Protein Alignment Nlg4 and Nlgn3

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_599163.2
• Gene: Nlgn3 / 171297
• RGDID: 621119
• Length: 848
• Species: Rattus norvegicus
• Alignment Length: 879
• Identity: 286/879 - (32%)
• Similarity: 399/879 - (45%)
• Gaps: 230/879 - (26%)

  Fly    44 VQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCP 108
            |.|.:|:|.|..:||.| ..|..|:.:||||||.||..:.||.|...|..|.|||.:..:.||||
  Rat    44 VNTHFGKLRGARVPLPS-EILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCP 107

  Fly   109 QRLPNIQNETAALEKM-PKGRLEYLKRLLPFLENQSEDCLYLNVFSPV----------------- 155
            |.:     .||..|.| |......|..:..:::..:||||||||:.|.
  Rat   108 QNI-----HTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKK 167

  Fly   156 ---NAGANEKK---------------------LPVIVFIHGESFEWSSGNPYDGSVLASYGEVVV 196
               ..|:..||                     .||:|:|||.|:...:||..|||||||||.|:|
  Rat   168 ICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIV 232

  Fly   197 VTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAAC 261
            :|||||:|:||||:...    .|...||||:||:.||.|:.:||..|||||..:|:.|.|.||:|
  Rat   233 ITLNYRVGVLGFLSTGD----QAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASC 293

  Fly   262 INYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCL 326
            :: |:|......|||.|||:.||||.||||:...||.:...||.:|.|.:.|.::     :||||
  Rat   294 VS-LLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVD-----MVDCL 352

  Fly   327 RDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGG 391
            |....::|...|||...:..:|||.:||.||..     |.:.||.:
  Rat   353 RQKSAKELVEQDIQPARYHVAFGPVIDGDVIPD-----DPEILMEQ------------------- 393

  Fly   392 GQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRF--SAHDIQNGFEG 454
                                |.|       :|    ||::.||..||.: :|  ...|.::|..|
  Rat   394 --------------------GEF-------LN----YDIMLGVNQGEGL-KFVEGVVDPEDGVSG 426

  Fly   455 ERRDKIIRTYVRNAYNY-----HLNEIFYTIVNEYTDW-DRTSQHPINTRDTAVAALSDAQFVAP 513
            ...|..:..:|.|.|.|     .|.|   ||...|||| ||  .:|...|.|.||..:|.|:|.|
  Rat   427 TDFDYSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDWADR--DNPETRRKTLVALFTDHQWVEP 486

  Fly   514 IVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTV 578
            .|...|:.|           ..|||                  .|||.|.:..:....|......
  Rat   487 SVVTADLHA-----------RYGSP------------------TYFYAFYHHCQSLMKPAWSDAA 522

  Fly   579 HGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERN 643
            ||:::||:||.|:|.....||.|::|::..||..||.:|||||:||:||:...||:.. :..:.|
  Rat   523 HGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKF-IHTKAN 586

  Fly   644 RFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDD 708
            ||..:.|..|:|..|.||.||:|||:::|:||.:::.|..|:|.|:..        |::|  |..
  Rat   587 RFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNL--------HDMF--HYT 641

  Fly   709 MDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVE 773
            ....:.| .||                ::.||.:                            |..
  Rat   642 STTTKVP-PPD----------------TTHSSHI----------------------------TRR 661

  Fly   774 PNNMYTTCIPIGGNYSSSGGVFAPTTLANASSDTLASGFEAAGYAA------YSTALSVTIAIGC 832
            ||         |..:|:.....:| ..:|.::....:|.:.||...      |||.||||||:|.
  Rat   662 PN---------GKTWSTKRPAISP-AYSNENAPGSWNGDQDAGPLLVENPRDYSTELSVTIAVGA 716

  Fly   833 SLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQR 866
            |||.||||.||.:||::||.|.|  .|::...||
  Rat   717 SLLFLNVLAFAALYYRKDKRRQE--PLRQPSPQR 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	236/686 (34%)
Nlgn3	NP_599163.2	COesterase	40..624	CDD:395084	236/686 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..195		3/25 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..691		13/100 (13%)