Protein Alignment Nlg4 and LOC1274229

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_061501508.1
• Gene: LOC1274229 / 1274229
• VectorBaseID: AGAMI1_001999
• Length: 1390
• Species: Anopheles gambiae
• Alignment Length: 1532
• Identity: 389/1532 - (25%)
• Similarity: 590/1532 - (38%)
• Gaps: 477/1532 - (31%)

  Fly    42 RIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPV 106
            |.:..:.|.|.|.:..:.....|::|:.|||:|||..|....||.|..||.||:|::::.|.|||
Mosquito   131 RDIAVKQGILRGSVRVMHPQSGLKNVDQFLGIPYAEAPVGSRRFMPPSAPIPWNGLKMATKLSPV 195

  Fly   107 CPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGAN-EKKLPVIVFI 170
            |||.||::.|   |.....|||.:.:|||||:|:.:||||||||::.|...|.. :.|.||||:|
Mosquito   196 CPQNLPSLNN---ANNNYSKGRYDQIKRLLPYLKVESEDCLYLNLYVPSYDGIGPQTKYPVIVYI 257

  Fly   171 HGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHW 235
            ||||:||:||||||||:|||||:|:|||||:|||||||:....:.|.   .:|:||:||:|||.|
Mosquito   258 HGESYEWNSGNPYDGSILASYGQVIVVTLNFRLGILGFMKPGISDHT---TSNFGLLDQIAALQW 319

  Fly   236 IQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFA 300
            |::||..||||...||:.|.||||||:|:||.|| :.:|||||||||||||.|.|||.:.|:...
Mosquito   320 IKENIGAFGGDAKLVTVMGQGTGAACVNFLMVSP-VAKGLFHRAILMSGSALSDWALTQHPLQST 383

  Fly   301 IKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPG--HSN 363
            :::.:.:||    .:|..::::..|||.....::......:|.|.|.|||.|||:|| |.  |..
Mosquito   384 MQVLQGLNC----PLNGENDEVTACLRRKRYSEILGVKTASPQFSTRFGPIVDGLVI-PNMPHKV 443

  Fly   364 LDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHY 428
            :                                      |.....|.|                |
Mosquito   444 M--------------------------------------GQYSDIFSG----------------Y 454

  Fly   429 DVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTD--WDRTS 491
            |:|:|:...||....:|..:..|.....||.::|.|::|.:....:......:.||||  .|...
Mosquito   455 DLLYGMTELESYHILNAVALTYGLLENERDNLLRFYMQNRFEIRPDLALAATLREYTDIYMDPNK 519

  Fly   492 QHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGR 556
            ......||..:..||||:..||:|:.|..|:..:|                             :
Mosquito   520 ALADEHRDNLLEILSDARVAAPMVQTGLYLSKVNP-----------------------------K 555

  Fly   557 CYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPL--VDGFSHFPQNYTKSETALSEAVMIFWTN 619
            ||.|||.:.::.|:|.:...:|.||||.|:|||||  |..|.|   :|...|...|||||.:::|
Mosquito   556 CYMYVFGHNSEAGEYGRLSQSVVGEDLAYVFGAPLGQVGPFQH---HYNARERLFSEAVMKYFSN 617

  Fly   620 FARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRL 684
            ||:||||....: |..|.::.|...:..:.|..|:.::|.||.:|:.|.:.:.:|...:..|...
Mosquito   618 FAKTGNPKAPWK-DLFLNLNPEDWSYYDVDWPEYNSINQSYLHMGITPVVGHRYRQKYMKFWNEE 681

  Fly   685 IP-ELHRAGMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQ 748
            :| ||.:.......|.::        |.:..|            ||.|
Mosquito   682 LPEELKKITSSKAYAPYS--------DFFSPP------------GAGG----------------- 709

  Fly   749 LMMKKGRGLNGSAYLNGILGVTTVEPN------NMYTTCI-------------------PIGGNY 788
               |:|.|:  ||.:..:.|.||..|:      |:|...:                   |:.|
Mosquito   710 ---KQGGGV--SAVVGRMRGGTTPHPDYPTGHINLYPIHVDIERPTEDPFRELLYQMKDPLAG-- 767

  Fly   789 SSSGGVFAPTTLA-------NASSDTLASGF-------------------------EAAGYAA-- 819
              .|...||.|.:       .||...||:|.                         |..|.|.
Mosquito   768 --PGMYNAPATSSAAAIPEKGASPAQLAAGVLEHPKHPKQLQQSGKDGPFGVTDEQELDGGATEI 830

