DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and Ces1g

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_067431.2	Gene:	Ces1g / 12623	MGIID:	88378	Length:	565	Species:	Mus musculus

Alignment Length:	709	Identity:	194/709 - (27%)
Similarity:	278/709 - (39%)	Gaps:	208/709 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 WMHCAGASTADIYKGARLGH----RIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQ 82
            |: || .|...:.....|||    .:|.|.:|::.|..:.|:.|.  :.|.||||||:|.||...
Mouse     2 WL-CA-LSLISLTACLSLGHPSLPPVVHTVHGKVLGKYVTLEGFS--QPVAVFLGVPFAKPPLGS 62

  Fly    83 NRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQ----- 142
            .||:|.....||..::.:..|.|:|      .||..|||            ||.....||
Mouse    63 LRFAPPEPAEPWSFVKHTTSYPPLC------YQNPEAAL------------RLAELFTNQRKIIP 109

  Fly   143 ---SEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLG 204
               ||||||||:::|.:...| .:|||:|:|||........:.|||..||.:..||||.:.||||
Mouse   110 HKFSEDCLYLNIYTPADLTQN-SRLPVMVWIHGGGLVIDGASTYDGVPLAVHENVVVVVIQYRLG 173

  Fly   205 ILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSP 269
            |.||.:....   |:| .|:|.:||:|||||:|.||..|||:|.|||:.|...|...::.|:.||
Mouse   174 IWGFFSTEDE---HSR-GNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGESVSVLVLSP 234

  Fly   270 TMVRGLFHRAILMSGSAYSSWALVEDPVLF-------AIKLAKEVNCTIPDDINRHHEQIVDCLR 327
             :.:.||||||..|       :::.:|.||       |.|:|....|.....     ..:|.|||
Mouse   235 -LAKNLFHRAIAQS-------SVIFNPCLFGRAARPLAKKIAALAGCKTTTS-----AAMVHCLR 286

  Fly   328 DVPLEDL-------------YLADIQAPNFLTSFGPSV-DGVVIRPGHSNLDIDDLMARNSRRSS 378
            ....::|             :|.|   |.....|.|:| |||             |:.:......
Mouse   287 QKTEDELLEVSLKMKFGTVDFLGD---PRESYPFLPTVIDGV-------------LLPKAPEEIL 335

  Fly   379 ADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIW-- 441
            |:..|.:                                          ...:.|:...|..|
Mouse   336 AEKSFNT------------------------------------------VPYMVGINKHEFGWII 358

  Fly   442 -RFSAHDIQNGFEGERR--DKIIRTYVRNAYNYHLN---EIFYTIVNEYTDWDRTSQHPINTRDT 500
             .|....:     .||:  .|...:.:..||.. ||   ::....:.:|..   .::.|....|.
Mouse   359 PMFLDFPL-----SERKLDQKTAASILWQAYPI-LNISEKLIPAAIEKYLG---GTEDPATMTDL 414

  Fly   501 AVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQ 565
            .:..:.|..|..|.|...           .|...||:|                  .|.|.:.|:
Mouse   415 FLDLIGDIMFGVPSVIVS-----------RSHRDAGAP------------------TYMYEYQYR 450

  Fly   566 TK--DGDYPQRMGTVHGEDLPYIFGAP-LVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPN 627
            ..  ..|.||.:...|.::|..::||| |.:|.|       :.|..||:.||.||.||||.||||
Mouse   451 PSFVSDDRPQELLGDHADELFSVWGAPFLKEGAS-------EEEINLSKMVMKFWANFARNGNPN 508

  Fly   628 EHHRQDSSLPVSKERNRFRSITWENYDPLHQK--YLEIGMKPRIKNHFRAHQLSIWLRL 684
                 ...||           .|..||   ||  ||:||:..:..:..:..::..|..|
Mouse   509 -----GEGLP-----------HWPEYD---QKEGYLQIGVPAQAAHRLKDKEVDFWTEL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	185/679 (27%)
Ces1g	NP_067431.2	COesterase	24..545	CDD:278561	185/680 (27%)
Ces1g	NP_067431.2	Aes	<121..>239	CDD:223730	51/123 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810