Protein Alignment Nlg4 and LOC1281357

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_061497244.1
• Gene: LOC1281357 / 1281357
• VectorBaseID: AGAMI1_013672
• Length: 1268
• Species: Anopheles gambiae
• Alignment Length: 1500
• Identity: 402/1500 - (26%)
• Similarity: 589/1500 - (39%)
• Gaps: 522/1500 - (34%)

  Fly     6 LLLLLRLL----LLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLR- 65
            |||.|.|.    ::||.:..    .|...|.........:.:|:|:||.|.|::     ||.:.
Mosquito    22 LLLTLWLTGSGRMVPTGVAG----TGPGPATSLNNITYSNSLVKTKYGPLRGIV-----FRTVPV 77

  Fly    66 SVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQ-NETAALEKMPKGRL 129
            .||.|||||||:||....|:.|...|:.|...|:.|:::|||||:||.:. .:...|..:|..||
Mosquito    78 VVEGFLGVPYASPPIGSLRYMPPVTPSTWKAPRLVDRFAPVCPQKLPKLDGTDAGVLGDLPIDRL 142

  Fly   130 EYLKRLLPFLENQSEDCLYLNVFSP---VNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASY 191
            :.|:||:|.|.||||||||||::.|   ..|...:...|.||:|||||:||:|||.||||.||..
Mosquito   143 KQLRRLVPTLVNQSEDCLYLNLYVPHAEDTAHRPDHLKPSIVYIHGESYEWNSGNHYDGSTLAMN 207

  Fly   192 GEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHG 256
            |.|:|||:|:|||:||||.......|.   .|:||||.:|.|||:::|:..|||||..:||.|||
Mosquito   208 GNVIVVTINFRLGVLGFLKTGAKGSAQ---GNFGLMDLVAGLHWLRENLVAFGGDPAKITLMGHG 269

  Fly   257 TGAACINYLMTSPTMVRG-LFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHE 320
            ||||..|.|..||  |.| |.||.:|:||||.|.||:..||:....|:|::.:|| .|.:|   |
Mosquito   270 TGAALANILAVSP--VAGDLIHRVVLLSGSALSPWAIQRDPLSVKRKVAQQTSCT-GDVVN---E 328

  Fly   321 QIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQS 385
            .:..|||...|.:|....:.:|.||..|.|.|||.||.|..:       ...|:.:...||...|
Mosquito   329 DLAPCLRTKSLAELMNISLSSPRFLPGFAPFVDGTVITPAKA-------AVINNLKIPTDSAIAS 386

  Fly   386 SAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQN 450
            :                  ||..|...:             ..|||||:.|.||....:|.|::.
Mosquito   387 T------------------SGIEFSNFH-------------KQDVLFGLTTYESYLELTAADLEF 420

  Fly   451 GFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIV 515
            ||...:||:|:||:|||.|.||||||:..:.||||:|:|:.:.....||..:..|||....||:|
Mosquito   421 GFNETKRDRILRTFVRNTYRYHLNEIYSALKNEYTNWERSPRSAYGYRDAVLELLSDGLTAAPLV 485

  Fly   516 RAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHG 580
            :...:           .|..|                  ||.||..|.:|:.:..:|||.|:|.|
Mosquito   486 QLSHL-----------HSLQG------------------GRSYFLHFKHQSHEWKFPQRTGSVRG 521

  Fly   581 EDLPYIFG---APLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPN--------------- 627
            ||:|:..|   :|:      ||...|:.:..:|..||.:..||.:|||||
Mosquito   522 EDVPFALGFSPSPM------FPLTLTRLDMQVSSTVMRYLCNFVKTGNPNGLRTPRMDVFVNSNN 580

  Fly   628 ---------------------EHHRQD------SSLP---------------------------- 637
                                 ...:||      :.||
Mosquito   581 KRSWNPAKKPHNETLMRQLVSSFRQQDPPPQPRNPLPGMPAQPLLTPEQALMQQQLQQYYRKEQQ 645

  Fly   638 -------VSKERNRF-------------------------------------------------- 645
                   ..::|.||
Mosquito   646 SARQPKHSRRKRTRFSNDLQRYGSSEGAAYGSSEEAGTLGGSNGNGGRGGDDEDDEEEEEEENGD 710

