DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and Ces3b

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_653094.2	Gene:	Ces3b / 13909	MGIID:	3644960	Length:	571	Species:	Mus musculus

Alignment Length:	697	Identity:	195/697 - (27%)
Similarity:	283/697 - (40%)	Gaps:	172/697 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGL---ILPLDSFRFLRSVEVFLGVPYATP 78
            :||: |:.|...:......|.::....|.|..||:.|.   :...|     |.|.||||:|:|..
Mouse    13 SVLV-WVTCLLLAFVTTVTGPKVIQPEVDTPLGRVRGRQVGVKDTD-----RMVNVFLGIPFAQA 71

  Fly    79 PTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAAL-EKMPKGRLEYLKRLLPFLENQ 142
            |....|||....|.||:|:|.:....|:|.|.:..:.|....| ||:         ::.|.
Mouse    72 PVGPLRFSAPLPPQPWEGVRDASINPPMCLQDVEKMINSRFGLNEKI---------KIFPI---- 123

  Fly   143 SEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILG 207
            |||||.||::||....|.:|: ||:|:|||.|....|....|||.||:||:|||||:.|||||.|
Mouse   124 SEDCLTLNIYSPTEITAGDKR-PVMVWIHGGSLLVGSSTSQDGSALAAYGDVVVVTVQYRLGIFG 187

  Fly   208 FLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMV 272
            ||:.. :.|   ...|.|.:|.:|||.|:|.||..||||||.||:.|:..|...::.|..|| :.
Mouse   188 FLSTG-DKH---MPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGMIVSSLFLSP-IS 247

  Fly   273 RGLFHRAILMSGSAYSSWALVED--PVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLY 335
            .|||||||..||..  :..::||  |...|...|..|.|.     :....::|.||.....:||
Mouse   248 AGLFHRAISQSGIV--TTIMMEDMKPWPEAQNFANSVACG-----SASPAELVQCLLQKEGKDL- 304

  Fly   336 LADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGG 400
               |:..|...|:       ::.        |....:...:..||..|.:
Mouse   305 ---IKQKNVNISY-------IVN--------DSFFPQRPEKLLADQQFPT--------------- 336

  Fly   401 GGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIW-RFSAHDIQNGFEGERRD---KII 461
                                       ...|.||...|..| ...:.:|.:..|...|:   :|.
Mouse   337 ---------------------------VPYLLGVTNHEFGWLLLKSLNILDKLEHLSREDLLEIS 374

  Fly   462 RTYVRNAYNYHLNEIFYTIVNEYTD--WDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAAN 524
            |.::  |......||..|:::||.|  .|:::     ||......|.|..|:.|.:.....|
Mouse   375 RPFL--AIMEVPPEIMPTVIDEYLDNGSDQSA-----TRYAFQELLGDISFIIPTLNFSKYL--- 429

  Fly   525 SPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDY----PQRMGTVHGEDLPY 585
                                 ..||       |..:::::|.....:    |..:...|..:..:
Mouse   430 ---------------------RDAG-------CPVFLYEFQHTPSSFAKFKPAWVKADHASENSF 466

  Fly   586 IFGAPLVDGFSH---FPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRS 647
            :||.|.:...|.   ||: .|:.|..||..:|..|:.||||||||     ...||
Mouse   467 VFGGPFLTDESSLLAFPE-ATEEEKQLSLTMMAQWSQFARTGNPN-----GKGLP---------- 515

  Fly   648 ITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIP----ELHR 690
             .|...:.|.| |||||::.|.....:..:|..|...:|    |.||
Mouse   516 -PWPQLNQLEQ-YLEIGLESRTGVKLKKGRLQFWTETLPRKIQEWHR 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	185/656 (28%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	185/658 (28%)
		Aes	75..>245	CDD:223730	77/187 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810