DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and ace-4

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_496962.1	Gene:	ace-4 / 175074	WormBaseID:	WBGene00000038	Length:	602	Species:	Caenorhabditis elegans

Alignment Length:	699	Identity:	187/699 - (26%)
Similarity:	275/699 - (39%)	Gaps:	186/699 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 IVQTRYGRLHGLILPLDSFRFL-RSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPV 106
            :::|:.|.:.|     ..|.|| :.:..|.|||:|.|..:..||...|....|.|:..:.|.:..
Worm    28 VLETKLGDIKG-----TEFFFLSKKIRTFFGVPFAEPAVEDFRFRKPREKKQWRGLYDATKPANA 87

  Fly   107 CPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIH 171
            |.|...| .|.:....:|.....:.           ||||||||:::|.:|    ..|.|:|:..
Worm    88 CFQTRDN-YNTSFWGSEMWNANTQI-----------SEDCLYLNIWAPADA----YNLTVMVWFF 136

  Fly   172 GESFEWSSGNP----YDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAA 232
            |..|  .||:|    |||..|.|...|:||.:|||||..|||... :|.|   ..|.||:||..|
Worm   137 GGGF--YSGSPSLSIYDGKALTSTQNVIVVNINYRLGPFGFLYLG-HPDA---PGNMGLLDQQLA 195

  Fly   233 LHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPV 297
            |||::|||..|||:|:.|.:.|...|||.|...:.:|.. ||||..|||.|||..::|| :..|
Worm   196 LHWVRQNIVSFGGNPDKVAVFGQSAGAASIVAHLIAPGS-RGLFKNAILQSGSLENTWA-INSP- 257

  Fly   298 LFAIKLAKE-----VNCTIPDDINRHHEQIVD----CLRDVPLEDLYLAD-------IQAPNFLT 346
             |..|...|     |.|         ::..||    |||.|..|.|.|:.       ::.|..:.
Worm   258 -FRAKQKSEKLLELVGC---------NKTTVDTSMACLRLVSPEQLSLSTWNISLTYLEFPFVIV 312

  Fly   347 S-----FGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSG 406
            |     ||.......:|.|..|.|::.::..|....:..:.:|...
Worm   313 SRDKHFFGHLDAHAALREGDFNRDVNLMIGMNKDEGNYWNIYQLPQ------------------- 358

  Fly   407 SSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNY 471
                  :|..:....:|. ..:|.|.                      :|...|....:|:|..|
Worm   359 ------FFDKADPPELNR-TEFDFLI----------------------DRTFSIQPDIIRSAAKY 394

  Fly   472 HLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAAL---SDAQFVAPIVRAGDILAANSPPPVSSSS 533
                 .|:..| .||..|.::......:..|...   .|:.::|...|        |.|.|.|||
Worm   395 -----IYSDPN-CTDHGRKTRFYAGQMNQIVGDYFFSCDSLWLADQFR--------SIPRVKSSS 445

  Fly   534 TAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHF 598
            ....|                |:.:.|.|...:....:|:..|.:||.::.|:||.||     .:
Worm   446 PQRKP----------------GKVFVYHFTQSSSANPWPKWTGAMHGYEIEYVFGIPL-----SY 489

  Fly   599 PQNYTKSETALSEAVMIFWTNFARTGNP------NEHHRQDSSLPVSKERNRFRSITW------E 651
            .:||.:.|...|..:|.||.:||:.|.|      |..|     .|...|:|.:|   |      .
Worm   490 SKNYKRREQIFSRKIMQFWASFAKNGTPKLRVLKNSEH-----WPEFNEQNHYR---WMQLRSGS 546

  Fly   652 NYDPLH-QKYLEIGMKPRIKN-HFRAH-----------QLSIWLRL-IP 686
            |..|:. :|.:|.....|:|: .:.|:           ..|.||.| ||
Worm   547 NIRPIKPKKQVECQFWRRVKDTEYTAYLTQEYSSSSLTTYSYWLLLYIP 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	182/691 (26%)
ace-4	NP_496962.1	COesterase	28..562	CDD:278561	178/664 (27%)
ace-4	NP_496962.1	Aes	<120..>243	CDD:223730	56/133 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910