Protein Alignment Nlg4 and Ache

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_036020624.1
• Gene: Ache / 11423
• MGIID: 87876
• Length: 616
• Species: Mus musculus
• Alignment Length: 710
• Identity: 203/710 - (28%)
• Similarity: 287/710 - (40%)
• Gaps: 184/710 - (25%)

  Fly     6 LLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVF 70
            |.|||.||            .|.:.|:..:..:|   :|:.|.|:|.|:.|....    ..|..|
Mouse    18 LFLLLSLL------------GGGARAEGREDPQL---LVRVRGGQLRGIRLKAPG----GPVSAF 63

  Fly    71 LGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRL 135
            ||:|:|.||....||.|.....||.|:..:..:..||.|                     |:..|
Mouse    64 LGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQ---------------------YVDTL 107

  Fly   136 LPFLENQ---------SEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSG----NPYDGSV 187
            .|..|..         |||||||||::|....|:  ..||:::|:|..|  .||    :.|||..
Mouse   108 YPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPAS--PTPVLIWIYGGGF--YSGAASLDVYDGRF 168

  Fly   188 LASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTL 252
            ||.....|:|::|||:|..|||..   |.:.....|.||:||..||.|:|:||..|||||.||||
Mouse   169 LAQVEGAVLVSMNYRVGTFGFLAL---PGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTL 230

  Fly   253 AGHGTGAACIN-YLMTSPTMVRGLFHRAILMSGSAYSSWALVE--DPVLFAIKLAKEVNCTIPDD 314
            .|...|||.:. ::::.|:  |.|||||:|.||:....||.|.  :....|..||:.|.|. |..
Mouse   231 FGESAGAASVGMHILSLPS--RSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCP-PGG 292

  Fly   315 INRHHEQIVDCLRDVPLEDL----YLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSR 375
            ...:..:::.|||..|.:||    :....|...|..||.|.||
Mouse   293 AGGNDTELIACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVD---------------------- 335

  Fly   376 RSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYD--VLFGVVTGE 438
                                               |.:...:....:|.|...|  ||.|||..|
Mouse   336 -----------------------------------GDFLSDTPEALINTGDFQDLQVLVGVVKDE 365

  Fly   439 SIWRFSAHDIQNGFEGERRDKIIRTY----VRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRD 499
            ..: |..:.:. ||..:....|.|..    ||.......:.....:|..|||| ...:.|.:.||
Mouse   366 GSY-FLVYGVP-GFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDW-LHPEDPTHLRD 427

  Fly   500 TAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDY 564
            ...|.:.|...|.|:.:....|||.              ||               |.|.|:|::
Mouse   428 AMSAVVGDHNVVCPVAQLAGRLAAQ--------------GA---------------RVYAYIFEH 463

  Fly   565 QTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEH 629
            :.....:|..||..||.::.:|||.||....     |||..|...::.:|.:||||||||:||:
Mouse   464 RASTLTWPLWMGVPHGYEIEFIFGLPLDPSL-----NYTTEERIFAQRLMKYWTNFARTGDPND- 522

  Fly   630 HRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKP-RIKNHFRAHQLSIWLRLIPEL 688
             .:||..|           .|..|....|:|:.:.:|| .::...||...:.|.|.:|:|
Mouse   523 -PRDSKSP-----------QWPPYTTAAQQYVSLNLKPLEVRRGLRAQTCAFWNRFLPKL 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	190/664 (29%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	191/670 (29%)