Protein Alignment Nlg4 and LOC1270335

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_309020.4
• Gene: LOC1270335 / 1270335
• VectorBaseID: AGAMI1_002073
• Length: 1818
• Species: Anopheles gambiae
• Alignment Length: 1119
• Identity: 259/1119 - (23%)
• Similarity: 380/1119 - (33%)
• Gaps: 388/1119 - (34%)

  Fly    56 LPL-DSFRFLRSVE-------------------------VFLGVPYATPPTKQNRFSPTRAPAPW 94
            :|| .|.|::|:::                         .|.|:|||.||..:.||   |||.|.
Mosquito    18 VPLASSVRWMRNIDRVNVKVHQGTVSGVKEQLPNGGVFCAFRGIPYAKPPVGELRF---RAPQPL 79

  Fly    95 DGIRISDKYSPVCPQRLP------NIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFS 153
            |              |.|      :::.:......|....||           .|||||:|||::
Mosquito    80 D--------------RFPYPVLDCSVERDVCFSRNMFTQELE-----------GSEDCLHLNVYT 119

  Fly   154 PVNAGANEK---KLPVIVFIHGESFEWSSGNP--YDGSVLASYGEVVVVTLNYRLGILGFLNANP 213
            |   ||.|:   .|||:|||||.:|.:.|||.  |....|.. .||:|||||||||.||||:. |
Mosquito   120 P---GAGERAGQPLPVMVFIHGGAFLFGSGNGDCYSPEYLLQ-DEVIVVTLNYRLGALGFLHL-P 179

  Fly   214 NPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHR 278
            :....   .|.||.||:|.|.|:||||..|.|||::|||.|...|||.::..|.| .:.|..|||
Mosquito   180 SQGIE---GNAGLKDQLAVLRWVQQNIAAFNGDPHNVTLFGESAGAASVHLHMLS-LVSRQYFHR 240

  Fly   279 AILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCL---RDVPLEDLYL---- 336
            ||..||::...|.:..|.:.....||:.::   ||  .:..||:...|   ....|..|.|
Mosquito   241 AICQSGASVMEWVMQRDSINRTRSLARHID---PD--AKTDEQVYQTLLAADKAQLMGLMLHTLS 300

  Fly   337 ADIQAPNFLTSFGPSVDGVVIRPGHSNLD----IDDLMARNSRRSSADSGFQSSAGGGGGQGGGA 397
            ||.:.......|.|     |:..|....|    :...:|...|
Mosquito   301 ADEKRRGLPMPFKP-----VVEEGEPGPDTVVPVHPFVAMQQR---------------------- 338

  Fly   398 GGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGE--RRDKI 460
                               ...|||      .::||               .|..||.  ..|.|
Mosquito   339 -------------------DRTGTM------PIIFG---------------NNDREGTIMMMDAI 363

  Fly   461 IRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPIN-----------TRDTA---VAALSDAQFV 511
            .:.   :.|:..:..:....||...|.....|....           |::||   ...::|..|
Mosquito   364 KKL---DLYDNDMARMIPRTVNMAPDSAACEQLASEVKQFYCGAQGVTKETANQLADLMTDYHF- 424

  Fly   512 APIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRM- 575
                   .||                  ||..|...| ..||:...::|.|.|..:...|.:.:
Mosquito   425 -------GIL------------------ANTCAELHA-RYQPNSPMFYYQFSYDGELNMYKKLLQ 463

  Fly   576 ----GTVHGEDLPYIFGAPLVDGFSHFPQNY-TKSET---ALSEAVMIFWTNFARTGNPNEHHRQ 632
                |..|.::|.|:|...|.        || .|.:|   .:.:.:...|||||:.|:|..  ..
Mosquito   464 LSIPGACHADELSYLFLMRLA--------NYDVKPDTEAGRVRQLMCRLWTNFAKHGHPTP--AN 518

  Fly   633 DSSLPVSKERNRFRSITWENYDPL---------HQKYLEIGMKPRIKNHFRAHQLSIWLRLIPEL 688
            |.|||       ||   |:..|.:         ..:.|:|..:|::.......::..|..:....
Mosquito   519 DESLP-------FR---WQPVDKIAPSAASESFRLQCLDIAAEPKMIMDPAKERIDFWRTVYKRW 573

  Fly   689 H--------------------RAGMEDVIA--------------RHNLFRNHDDMDLYEGPVKPD 719
            :                    |||...:||              |.|:..:...|..:...|...
Mosquito   574 NDDFLKVNMSGIGFANVFSAARAGCSVMIASTAPTRSITGVKGNRTNIVWSRSLMHWFCSAVICS 638

  Fly   720 PFG-ISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVT------TVEPNNM 777
            ... ||.|..||..|.||..|||..|        :.|......::|.:...:      |..|...
Mosquito   639 ALAPISVARTASSVSDSSPPSSRASL--------RARSAGSRCHINQMAEASSCTVNITSGPIRG 695

  Fly   778 YTTCIPIGGN--YSSSGGVFA-----------PTTLANASSDTLASGFEAAGYAAYSTALSVTIA 829
            ..|.:|.|..  |:..|..:|           |..|.:.|.|         |.||........::
Mosquito   696 TVTPLPDGSGPCYTFKGIPYAVPPVGPLRFQPPQPLTHHSDD---------GQAALDCTRERAVS 751

  Fly   830 IGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQRSLHQQVPYPPEPIKHAHYHMGHSQSSAN 894
            :..|.|..|..:.:     .|...|.|.|              |..|.|:          ..|::
Mosquito   752 LASSYLPPNPPLAS-----EDCLYLNVYT--------------PKNPTPL----------DGSSD 787

  Fly   895 VIVDVESHQDQ----AGQAAML----LQAAAAAAAAAANDVKPPPPHIC-------SNTGMQQQQ 944
            :.|.|..|...    :|.:::.    |.|...|.....|....|...:|       .|.|::.|:
Mosquito   788 LPVMVWLHGGAFCTGSGDSSIYHPEWLVAMGPACVVTVNYRLGPAGFLCLPSAGIYGNMGLKDQR 852

  Fly   945 --------QVGGGSGGALN-------NGGI--------EGS-----KVTTDNLGNVTYSTSSKQQ 981
                    .:|...|.|.|       .||:        |||     |:...:    ..:|:|...
Mosquito   853 LALQWVRANIGRFGGDAHNVTLFGESAGGVSAHLHYLSEGSYQLFHKLICQS----GVATTSITF 913

  Fly   982 QQHQQQQQQQQREH 995
            |:|.:|:.::..|:
Mosquito   914 QKHPEQKARRLAEY 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	180/706 (25%)
LOC1270335	XP_309020.4	None