Protein Alignment Nlg4 and ace-2

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_491141.1
• Gene: ace-2 / 171905
• WormBaseID: WBGene00000036
• Length: 629
• Species: Caenorhabditis elegans
• Alignment Length: 752
• Identity: 188/752 - (25%)
• Similarity: 268/752 - (35%)
• Gaps: 223/752 - (29%)

  Fly    40 GHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYS 104
            |..:|.|..|.:.|:....|..:    |..|||||||.||....||........|.|...:...:
 Worm    37 GDHVVHTPLGTIRGVGQTFDGAK----VSAFLGVPYAKPPIGSRRFKMAEMIDRWSGELEARTLA 97

  Fly   105 PVCPQRLPNIQNETAALEKM-PKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIV 168
            ..|...:.:...:....|.. |.|.:             |||||.:|::.|.:...:     |:|
 Worm    98 KTCYLTIDSAFPQFPGAEMWNPPGAI-------------SEDCLNMNIWVPEDHDGS-----VMV 144

  Fly   169 FIHGESFEWSSGNP----YDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQ 229
            :|:|..|  .||.|    |.|||.|:....:||.:|||||..|||....:....   .|.|||||
 Worm   145 WIYGGGF--FSGTPSLDLYSGSVFAAKEHTIVVNVNYRLGPFGFLYFGDDSPIQ---GNMGLMDQ 204

  Fly   230 MAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVE 294
            ..||.|:.:||..||||.:.|||.|...|:|.....:.:|...: .|...|..|||..:|||...
 Worm   205 QLALRWVHENIGAFGGDRSRVTLFGESAGSASTTAHLFAPNSHK-YFRNIIAKSGSIINSWASAT 268

  Fly   295 DPVL--FAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVI 357
            .|.:  .:.:|||:|||:.||     ...||.|||.||   .:|...:|.|.....||.:....:
 Worm   269 PPTMLDLSFRLAKKVNCSSPD-----MNAIVKCLRSVP---AHLVQAEADNISGDIGPPMTFAYV 325

  Fly   358 RPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTM 422
                              ..|:|:.|                         |.|..|  ......
 Worm   326 ------------------PVSSDANF-------------------------FQGDVF--QKLANK 345

  Fly   423 NMGGHYDVLFGVVTGE-SIW----------------RFSAHDIQN-------GFEGERR------ 457
            ......:::||.|..| :.|                ..||.|..|       .:|...|
 Worm   346 QFKKDVNIIFGSVKDEGTYWLPYYMSLPKYGFAFNHTISAEDPHNRALITRDHYEESMRAFMPYF 410

  Fly   458 --DKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINT-RDTAVAALSDAQFVAPIVRAGD 519
              .|::.....|:|. |::               ||..|... ||.....|.|..|...::...|
 Worm   411 AGSKLVLNAFMNSYE-HVS---------------TSNVPEERYRDGVARFLGDLFFTCSLIDFAD 459

  Fly   520 ILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLP 584
            :::.|.                            .|..|.|.|.|::....:|:.||.:||.::.
 Worm   460 LISDNI----------------------------FGNVYMYYFTYRSSANPWPKWMGVMHGYEIE 496

  Fly   585 YIFGAP-----LVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNR 644
            |.||.|     |.|      |.:.:.|..||..:|..|.|||.||      |.||
 Worm   497 YAFGQPYWRPHLYD------QTHLEDEKRLSSIIMQIWANFANTG------RTDS---------- 539

  Fly   645 FRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLF---RNH 706
                .|..|:.:.:|.:|:|.......|          |:|.::| .|...:|.....|   :|.
 Worm   540 ----FWPQYNKIERKAIELGETTLQGKH----------RIISDVH-GGFCRMIDEAKAFVKQKNA 589

  Fly   707 DDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLL 743
            :|..             :|...||....:||||:..|
 Worm   590 NDCR-------------TTRKSASTEDLTSSSSTTYL 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	171/682 (25%)
ace-2	NP_491141.1	COesterase	40..558	CDD:395084	170/668 (25%)