  Fly   646 ---------RSIT-------------------------WENYDPLHQKYLEIGMKPRIKNHFRAH 676
                     ||.|                         |.:||..:|.::|||.:...|:|:|.|
Mosquito   711 RRDGGESGGRSETEPSYYSVDSDYVYSGFTTIKYNLPFWGHYDTTNQVFMEIGSQVVPKSHYRGH 775

  Fly   677 QLSIWLRLIPELHRA-GMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSS 740
            :||:||.|||:||.: .:.::..||:.|...:.| .|:|
Mosquito   776 KLSLWLSLIPQLHSSFNIPELSMRHHHFSEENPM-FYDG-------------------------- 813

  Fly   741 RLLLVDEQL----MMKKGRGLNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGGVFAPTTLA 801
               ||.||:    :|..|...:.::.::....:.:....::.|.|.|   |.:......|...|.
Mosquito   814 ---LVREQIIEPPLMHIGFVTSTTSKMHKTETIASTILQSISTECPP---NITFIQTASASWPLH 872

  Fly   802 NA--------SSDTLASGFEAAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDK----TRL 854
            |:        |:.:|.:....:.:.:|||||::||.:||.||.||||||..:||||:|    :|:
Mosquito   873 NSALPTQHGDSNRSLINRLTNSYHRSYSTALAITIGVGCFLLFLNVLIFVAIYYQREKRESNSRM 937

  Fly   855 EVKTLQKQYQQRSLHQQVPYPPEPIKHAHYHMGHSQSSANVIVDVESHQDQAGQAAMLLQAAAAA 919
            ::..|:                            .:|..||:      :..:|..|    |||||
Mosquito   938 KINLLE----------------------------LESRLNVV------ESSSGAVA----AAAAA 964

  Fly   920 AAAAANDVK-------PPPPH--------------------ICSNTGMQQQQQVGGGSGGALNNG 957
            ||||:.:||       .||||                    ..|.|....:...|||||
Mosquito   965 AAAASGEVKEETSFSVAPPPHQEDDGPASHTKGAPLRVASSASSTTATSAKAAPGGGSG------ 1023

  Fly   958 GIEGSKVTTDNL---------GNVT----YSTSS-KQQQQHQQQQQQQQREHMQIKGMTGTQTFG 1008
               .:.:.|..|         |:.|    .|||: |...:.:.||||||::|:
Mosquito  1024 ---PNSIQTIELSLTPHYHGHGHATSMRRSSTSAIKHSHKCELQQQQQQQQHL------------ 1073

  Fly  1009 RSGSGSGGGAGGGAGSASGGASVVVSGSSVSYNPGMMTLPKSGGLHHAATLNYARNTTALNMSGG 1073
                                           |:            ||.::.:..|..:...:|
Mosquito  1074 -------------------------------YH------------HHQSSCSSNRTVSPKKVS-- 1093

  Fly  1074 GTALVDSRGNVLLTSTAVGPGMAGTGAGGGSSGGGGGGDC--------------MTLPRNLGLAA 1124
                            .|.|..:...:..||:...|....              ::||:.|
Mosquito  1094 ----------------IVSPNPSDDQSSSGSASSLGTDQAPPPVHTRDTRSYSVVSLPKEL---- 1138

  Fly  1125 AGRHNPTTELQQYQQQQQSSKHQSNGAVLTGMQSHHIRGPRPPLRTASSTTTNSSSNNSAMGVAV 1189
               .|.:|   ||...:.|.       :|.|...|  ..|||.: .:::|.|.............
Mosquito  1139 ---CNQST---QYDLAEVSH-------LLVGTGQH--PAPRPTM-ASTATMTRRRDLREDFRSTP 1187

  Fly  1190 GVGGGVGNMLLDQ-----------TPSG-GSSSSGVSSAPSSSKGHHTHSHSHAAHLVHSHGDGL 1242
            .:||...::...:           .|.| ||:::|:...||..:.||.|.|.|..|......||.
Mosquito  1188 AIGGSTRSLATAKEYTHRDGSELHVPGGSGSAATGILRPPSLHQLHHQHQHLHHLHQSQQPTDGP 1252

  Fly  1243 VLTSA 1247
            ..:|:
Mosquito  1253 ASSSS 1257

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	255/807 (32%)
LOC1281357	XP_061497244.1	None