Protein Alignment Nlg4 and cest-27

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_871861.2
• Gene: cest-27 / 171610
• WormBaseID: WBGene00018958
• Length: 561
• Species: Caenorhabditis elegans
• Alignment Length: 676
• Identity: 158/676 - (23%)
• Similarity: 245/676 - (36%)
• Gaps: 230/676 - (34%)

  Fly    67 VEVFLGVPYATPPTKQNRFSPTRAPAPW----DGIRISDKYSPVCPQRLPNIQNETAALEKMPKG 127
            ||.|||:|||.||....||....|...|    |.:|    :.|..|      ||:
 Worm    48 VEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVR----FGPRSP------QND---------- 92

  Fly   128 RLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANE--KKLPVIVFIHGESFEWSSGNPYDGSVLA- 189
              |.|.:.:..:....|.||.||||:| ...:||  ...||:|||||..|...|.:.|..:.:|
 Worm    93 --ELLGQFVNTVGKSEEHCLSLNVFTP-KWESNEWPDGFPVMVFIHGGGFAVHSSSNYGCASIAR 154

  Fly   190 --SYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTL 252
              ...:|||||:|||||:|||.....    .....|.||.||.|||.|:|:|||.|.|||::||:
 Worm   155 NLCTKDVVVVTINYRLGVLGFFTTGD----EVCRGNLGLWDQTAALEWVQENIQSFRGDPDNVTI 215

  Fly   253 AGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWAL--VEDPVLFAIKLAKEVNCTIPDDI 315
            .|...|.|.::.|..||.. ||||:|||.|:|:....:|:  .|.....:.:.|:.:.....|:.
 Worm   216 FGQSAGGASVDLLCLSPHS-RGLFNRAIPMAGNGECDFAMRTSEQQAQLSREFARYLGWEGDDND 279

  Fly   316 NRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSAD 380
            :.      |.|:.:..:.||..:                               |..|.:|
 Worm   280 SE------DLLQFIDQQPLYKIE-------------------------------MGINPKR---- 303

  Fly   381 SGFQSSAGGGGGQGGGAGGGGGGGSGS-----SFGGGYFGGS-------------GAGTMNMGGH 427
             ||:.|.                 :||     :|.|.:|...             ..||....|.
 Worm   304 -GFKHSQ-----------------AGSLYFVPNFDGDFFPKPLNQLRKEAPKMQIMTGTTKYEGL 350

  Fly   428 YDVLFGVVT--GESIWRFSAHDIQNGFEGERRDKII-------------RTYVRNAY-------N 470
            :.:..|.::  .|.|.:|.....:....|||.|.::             :.:.:|.:       :
 Worm   351 FFIALGALSKNPEGIKKFMGRIFKECDYGERADDVLQMVYDFYFKGVHPKDHEKNMHQIVKFIGD 415

  Fly   471 YHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTA 535
            |.:|...|.:.|..||    .||.:
 Worm   416 YSINYGTYRLANIMTD----LQHDV---------------------------------------- 436

  Fly   536 GSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQR-----MGTVHGEDLPYIFGAPLVDGF 595
                                  |||.|||....|....|     :|:.|..::.|:.|..::..|
 Worm   437 ----------------------YFYQFDYHNSAGFGVFRWLLPFLGSTHCTEMRYVLGKGIISKF 479

  Fly   596 SHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQ-K 659
            .  |.:..|.   :...:..::||||:.||||..:::...              |:.:|..|. :
 Worm   480 R--PNDNDKK---MLHVMTTYFTNFAKYGNPNGENQETGE--------------WQKHDSAHPFR 525

  Fly   660 YLEIGM-KPRIKNHFRAHQLSIWLRL 684
            :.:|.: ...:...::..:..:|.:|
 Worm   526 HFKIDLDDSEMVEDYQERRAELWDKL 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	156/671 (23%)
cest-27	NP_871861.2	COesterase	29..548	CDD:395084	156/671 (23%)