Protein Alignment Nlg4 and Ces1e

DIOPT Version :9

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_598421.1
• Gene: Ces1e / 13897
• MGIID: 95432
• Length: 562
• Species: Mus musculus
• Alignment Length: 708
• Identity: 192/708 - (27%)
• Similarity: 284/708 - (40%)
• Gaps: 206/708 - (29%)

  Fly    25 CAGA----STADIYKGARLGH----RIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTK 81
            |..|    |.|....||  ||    .:|.|..|::.|..:.|:.  |.:.|.||||||:|.||..
Mouse     2 CLSALILVSLAAFTAGA--GHPSSPPMVDTVQGKVLGKYISLEG--FTQPVAVFLGVPFAKPPLG 62

  Fly    82 QNRFSPTRAPAPWDGIRISDKYSPVCPQR--LPNIQNE--TAALEKMPKGRLEYLKRLLPFLENQ 142
            ..||:|.:...||..::.:..|.|:|.|.  ...|.|:  |...||:|          |.|
Mouse    63 SLRFAPPQPAEPWSSVKNATSYPPMCFQDPVTGQIVNDLLTNRKEKIP----------LQF---- 113

  Fly   143 SEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILG 207
            ||||||||:::|.:...:: :|||:|:|||........:.|||.||:::..||||.:.|||||.|
Mouse   114 SEDCLYLNIYTPADLTKSD-RLPVMVWIHGGGLVLGGASTYDGLVLSTHENVVVVVIQYRLGIWG 177

  Fly   208 FLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMV 272
            |.:....   |:| .|:|.:||:|||||:|.||.||||||.|||:.|...|...::.|:.|| :.
Mouse   178 FFSTGDE---HSR-GNWGHLDQVAALHWVQDNIAKFGGDPGSVTIFGESAGGESVSVLVLSP-LA 237

  Fly   273 RGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLA 337
            :.||.|||..||.|.::..:.::....|.|:|....|.     |.....:|.|||....|:|...
Mouse   238 KNLFQRAISESGVALTAGLVKKNTRPLAEKIAVISGCK-----NTTSAAMVHCLRQKTEEELLGT 297

  Fly   338 DIQAPNFLTS----------FGPSV-DGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGG 391
            .::...|...          |.|:| |||             |:.:......|:..|.:
Mouse   298 TLKLNLFKLDLHGDSRQSHPFVPTVLDGV-------------LLPKMPEEILAEKNFNT------ 343

  Fly   392 GQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIW------RFSAHDIQN 450
                                                ...:.|:...|..|      .:...|:
Mouse   344 ------------------------------------VPYIVGINKQEFGWILPTMMNYPPSDV-- 370

  Fly   451 GFEGERRDKIIRTYVRNAYNYHLN---EIFYTIVNEY-TDWDRTSQHPINTRDTAVAALSDAQFV 511
                 :.|::....:....::.||   :.....:.:| .|.|.|.::    :|..:..:.|..|.
Mouse   371 -----KLDQMTAMSLLKKSSFLLNLPEDAIAVAIEKYLRDKDYTGRN----KDQLLELIGDVVFG 426

  Fly   512 AP--IVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDY---------- 564
            .|  ||..|             ...||:|                  .|.|.|.|
Mouse   427 VPSVIVSRG-------------HRDAGAP------------------TYMYEFQYSPSFSSEMKP 460

  Fly   565 QTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEH 629
            .|..||        ||:::..:||||::.|      ..::.|..||:.:|.||.||||.||||
Mouse   461 DTVVGD--------HGDEIYSVFGAPILRG------GTSEEEINLSKMMMKFWANFARNGNPN-- 509

  Fly   630 HRQDSSLPVSKERNRFRSITWENYDPLHQK--YLEIGMKPRIKNHFRAHQLSIWLRLI 685
               ...||           .|..||   ||  ||:||...:.....:..:::.|..|:
Mouse   510 ---GQGLP-----------HWPEYD---QKEGYLQIGATTQQAQKLKEKEVAFWTELL 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	182/676 (27%)
Ces1e	NP_598421.1	COesterase	25..546	CDD:278561	182/677 (27%)
		Aes	44..>242	CDD:223730	89/217 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255	559..562

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810