  Fly   820 --YSTALSVTIAIGCSLLILNVLIFAGVYYQR-------------------------DKTRLE-- 855
              ..:.|::.||:....|:.|:::..|...:|                         |.|.||
Mosquito   831 MKSESTLTILIAVAIVFLLFNIVVIVGYLVRRHLGRPGVGGVGVGGVAGGRKVKRKYDDTMLESA 895

  Fly   856 -------VKTLQKQYQQRSLHQQVPYPPEPIKHAHYHMGHSQSSANVIVDVESHQDQAGQAAMLL 913
                   |...:|:.....||..         |.|:|:.|                    .|.||
Mosquito   896 AAVVVAGVGLGEKEDGCNQLHGH---------HHHHHLPH--------------------GAYLL 931

  Fly   914 QAAAAAAAAAANDVKPPPPHICSNTGMQQQQQVGGGSGGALNNG--GIEGSKVTTD----NLG-- 970
            ..||......:|..:|           ..:|..||...|.::.|  .::......|    :.|
Mosquito   932 DEAATMMLRKSNSYEP-----------VAKQPFGGELHGPVSIGVDAVDAHTKVCDWMVASAGCR 985

  Fly   971 --------NVTYSTSSKQQQQHQQQQQQQQREHMQIK------------GMTGTQTFGRSGSGSG 1015
                    .::.:..:..|.:.....:|:..|..:.|            .::|....||.|.|..
Mosquito   986 MAPAVPPHKISVAIDATPQARGNSVLRQEPIEITKAKSFEYGATDEVDCAVSGCPGEGRMGEGDA 1050

  Fly  1016 GGAGGGAGSASGGASVVVSGSSVSYNPGMMTLPKSG-GLHHAATLNYARNTTALNMSGGG---TA 1076
            .|.|..:...|...|     ||.:.:....|:|.:| ||::... :|..........||.   |:
Mosquito  1051 SGTGSSSSGTSSSCS-----SSATTDELKQTMPGAGAGLYYNCP-DYPVRRFGATGEGGEEEVTS 1109

  Fly  1077 LVDS---RGNVLLTS------------------------TAVGPGMAGTGAGGGSSGGGGG---- 1110
            .::.   .|::.:||                        ..|.|....||..||.:..|..
Mosquito  1110 FIEQDTPAGDINVTSRDKSTEKDPLSPEEALRVIQRRNFPKVLPDHPRTGGTGGPTTVGTSMKRR 1174

  Fly  1111 -------------GDCMTLPRNLGLAAAGRHNPTTELQ---------QYQQQQQSSKHQSNGAVL 1153
                         |:|.:|.|.  .|.|||..|....:         ..:|.:.|:...|:..::
Mosquito  1175 SLPPQSLYGALPHGNCHSLRRE--AAGAGRLIPAPPPRICSTLGRPAAVRQARASNNFISSPPIV 1237

  Fly  1154 T-----------GMQSHHIRGPRPPLRTASSTTTNSSSNNSAMGVAVGVGGGVGNMLLDQTPSGG 1207
            .           .:.:.|: ||..|....|:..|.|..|  ::|.....|....:   |..||..
Mosquito  1238 AEEPPVEEEPPIALNTLHV-GPLLPTHQESTYMTMSRQN--SLGSECEPGSSEAD---DDRPSEE 1296

  Fly  1208 SSSSGVSSAPSSSKGHHTHSHSHAAHLVHSHGDGLVLTSASPVGGQQQQHPQQHQHPQQQQQVPQ 1272
            .....:.......:.|:::                    ..|||  ..:.|...:.|   :.|.:
Mosquito  1297 QPPVDIICIEHKPENHYSY--------------------VRPVG--LMRTPSSFKCP---EAVSR 1336

  Fly  1273 AAMDEMREFYAPKQPDDDGQLNGTPVDADAATQVVGAGRTGGMGAPPISASDHKQRQLKKLRFKR 1337
            ....|.|..       .||: .|.|...|||||                       .|:.:|
Mosquito  1337 TEGGEARSV-------GDGE-TGQPAPIDAATQ-----------------------SLQLVR--- 1367

  Fly  1338 EIHALALEGGDVARGYCSCDEQWTNSSSPTSTTTSAT 1374
                                :::::.||.|.||:.:|
Mosquito  1368 --------------------DKFSSDSSATDTTSGST 1384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	235/644 (36%)
LOC1274229	XP_061501508.1	None