DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and Ces1d

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_579829.3	Gene:	Ces1d / 113902	RGDID:	70896	Length:	565	Species:	Rattus norvegicus

Alignment Length:	701	Identity:	198/701 - (28%)
Similarity:	285/701 - (40%)	Gaps:	185/701 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATP 78
            |.|.|   |:..| |.||..|..:   ..:|.|..|::.|..:.|:.  |.:.|.||||:|:|.|
  Rat     3 LYPLV---WLFLA-ACTAWGYPSS---PPVVNTVKGKVLGKYVNLEG--FAQPVAVFLGIPFAKP 58

  Fly    79 PTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPFLENQS 143
            |....||:|.:...||:.::.:..|.|:|.|.....|    .|.::...|.|.:.  |.|    |
  Rat    59 PLGSLRFAPPQPAEPWNFVKNTTSYPPMCSQDAVGGQ----VLSELFTNRKENIP--LQF----S 113

  Fly   144 EDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGF 208
            ||||||||::|.:...| .:|||:|:|||........:.|||.||:::..|||||:.|||||.||
  Rat   114 EDCLYLNVYTPADLTKN-SRLPVMVWIHGGGLVVGGASTYDGQVLSAHENVVVVTIQYRLGIWGF 177

  Fly   209 LNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVR 273
            .:....   |:: .|:|.:||:|||||:|.||..|||:|.|||:.|...|...::.|:.|| :.:
  Rat   178 FSTGDE---HSQ-GNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGFSVSALVLSP-LAK 237

  Fly   274 GLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNC-TIPDDINRHHEQIVDCLR----DVPLE- 332
            .||||||..||...:|..:..|....|..:|....| |....:      :|.|||    |..||
  Rat   238 NLFHRAISESGVVLTSALITTDSKPIANLIATLSGCKTTTSAV------MVHCLRQKTEDELLET 296

  Fly   333 ----DLYLADIQA-PNFLTSFGPSV-DGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGG 391
                :|:..|:.. |.....|.|:| ||||             :.:.......:..|.:..
  Rat   297 SLKLNLFKLDLLGNPKESYPFLPTVIDGVV-------------LPKTPEEILTEKSFNTVP---- 344

  Fly   392 GQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGER 456
                                 |.  .|......|.....|.|....               ||:.
  Rat   345 ---------------------YI--VGINKQEFGWIIPTLMGYPLS---------------EGKL 371

  Fly   457 RDKIIRTYVRNAY-NYHLNEIFYTIVNEY----TDWDRTSQHPINTRDTAVAALSDAQFVAPIVR 516
            ..|..::.:..:| ...::|....:|.|.    ||      .|...:|.....::|..|..|.|.
  Rat   372 DQKTAKSLLWKSYPTLKISEKMIPVVAEKYFGGTD------DPAKRKDLFQDLVADVMFGVPSVM 430

  Fly   517 AGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDY----------QTKDGDY 571
            ..           .|...||:|                  .:.|.|:|          :|..||
  Rat   431 VS-----------RSHRDAGAP------------------TFMYEFEYRPSFVSAMRPKTVIGD- 465

  Fly   572 PQRMGTVHGEDLPYIFGAP-LVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSS 635
                   ||::|..:||:| |.||.|       :.||.||:.||.:|.||||.|:||     ...
  Rat   466 -------HGDELFSVFGSPFLKDGAS-------EEETNLSKMVMKYWANFARNGSPN-----GGG 511

  Fly   636 LPVSKERNRFRSITWENYDPLHQK--YLEIGMKPRIKNHFRAHQLSIWLRL 684
            ||           .|..||   ||  ||:||...:.....:..:::.|..|
  Rat   512 LP-----------HWPEYD---QKEGYLKIGASTQAAQRLKDKEVAFWSEL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	187/667 (28%)
Ces1d	NP_579829.3	COesterase	24..545	CDD:278561	187/668 (28%)
		Aes	<121..>239	CDD:223730	52/123 (42%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910