.||.|:::||..|.||||::||.|...|.|.:::|..|| :.|.||.:.|.|.|:|..|||:
 Worm   178 DMVFALKWVKENIGLFNGDPNNITLMGQSAGGASVDFLSISP-VSRDLFQKVIPMGGNASCSWAI 241

  Fly   293 VEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLA-DIQAPNFLTS----FGPSV 352
            ...|:......|:|:.  :.|.:|.  ...|:.||::|.:....| :::|.:..|.    .||..
 Worm   242 HPRPLNACRNRAQEIG--VFDGMNT--LDWVEKLRELPADKFASALNMEAVDTKTDPELLIGPKY 302

  Fly   353 DGVVI-RPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGG 416
            |.:.| ||      :.:|......:...
 Worm   303 DNLFIPRP------VMELRKEAPMKPRL------------------------------------- 324

  Fly   417 SGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIV 481
              .|.....|.....||:.|     :...|.:|........:|:.....|: |.....|....|.
 Worm   325 --LGCAKSEGLVFAFFGLNT-----KHPLHAVQQDVSAILSEKLFPLKARD-YQEKALEKLIEIG 381

  Fly   482 NEYT--DWDRTSQHPINTRDTAVAALSDAQFVAPIVRAG--DILAANSPPPVSSSSTAGSPGANA 542
            .:::  :|.|           |:..|....|:...::..  |:|
 Worm   382 TDHSKEEWQR-----------AMVDLKGDSFLNVGIQQNVLDVL--------------------- 414

  Fly   543 AASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMG----------TVHGEDLPYIFGAPLVDGFSH 597
                   .||||...|.|.|||..     |:..|          ..|..|:.|:.|..:|:.|
 Worm   415 -------ETQPSTPIYMYSFDYCN-----PKAYGIMGFKLPFKDATHCTDISYVVGNHIVNSF-- 465

  Fly   598 FPQNYTKSETALSEAVMIFWTNFARTGNPNEH-----HRQDSSLPVSKERNRFRSITWENYDPLH 657
               ::.:.:..:.|.....|||||:.||||..     |.::...|.:.|            .|
 Worm   466 ---DFNEEDYKMIEITTRLWTNFAKYGNPNGEGDDVAHLEEKWEPATIE------------SP-- 513

  Fly   658 QKYLEIGMKPRIKNHFRAHQLSIWLRLIPE 687
            |.::.:.::|::.:.::..:.....:|:.|
 Worm   514 QTHMALTLQPKLHHVYKQGRPLFMAKLLKE 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	158/671 (24%)
cest-25	NP_497609.1	COesterase	18..536	CDD:365897	158/670 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810