Protein Alignment Nlg4 and Ces1c

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_031980.2
• Gene: Ces1c / 13884
• MGIID: 95420
• Length: 554
• Species: Mus musculus
• Alignment Length: 691
• Identity: 181/691 - (26%)
• Similarity: 279/691 - (40%)
• Gaps: 173/691 - (25%)

  Fly    22 WMHC---AGASTADIYKGARLGHR----IVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPP 79
            |:|.   |..:...|     |||.    :|.|..|::.|..:.|:.|.  :.|.||||||:|.||
Mouse     2 WLHALVWASLAVCPI-----LGHSLLPPVVDTTQGKVLGKYISLEGFE--QPVAVFLGVPFAKPP 59

  Fly    80 TKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSE 144
            ....||:|.:...||..::.:..|.|:|.|        .|...|:........|.:||.  ..||
Mouse    60 LGSLRFAPPQPAEPWSFVKNATSYPPMCSQ--------DAGWAKILSDMFSTEKEILPL--KISE 114

  Fly   145 DCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFL 209
            ||||||::||.:. ....:|||:|:|||........:||:|..|:::..|||||:.|||||.|..
Mouse   115 DCLYLNIYSPADL-TKSSQLPVMVWIHGGGLVIGGASPYNGLALSAHENVVVVTIQYRLGIWGLF 178

  Fly   210 NANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRG 274
            :.. :.|:   ..|:..:||:|||.|:|.||..|||:|:|||:.|..:|...::.|:.|| :.:.
Mouse   179 STG-DEHS---PGNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESSGGISVSVLVLSP-LGKD 238

  Fly   275 LFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADI 339
            ||||||..||...::....::     |:...|:..|:....:.....:|.|||.....:|.....
Mouse   239 LFHRAISESGVVINTNVGKKN-----IQAVNEIIATLSQCNDTSSAAMVQCLRQKTESELLEISG 298

  Fly   340 QAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGG 404
            :...:..|....:||||:....     ::::|..|..:
Mouse   299 KLVQYNISLSTMIDGVVLPKAP-----EEILAEKSFNT--------------------------- 331

  Fly   405 SGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGF-EGERRDKIIRTYVRNA 468
                                   ...:.|....|..|..... :||.. ||:..::.....:|.
Mouse   332 -----------------------VPYIVGFNKQEFGWIIPMM-LQNLLPEGKMNEETASLLLRR- 371

  Fly   469 YNYHLN---EIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVS 530
            ::..||   .:...::.:|.   |....|....:..:....|..|..|.|.....|
Mouse   372 FHSELNISESMIPAVIEQYL---RGVDDPAKKSELILDMFGDIFFGIPAVLLSRSL--------- 424

  Fly   531 SSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDY----------QTKDGDYPQRMGTVHGEDLPY 585
                     .:|..||           |.|.|.|          ||.:||        ||:::.:
Mouse   425 ---------RDAGVST-----------YMYEFRYRPSFVSDKRPQTVEGD--------HGDEIFF 461

  Fly   586 IFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITW 650
            :|||||:      .:..::.||.||:.||.||.||||.||||     ...||           .|
Mouse   462 VFGAPLL------KEGASEEETNLSKMVMKFWANFARNGNPN-----GEGLP-----------HW 504

  Fly   651 ENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLI----PE 687
            ..||. .:.||:||...:.....:|.:::.|..|:    ||
Mouse   505 PEYDE-QEGYLQIGATTQQAQRLKAEEVAFWTELLAKNPPE 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	170/651 (26%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	169/642 (26%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554