Protein Alignment Nlg4 and Nlgn2

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_446444.1
• Gene: Nlgn2 / 117096
• RGDID: 621118
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 844
• Identity: 270/844 - (31%)
• Similarity: 385/844 - (45%)
• Gaps: 206/844 - (24%)

  Fly    43 IVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVC 107
            :|.|.|||:.|:...|:: ..|..|..||||||||||....||.|..|||.|.|:|.:....|.|
  Rat    43 VVNTAYGRVRGVRRELNN-EILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPAC 106

  Fly   108 PQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEK---------- 162
            ||   |:.....|: .:|....:.|:....:::||||||||||::.|...|...|
  Rat   107 PQ---NLHGALPAI-MLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPP 167

  Fly   163 --------KLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHA 219
                    |.||::|:||.|:...:||.:||||||:||.|:|.|||||||:||||:...    .|
  Rat   168 DTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGD----QA 228

  Fly   220 RVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSG 284
            ...||||:||:.||.|:.:||..|||||..:|:.|.|.||:|:|.|:.|... .|||.:||..||
  Rat   229 AKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHS-EGLFQKAIAQSG 292

  Fly   285 SAYSSWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFG 349
            :|.|||::...|:.:...||.:|.|...|.     .:.|:|||.....:|...|:|...:..:||
  Rat   293 TAISSWSVNYQPLKYTRLLAAKVGCDREDS-----TEAVECLRRKSSRELVDQDVQPARYHIAFG 352

  Fly   350 PSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYF 414
            |.|||.|:..     |.:.||.:                                       |.|
  Rat   353 PVVDGDVVPD-----DPEILMQQ---------------------------------------GEF 373

  Fly   415 GGSGAGTMNMGGHYDVLFGVVTGESIWRF--SAHDIQNGFEGERRDKIIRTYVRNAYNYH----- 472
                   :|    ||:|.||..||.: :|  .:.:.::|......|..:..:|.|.|.|.
  Rat   374 -------LN----YDMLIGVNQGEGL-KFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDV 426

  Fly   473 LNEIFYTIVNEYTDW-DRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAG 536
            |.|   ||...|||| ||.:..  ..|.|.:|..:|.|:|||.|
  Rat   427 LRE---TIKFMYTDWADRDNGE--MRRKTLLALFTDHQWVAPAV--------------------- 465

  Fly   537 SPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQN 601
                 |.|...|....|   .|||.|.:..:....|:.....||::|||:||.|:|.....||.|
  Rat   466 -----ATAKLHADYQSP---VYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCN 522

  Fly   602 YTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMK 666
            ::|::..||..||.:|||||:||:||:...||:.. :..:.|||..:.|..::...::||.||:|
  Rat   523 FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKF-IHTKPNRFEEVVWSKFNSKEKQYLHIGLK 586

  Fly   667 PRIKNHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDLYE---GPVKPDPFGISTAAG 728
            ||:::::||::::.||.|:|.||....|       ||.....:..|.   .|..|.|       |
  Rat   587 PRVRDNYRANKVAFWLELVPHLHNLHTE-------LFTTTTRLPPYATRWPPRTPGP-------G 637

  Fly   729 ASGSSSSSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGG 793
            .||:......:                               |:.|.    :.|.:|
  Rat   638 TSGTRRPPPPA-------------------------------TLPPE----SDIDLG-------- 659

  Fly   794 VFAPTTLANASSDTLASGFEAAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVK 857
               |........|:          ..|||.||||:|:|.|||.||:|.||.:||:||: |.|::
  Rat   660 ---PRAYDRFPGDS----------RDYSTELSVTVAVGASLLFLNILAFAALYYKRDR-RQELR 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	225/663 (34%)
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	225/663 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661		11/90 (12%)
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	679..699		12/19 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836