Protein Alignment Nlg4 and Nlgn1

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_038957495.1
• Gene: Nlgn1 / 116647
• RGDID: 621117
• Length: 863
• Species: Rattus norvegicus
• Alignment Length: 998
• Identity: 295/998 - (29%)
• Similarity: 434/998 - (43%)
• Gaps: 290/998 - (29%)

  Fly    43 IVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVC 107
            :|.|.:|::.|:...|:: ..|..|..|||||||.|||.::||.|...|:||..||.:.:::|||
  Rat    54 LVTTNFGKIRGIKKELNN-EILGPVIQFLGVPYAAPPTGEHRFQPPEPPSPWSDIRNATQFAPVC 117

  Fly   108 PQ-----RLPNIQNETAALEKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPV------------ 155
            ||     |||.:.        :|......|..:..::::|||||||||::.|.
  Rat   118 PQNIIDGRLPEVM--------LPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDVKRISKECAR 174

  Fly   156 -------------------NAGANEK-----------KLPVIVFIHGESFEWSSGNPYDGSVLAS 190
                               :.|.|::           ..||:|:|||.|:...:||.||||||||
  Rat   175 KPGKKICRKGGPLTKTQTDDLGDNDRAEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLAS 239

  Fly   191 YGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGH 255
            ||.|:|:|:|||||:||||:...    .|...||||:|.:.||.|..:||..|||||..:|:.|.
  Rat   240 YGNVIVITVNYRLGVLGFLSTGD----QAAKGNYGLLDLIQALRWTSENIGFFGGDPLRITVFGS 300

  Fly   256 GTGAACINYLMTS--------PTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIP 312
            |.|.:|:|.|..|        ....:|||.|||..||:|.||||:...|..:|..||.:|.|.:.
  Rat   301 GAGGSCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTALSSWAVSFQPAKYARILATKVGCNVS 365

  Fly   313 DDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDD---LMARNS 374
            |.:     ::|:||:..|.::|...|:|...:..:|||.:||.||.        ||   ||.:
  Rat   366 DTV-----ELVECLQKKPYKELVDQDVQPARYHIAFGPVIDGDVIP--------DDPQILMEQ-- 415

  Fly   375 RRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGES 439
                                                 |.|       :|    ||::.||..||.
  Rat   416 -------------------------------------GEF-------LN----YDIMLGVNQGEG 432

  Fly   440 IWRFSAH--DIQNGFEGERRDKIIRTYVRNAYNYH-----LNEIFYTIVNEYTDW-DRTSQHPIN 496
            : :|..:  |..:|......|..:..:|.|.|.|.     |.|   ||...|||| ||  .:|..
  Rat   433 L-KFVENIVDSDDGVSASDFDFAVSNFVDNLYGYPEGKDVLRE---TIKFMYTDWADR--HNPET 491

  Fly   497 TRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYV 561
            .|.|.:|..:|.|:|||.|...|:           .|..|||                  .|||.
  Rat   492 RRKTLLALFTDHQWVAPAVATADL-----------HSNFGSP------------------TYFYA 527

  Fly   562 FDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNP 626
            |.:..:....|......||:::||:.|.|::.....||.|::|::..||..||.:|||||:||:|
  Rat   528 FYHHCQTDQVPAWADAAHGDEVPYVLGIPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDP 592

  Fly   627 NEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRA 691
            |:...||:.. :..:.|||..:.|..|....|.||.||:|||:|.|:||:::::||.|:|.||
  Rat   593 NQPVPQDTKF-IHTKPNRFEEVAWTRYSQKDQLYLHIGLKPRVKEHYRANKVNLWLELVPHLH-- 654

  Fly   692 GMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGRG 756
                         |.:|:..|                       :|:::::...|
  Rat   655 -------------NLNDISQY-----------------------TSTTTKVPSTD---------- 673

  Fly   757 LNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGGVFAPTTLA--NASSD---TLASGFEAAG 816
                         .|:.|....:|                |.|.|  .|..|   ...|.| :..
  Rat   674 -------------ITLRPTRKNST----------------PVTSAFPTAKQDDPKQQPSPF-SVD 708

  Fly   817 YAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQRSLHQQVPYPPE---- 877
            ...|||.||||||:|.|||.||:|.||.:||::||.|.:|.  ::...||:....:.:.||
  Rat   709 QRDYSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHDVH--RRCSPQRTTTNDLTHAPEEEIM 771

  Fly   878 PIKHAHYHMGHSQSSANVIVDVESHQDQAGQAAMLLQAA-----AAAAAAAANDVKPPPPH---I 934
            .::..|..:.|...|      :..|:       ::|:.|     ..|...:.:||....|:   :
  Rat   772 SLQMKHTDLDHECES------IHPHE-------VVLRTACPPDYTLAMRRSPDDVPLMTPNTITM 823

  Fly   935 CSNT--GMQQQQQVGGGSGGALN 955
            ..||  |:|........:||..|
  Rat   824 IPNTIPGIQPLHTFNTFTGGQNN 846

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	229/703 (33%)
Nlgn1	XP_038957495.1	COesterase	52..646	CDD:395084	229/703 (33%)